Pizzo and Poplack's pediatric oncology [[electronic resource] /] / editors, Susan M. Blaney, MD, Professor, Hematology-Oncology Section, Baylor College of Medicine, Deputy Director, Texas Children's Cancer Center and Hematology Centers, Texas Children's Hospital, Houston, Texas, Peter C. Adamson, MD, Professor of Pediatrics and Pharmacology, Perelman School of Medicine, The University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Lee J. Helman, MD, Professor, Pediatrics and Medicine, Keck School of Medicine, University of Southern California, Head, Basic and Translational Research, Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California

• Pubblicazione: Philadelphia, : Wolters Kluwer Health, 2021
• Edizione: 8th ed.
• Descrizione fisica: 1 online resource (3044 pages)
• Disciplina: 618.92/994
• Soggetto topico: Tumors in children; Neoplasms; Child; Infant
• Altri autori: BlaneySusan M AdamsonPeter C HelmanL (Lee)
• Note generali: Revised edition of: Principles and practice of pediatric oncology. Seventh edition. [2016].
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Title Page -- Copyright Page -- Section 1 Biological Basis of Childhood Cancer -- 1 Epidemiology of Childhood Cancer -- Cancer Surveillance and Descriptive Epidemiology -- Analytic Epidemiology -- Summary and Future Considerations -- 2 Heredity and Childhood Cancer -- Constitutional Chromosomal Abnormalities -- Structural Chromosomal Abnormalities -- Overgrowth Disorders and Imprinting Errors -- Autosomal Dominant Disorders -- Autosomal Recessive Disorders -- Issue in Genetic Testing for the Pediatric Oncology Patient -- 3 Molecular and Genetic Basis of Childhood Cancer -- General Nature of Cancer-Associated Genetic Aberrations -- Comprehensive Analysis of the Cancer Genome -- Germline Mutations -- Somatically Acquired Chromosomal Aberrations and Mutation -- Gross Chromosomal Rearrangements -- Oncogenic Consequences of Gross Chromosomal Rearrangements-General Themes -- Chromosomal Translocations Lead to Activation of Proto-Oncogenes and Generation of Oncogenic Fusion Genes -- Chromosomal Deletion Leads to Inactivation of Tumor Suppressor Genes -- Gene Amplification -- Point Mutations Leading to Gene Activation or Inactivation -- Comprehensive Genomic Studies of Pediatric Tumors -- Mechanisms of Malignant Cell Transformation, Growth, and Clonal Expansion -- Outlook for Molecularly Targeted Therapies -- Summary -- 4 Biology of Childhood Cancer -- Gene Regulation -- Protein Regulation -- Signal Transduction -- Cell Proliferation -- Programmed Cell Death -- Cancer Metabolism -- Metastasis and the Tumor Microenvironment -- 5 Tumor Immunology of Childhood Cancer -- Overview of the Immune System -- Modern Concepts of Immune Surveillance -- T-Cell Recognition of Cancer -- Innate Immune Cells and the Tumor Microenvironment -- Immune Function in Cancer Patients -- Immunotherapy of Cancer -- Summary and Future Directions. ; Section 2 Diagnosis and Evaluation of the Child with Cancer -- 6 Clinical Assessment and Differential Diagnosis of Suspected Childhood Cancer -- Children at Risk -- Time to Diagnosis -- Differential Diagnosis -- Establishing the Diagnosis -- Summary -- 7 Pathology and Molecular Diagnosis of Leukemias and Lymphomas -- Introduction -- Ancillary Studies -- Lymphoblastic Leukemia -- Myeloid Neoplasms -- Mature Lymphoid Neoplasms -- Histiocytic Disorders -- 8 Diagnostic Pathology of Pediatric Solid and Central Nervous System Malignancies -- Introduction -- Brief Pathologic Classification of Pediatric Solid Tumors -- Traditional Approaches to Childhood Solid Tumor Diagnosis -- Molecular Genetic Evaluation of Childhood Cancer -- Integrated Diagnostic