Hydrogen sulfide : chemical biology basics, detection methods, therapeutic applications, and case studies / / edited by Michael D. Pluth

• Pubblicazione: Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2022]; ©2022
• Descrizione fisica: 1 online resource (645 pages)
• Disciplina: 615.91
• Soggetto topico: Hydrogen - Thermal properties
• Persona (resp. second.): PluthMichael D.
• Note generali: Includes index.
• Nota di contenuto: Intro -- Table of Contents -- Title Page -- Copyright -- Preface -- List of Contributors -- 1 Fundamental and Biologically Relevant Chemistry of H2S and Related Species -- List of Abbreviations -- 1.1 Introduction -- 1.2 The Chemical Biology of H2S -- 1.3 H2S Reactions with Other Sulfur Species -- 1.4 The Biochemical Utility of RSSH -- 1.5 Summary/Conclusion -- References -- 2 Signaling by Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) and the Interaction with Other Signaling Pathways -- List of Abbreviations -- 2.1 Introduction -- 2.2 Determination of the Endogenous Concentrations of H2S -- 2.3 H2S and H2Sn as Signaling Molecules -- 2.4 Crosstalk Between H2S and NO -- 2.5 Cytoprotective Effect of H2S, H2Sn, and H2SO3 -- 2.6 Energy Formation in Mitochondria with H2S -- 2.7 S‐Sulfurated Proteins and Bound Sulfane Sulfur in Cells -- 2.8 Regulating the Activity of Target Proteins by H2S and H2Sn -- 2.9 Perspectives -- Acknowledgments -- Author Disclosure Statement -- References -- 3 Persulfides and Their Reactions in Biological Contexts -- List of Abbreviations -- 3.1 Persulfides Are Key Intermediates in Sulfur Metabolism and Signaling -- 3.2 Persulfides Are Formed in Biological Systems through Different Pathways -- 3.3 Persulfides Are More Acidic Than Thiols -- 3.4 Persulfides Are Stronger Nucleophiles Than Thiols -- 3.5 Persulfidation Protects Against Irreversible Oxidation -- 3.6 Persulfides Interact with Metals and Metalloproteins -- 3.7 Persulfides Have Electrophilic Character in Both Sulfur Atoms -- 3.8 Persulfides Are Efficient One‐Electron Reductants -- 3.9 Concluding Remarks -- References -- Notes -- 4 Hydrogen Sulfide, Reactive Nitrogen Species, and "The Joy of the Experimental Play*" -- 4.1 Introduction -- 4.2 Basic Physicochemical Properties of Nitric Oxide and Its Biological Relevant Metabolites. ; 4.3 Basic Physicochemical Properties of H2S and Its Biological Relevant Metabolites -- 4.4 Inorganic Sulfur-Nitrogen Compounds -- 4.5 Putative Biological Relevance of the NO/H2S Chemical Interaction -- 4.6 Summary and Conclusions -- Acknowledgment -- References -- Note -- 5 H2S and Bioinorganic Metal Complexes -- List of Abbreviations -- 5.1 Introduction -- 5.2 Basic Ligative Properties of H2S/HS− -- 5.3 H2S and Heme Iron -- 5.4 H2S and Nonheme Iron -- 5.5 H2S Chemistry with Other Metals -- 5.6 H2S Sensing with Transition Metal Complexes -- 5.7 Summary -- Acknowledgments -- References -- 6 Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method -- List of Abbreviations -- 6.1 Introduction -- 6.2 Monobromobimane: An Optimal Method of Bioavailable Sulfur Detection -- 6.3 Procedures -- 6.4 Caveats and Considerations -- Acknowledgment -- Disclosures -- References -- 7 Fluorescent Probes for H2S Detection: Cyclization‐Based Approaches -- List of Abbreviations -- 7.1 Introduction -- 7.2 General Design of Nucleophilic Reaction‐Cyclization Based Fluorescent Probes -- 7.3 Conclusions and Perspectives -- Acknowledgments -- References -- 8 Fluorescent Probes for H2S Detection: Electrophile‐Based Approaches -- 8.1 Introduction -- 8.2 Selected Probes Based on Different Reaction Types -- 8.3 Conclusion and Future Prospects -- References -- 9 Fluorescent Probes for H2S Detection: Metal‐Based Approaches -- 9.1 Introduction -- 9.2 Metal Displacement Approach -- 9.3 Coordinative‐Based Approach -- 9.4 H2S‐Mediated Reduction of the Metal Center -- 9.5 Conclusions and Future Outlooks -- References -- 10 H2S Release from P S and Se-S Motifs -- List of Abbreviations -- 10.1 Introduction -- 10.2 H2S Release from P S Motifs -- 10.3 H2S Release