Practical microwave synthesis for organic chemists : strategies, instruments, and protocols / / C. Oliver Kappe, Doris Dallinger, and S. Shaun Murphree

• Autore: Kappe C. Oliver
• Pubblicazione: Weinheim, Germany : , : Wiley-VCH, , [2009]; ©2009
• Descrizione fisica: 1 online resource (311 p.)
• Disciplina: 547.2
• Soggetto topico: Microwave devices; Organic compounds - Synthesis
• Classificazione: VK 5500
• Persona (resp. second.): MurphreeS. Shaun; DallingerDoris
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Practical Microwave Synthesis for Organic Chemists; Contents; Preface; 1 Microwave Synthesis - An Introduction; References; 2 Microwave Theory; 2.1 Microwave Radiation; 2.2 Microwave Dielectric Heating; 2.3 Dielectric Properties; 2.4 Microwave versus Conventional Thermal Heating; 2.5 Microwave Effects; 2.5.1 Temperature Monitoring in Microwave Chemistry; 2.5.2 Thermal Effects (Kinetics); 2.5.3 Specic Microwave Effects; 2.5.4 Non-Thermal (Athermal) Microwave Effects; References; 3 Equipment Review; 3.1 Introduction; 3.2 Domestic Microwave Ovens ; 3.3 Dedicated Microwave Reactors for Organic Synthesis3.4 Single-Mode Instruments; 3.4.1 Biotage AB; 3.4.1.1 Initiator Platform; 3.4.1.2 Emrys Platform (2000-2004); 3.4.1.3 Chemspeed SWAVE; 3.4.2 CEM Corporation; 3.4.2.1 Discover Platform; 3.4.2.2 Explorer PLS Systems; 3.4.2.3 Voyager Systems; 3.4.2.4 Peptide Synthesizers; 3.4.3 Milestone s.r.l.; 3.5 Multimode Instruments; 3.5.1 Anton Paar GmbH; 3.5.1.1 Rotors and Vessels; 3.5.2 Biotage AB; 3.5.3 CEM Corporation; 3.5.3.1 MARS Scale-Up System Accessories; 3.5.3.2 MARS Parallel System Accessories; 3.5.4 Milestone s.r.l. ; 3.5.4.1 MultiSYNTH System3.5.4.2 MicroSYNTH Labstation; 3.5.4.3 StartSYNTH; 3.5.4.4 Scale-Up Systems; 3.5.4.5 RotoSYNTH; References; 4 Microwave Processing Techniques; 4.1 Solvent-Free Reactions; 4.2 Phase-Transfer Catalysis; 4.3 Open- versus Closed-Vessel Conditions; 4.4 Pre-Pressurized Reaction Vessels; 4.5 Non-Classical Solvents; 4.5.1 Water as Solvent; 4.5.2 Ionic Liquids; 4.6 Passive Heating Elements; 4.7 Processing Techniques in Drug Discovery and High-Throughput Synthesis; 4.7.1 Automated Sequential versus Parallel Processing; 4.7.2 High-Throughput Synthesis Methods ; 4.7.2.1 Solid-Phase Synthesis4.7.2.2 Soluble Polymer-Supported Synthesis; 4.7.2.3 Fluorous-Phase Organic Synthesis; 4.7.2.4 Polymer-Supported Reagents, Catalysts and Scavengers; 4.8 Scale-Up in Batch and Continuous Flow; 4.8.1 Scale-Up in Batch and Parallel; 4.8.2 Scale-Up Using Continuous Flow Techniques; 4.8.3 Scale-Up Using Stop Flow Techniques; 4.8.4 Flow-Through Techniques using Microreactors; References; 5 Starting With Microwave Chemistry; 5.1 Why Use Microwave Reactors?; 5.2 Getting Started-Method Development; 5.2.1 Open or Closed Vessels?; 5.2.2 Choice of Solvent ; 5.2.3 Temperature, Time and Microwave Power5.2.4 Microwave Instrument Software; 5.2.5 Reaction Optimization; 5.3 Additional Aspects; 5.3.1 Temperature Measurement; 5.3.2 Simultaneous Cooling; 5.3.3 Filling Volume; 5.3.4 The Importance of Stirring; 5.3.5 Pressure Release; 5.3.6 Inert Atmosphere; 5.3.7 Multiple Heating Steps; 5.3.8 Reaction Monitoring; 5.3.9 Reaction Scale versus Instrument; 5.4 Equipment/Maintenance; 5.5 General Suggestions; 5.6 Safety Aspects; 5.7 Advantages and Limitations; 5.8 Frequently Asked Questions (FAQs); References; 6 Experimental Protocols ; 6.1 General Small-Scale Sealed-Vessel Microwave Processing
• Sommario/riassunto: With the novice user in mind, this beginner's guide explains the basics behind microwave technology, evaluates available instruments and reaction modes, and provides practical hints for every eventuality. Includes 27 detailed protocols for often-used reactions. From the contents: 1 Microwave Synthesis - An Introduction2 Microwave Theory3 Equipment Review4 Microwave Processing Techniques5 Starting With Microwave Chemistry6 Experimental Protocols6.1 General Small-Scale Sealed-Vessel Microwave Processing6.2 Reaction Optimization6.3 Library Generation6.4 R
• Titolo autorizzato: Practical microwave synthesis for organic chemists
• ISBN: 1-282-02141-9; 9786612021411; 3-527-62390-6; 3-527-62391-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830581803321
• Lo trovi qui: Univ. Federico II