Molecular Pathology of Pediatric Solid Tumors -- The Holistic Cancer Genome -- DNA -- RNA -- Emerging Technologies for Diagnosis -- The Future of Pediatric Cancer Diagnosis -- 9 Imaging Studies in the Diagnosis of Childhood Cancer -- Relative Merits of Available Imaging Procedures -- General Concepts of Pediatric Tumor Imaging -- Future Directions -- Section 3 Principles of Multimodal Therapy -- 10 General Principles of Chemotherapy -- Principles of Cancer Chemotherapy -- Clinical Pharmacology of Anticancer Drugs -- Alkylating Agents -- Nonclassical Alkylating Agents -- Antimetabolites -- Purine Antimetabolites -- Pyrimidine Antimetabolites -- Topoisomerase Inhibitors -- Tubulin Inhibitors -- Miscellaneous Agents -- Small-Molecule Pathway Inhibitors -- Therapeutic Antibodies -- Perspectives -- 11 General Principles of Cellular Immunotherapy -- T Cells -- Natural Killer Cells -- γδ Thymus-Derived T Cells -- Invariant Natural Killer T Cells -- Strategies to Improve Adoptive Cellular Therapies -- Conclusions -- 12 General Principles of Targeted Therapy -- Introduction. ; Basic Principles for the Clinical Development of Molecularly Targeted Agents -- Therapies Targeted to Apoptosis Pathways -- Targeting Extracellular Survival Signaling Pathways -- Targeting Development, Differentiation, and Other Intracellular Processes -- Targeting Angiogenesis -- Conclusions -- 13 General Principles of Hematopoietic Stem Cell Transplantation -- Autologous Transplantation-High-Dose Chemotherapy with Hematopoietic Stem Cell (Hsc) Rescue -- Allogeneic Transplantation -- Allogeneic Hematopoietic Stem Cell Transplantation Preparative Regimens -- Transplantation for Leukemia -- Transplantation for Hodgkin Lymphoma (HL) and Non-Hodgkin Lymphoma (NHL) -- Transplantation for Solid Tumors -- Complications After Hematopoietic Stem Cell Transplantation -- Late Effects After Hematopoietic Stem Cell Transplantation -- Future Directions -- 14 General Principles of Radiation Oncology -- Biologic Basis of Radiation Therapy -- Physical Basis of Radiation Therapy -- Interactions of Radiation Therapy and Chemotherapy -- Radiation Effects on Normal Tissues -- 15 General Principles of Surgery -- Preoperative Considerations for the Oncologist -- Perioperative Considerations for the Oncologist -- Minimally Invasive Surgery -- Section 4 Management of Common Cancers of Childhood -- 16 Acute Lymphoblastic Leukemia -- Epidemiology -- Genetic Risk Factors -- Environmental Risk Factors -- Pathogenesis -- Classification of Acute Lymphoblastic Leukemia -- Molecular Genomics of Acute Lymphoblastic Leukemia -- Pharmacogenetics -- Clinical Presentation -- Assessing Treatment Response -- Prognostic Factors -- Treatment -- Treatment of Relapse -- Late Effects of Treatment -- Future Challenges -- 17A Acute Myeloid Leukemia and Myelodysplastic Syndromes -- Historical Background and Definitions. ; Epidemiology of Pediatric Acute Myeloid Leukemia and Myelodysplastic Syndrome -- Biologic Basis of Acute Myeloid Leukemia and Myelodysplastic Syndrome: From Normal Progenitors to Leukemia -- Methodologies for Classifying Myeloid Malignancies -- Defining Subtypes: Evolution of Diagnostic Classification of Myeloid Malignancies -- Clinical and Laboratory Presentation -- Prognostic Factors and Implications of Risk Group Stratification on Treatment -- Evolution of Risk Adapted Therapy -- Unique Aml Subtypes and Settings -- The Treatment of Relapsed or Refractory Acute Myeloid Leukemia -- Survivorship -- 17B Myeloproliferative Neoplasms of Childhood -- Chronic Myeloid Leukemia -- Juvenile Myelomonocytic Leukemia -- Polycythemia Vera and Essential Thrombocythemia -- 18 Hodgkin Lymphoma -- Biologic