from Se-S Motifs -- 10.4 Acyl Selenylsulfides: Structural Modifications and Activity of Analogs. ; 10.5 Conclusions -- References -- 11 Hydrogen Sulfide: The Hidden Player of Isothiocyanates Pharmacology -- 11.1 Organic Isothiocyanates as H2S‐Donors -- 11.2 Organic ITCs and Cardiovascular System -- 11.3 Chemopreventive Properties of ITCs -- 11.4 Anti‐nociceptive Effects of ITCs -- 11.5 Anti‐inflammatory and Antiviral Effects of ITCs -- 11.6 Conclusion -- Acknowledgment -- References -- 12 Persulfide Prodrugs -- List of Abbreviations -- 12.1 Introduction -- 12.2 Persulfide Prodrugs -- 12.3 Challenges in Persulfide Prodrug Design and Potential Therapeutic Applications -- References -- 13 COS‐Based H2S Donors -- 13.1 Introduction -- 13.2 Properties of COS -- 13.3 COS‐Based H2S Delivery -- 13.4 Conclusions and Outlook -- Acknowledgments -- References -- 14 Light‐Activatable H2S Donors -- 14.1 Introduction -- 14.2 Photophysical and Photochemical Concepts -- 14.3 Phototherapeutic Window -- 14.4 Light Sources -- 14.5 (Photo)Physical Properties of H2S -- 14.6 Mechanisms and Examples of H2S Photorelease -- 14.7 Outlook -- Acknowledgment -- References -- 15 Macromolecular and Supramolecular Approaches for H2S Delivery -- List of Abbreviations -- 15.1 Introduction -- 15.2 H2S‐Donating Linear Polymers -- 15.3 H2S Delivery from Branched and Graft Polymer Topologies -- 15.4 Polymer Micelles for H2S Delivery -- 15.5 Polymer Networks for Localized H2S Delivery -- 15.6 Other Polymeric Systems for the Encapsulation of H2S Donors -- 15.7 H2S Release via Supramolecular Systems -- 15.8 Conclusions and Future Perspectives -- References -- 16 H2S and Hypertension -- List of Abbreviations -- 16.1 Hypertension, Vascular Homeostasis and Mediators Controlling Blood Pressure -- 16.2 Generation of H2S in the Cardiovascular System -- 16.3 Relevance of H2S in Hypertension -- 16.4 Conclusions -- References -- 17 H2S Supplementation and Augmentation: Approaches for Healthy Aging. ; List of Abbreviations -- 17.1 Introduction and Background -- 17.2 Hydrogen Sulfide Metabolism and Applications in Non‐mammalian Aging -- 17.3 Hydrogen Sulfide Metabolism and Applications in Nonhuman Mammalian Aging -- 17.4 Hydrogen Sulfide Metabolism and Applications in Human Aging and Aging‐Related Disorders -- 17.5 Conclusions and Summary -- Acknowledgments -- References -- 18 Aberrant Hydrogen Sulfide Signaling in Alzheimer's Disease -- List of Abbreviations -- 18.1 Introduction -- 18.2 Alzheimer's Disease -- 18.3 Therapeutic Avenues -- Acknowledgments -- References -- 19 Multifaceted Actions of Hydrogen Sulfide in the Kidney -- List of Abbreviations -- 19.1 Introduction -- 19.2 H2S Synthesis in the Kidney -- 19.3 H2S and Kidney Physiology -- 19.4 H2S and the Aging Kidney -- 19.5 H2S and Acute Kidney Injury (AKI) -- 19.6 H2S in Chronic Kidney Disease (CKD) -- 19.7 H2S and Preeclampsia -- 19.8 H2S and Genitourinary Cancers -- 19.9 Conclusion and Future Directions -- Acknowledgments -- References -- Index -- End User License Agreement.
• Sommario/riassunto: "The first section focuses on general concepts related to H2S and interactions with other reactive species in biological systems. The second section discusses methods of measuring and detecting H2S in complex biological environments. Topics covered in this second section include persulfidation, ion channel regulation, enzyme activation, and more. The third section covers methods for delivering H2S in biological environments and in response to different stimuli. The fourth and final section includes case studies on the impacts of exogenous H2S delivery in clinically relevant systems. The points of this section encompass a broad array of pharmacologically relevant systems in which H2S is established or predicted to play an important role"--
• Titolo autorizzato: Hydrogen sulfide
• ISBN: 1-119-79990-2; 1-119-79988-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910829823203321
• Lo trovi qui: Univ. Federico II
• Serie: Wiley Series in Drug Discovery and Development