Immunology [[electronic resource] ] : mucosal and body surface defences / / Andy Williams

• Autore: Williams Andrew <1975->
• Pubblicazione: Chichester, West Sussex ; ; Hoboken, NJ, : John Wiley & Sons, c2012
• Edizione: 2nd ed.
• Descrizione fisica: 1 online resource (400 p.)
• Disciplina: 616.07/9; 616.79
• Soggetto topico: Immunology; Immune system
• Altri autori: HussellTracy LloydClare (Clare M.)
• Note generali: Includes index.
• Nota di contenuto: Immunology; Contents; Preface; List of Standard Cells and Symbols; 1 Basic Concepts in Immunology; 1.1 The immune system; 1.2 Tissues and cells of the immune system; 1.3 Activation, regulation and functions of immune responses; 1.4 Innate versus adaptive immunity; 1.5 Primary and secondary immune responses; 1.6 Immune cell development; 1.7 Mast cells and basophils; 1.8 Eosinophils; 1.9 Neutrophils; 1.10 Monocytes and macrophages; 1.11 Dendritic cells; 1.12 Natural killer cells; 1.13 CD4+ T helper cells; 1.14 CD8+ cytotoxic T cells; 1.15 B cells; 1.16 gd T cells; 1.17 Natural killer T cells ; 1.18 Anatomy of the immune system1.19 Lymph nodes; 1.20 Spleen; 1.21 Summary; 2 The Innate Immune System; 2.1 Introduction to the innate immune system; 2.2 Innate immune receptors and cells; 2.3 TLRs and pattern recognition; 2.4 TLR signalling in response to LPS; 2.5 Peptidoglycan and Nods; 2.6 Nod-like receptors recognize PAMPs and DAMPs; 2.7 Damage associated molecular patterns (DAMPs); 2.8 Complement proteins perform several innate immune functions; 2.9 The classical complement pathway; 2.10 The lectin and alternative complement pathways ; 2.11 Biological properties of complement cleavage products2.12 Opsonization by complement proteins; 2.13 Phagocytosis; 2.14 Fc receptors induce phagocytosis; 2.15 Neutrophil function and the respiratory burst; 2.16 ADCC; 2.17 NK cells recognize missing self; 2.18 Activating adaptive immunity; 2.19 Dendritic cells link innate and adaptive immunity; 2.20 Summary; 3 The Adaptive Immune System; 3.1 Introduction to adaptive immunity; 3.2 T cells and B cells recognize foreign antigens; 3.3 Overview of antibody structure; 3.4 Constant region and antibody isotypes; 3.5 B cell receptor (BCR) diversity ; 3.6 Genetic recombination of BCR genes3.7 Mechanism of VDJ recombination; 3.8 Introducing junctional diversity; 3.9 Somatic hypermutation and affinity maturation; 3.10 Immunoglobulin class switching; 3.11 Structure of Fc receptors; 3.12 Fc receptor specificity and affinity; 3.13 Cross-linking of antibody is necessary for Fc receptor signalling; 3.14 Fc receptor immune functions; 3.15 T cell receptor diversification; 3.16 T cells undergo positive and negative selection within the thymus; 3.17 Antigen presentation to T cells; 3.18 MHC class II processing pathway ; 3.19 MHC class I processing pathway3.20 Activation requires co-stimulation; 3.21 Late co-stimulatory signals; 3.22 Activation of B cell responses; 3.23 CD4+ T helper cell differentiation; 3.24 Activation of CTLs; 3.25 Generation of memory T cells; 3.26 Summary; 4 Cytokines; 4.1 Introduction to cytokines; 4.2 Structure of cytokine families; 4.3 IL-1 superfamily; 4.4 IL-6 family; 4.5 IL-10 family; 4.6 Common g-chain family; 4.7 IL-12 family; 4.8 Interferons; 4.9 TNF ligand superfamily; 4.10 Growth factors; 4.11 Functional classification Th1 versus Th2 ; 4.12 Th17, immunopathology and regulatory cytokines
• Sommario/riassunto: 2012 PROSE Award, Clinical Medicine: Honorable MentionThe vast majority of medically important pathogens infect their host across a body surface such as the skin, or across a mucosal tissue such as the respiratory tract or intestines, as these sites are the ones exposed to the external environment. By focusing on immunity at mucosal and body surfaces this book presents a fresh, new approach to the teaching of immunology. After an introduction to the basic structure of the immune system, the book looks at two important families of signalling molecules: cytokines and chemoki
• Titolo autorizzato: Immunology
• ISBN: 1-119-99864-6; 1-118-29962-0; 1-119-97988-9; 1-283-27287-3; 9786613272874; 0-470-09005-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910139601003321
• Lo trovi qui: Univ. Federico II