Considerations -- Epidemiology, Pathogenesis & -- Pathology -- Clinical Presentation -- Treatment and Outcome -- Nodular Lymphocyte Predominant Hodgkin Lymphoma -- Approach to Patients with Primary Refractory Disease or Relapse of Hodgkin Lymphoma -- Late Effects -- Future Considerations -- 19 Malignant Non-Hodgkin Lymphomas in Children -- Non-Hodgkin Lymphoma Overview -- NHL Cellular Classifications: Specific Biologic and Clinical Considerations -- Conclusions -- Management Summary -- 20 Lymphoproliferative Disorders and Malignancies Related to Immunodeficiencies -- Viral Pathogens and the Development of Malignancies -- Epstein-Barr Virus and Malignancies -- Human herpesvirus-8 and Malignancies in Immunodeficient Patients -- Malignancies in Primary Immunodeficiencies -- Secondary Immunodeficiency and Cancer -- Malignancies in the Posttransplant Patient -- Summary -- 21 Histiocytoses -- Langerhans Cell Histiocytosis -- Hemophagocytic Lymphohistiocytosis -- Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease) -- Juvenile Xanthogranuloma. ; Malignant Histiocytic Diseases -- Summary -- Management Summary -- 22A Gliomas, Ependymomas, and Other Nonembryonal Tumors of the Central Nervous System -- Epidemiology -- Inherited Syndromes Associated with Central Nervous System Tumors -- Ionizing Radiation and Central Nervous System Tumors -- Pathologic Classification of Central Nervous System Tumors -- Clinical Presentation -- Neuroimaging in Pediatric Central Nervous System Tumors: Current Status and Future Directions -- Neurosurgery: Diagnosis and Treatment -- Radiation Therapy -- Principles of Chemotherapy -- Ependymoma -- Low-Grade Gliomas -- Tumors of the Optic Pathway -- Supratentorial High-Grade Gliomas -- Brainstem Gliomas -- Craniopharyngioma -- Choroid Plexus Neoplasms -- Intramedullary Spinal Cord Tumors -- Sequelae of Treatment -- 22B Tumors of the Central Nervous System: Embryonal and Pineal Region Tumors -- Embryonal Tumors -- Medulloblastoma -- Atypical Teratoid/Rhabdoid Tumor -- Embryonal Tumors with Multilayered Rosettes -- Other Rare Embryonal Tumors -- Pineal Region Tumors -- Germ Cell Tumors -- 23 Neuroblastoma -- Epidemiology -- Genetic Predisposition -- Molecular Pathogenesis -- Pathology -- Clinical Presentation -- Paraneoplastic Syndromes -- Clinical and Laboratory Evaluation -- Staging and Treatment Response -- Prognostic Considerations -- Principals of Initial Therapy -- Late Effects -- Future Considerations -- 24 Renal Tumors -- Epidemiology -- Genetics and Molecular Biology -- Pathology -- Clinical Presentation and Diagnostic Workup -- Prognostic Factors -- Treatment of Wilms Tumor -- Clear Cell Sarcoma of the Kidney -- Malignant Rhabdoid Tumor -- Renal Cell Carcinoma -- Congenital Mesoblastic Nephroma -- 25 Rhabdomyosarcoma -- Epidemiology and Genetic Susceptibility -- Molecular Biology -- Animal Models -- Pathology -- Patterns of Spread and Clinical Presentation. ; Methods of Diagnosis.
• Sommario/riassunto: "This authoritative reference is a comprehensive resource on the biology and genetics of childhood cancer as well as its diagnosis, multimodal treatment, as well as long-term management of young patients with cancer. Also addressed are a broad array of topics on the supportive and psychosocial aspects of care of children and families. Covering virtually every aspect of the breadth and depth of childhood cancer, this reference provides expert guidance on state-of-the-art, multidisciplinary care for children and families"--
• Titolo autorizzato: Pizzo and Poplack's pediatric oncology
• ISBN: 1-9751-2481-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910794363003321
• Lo trovi qui: Univ. Federico II