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Lassa Fever : Viral Replication, Disease Pathogenesis, and Host Immune Modulations



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Autore: Ly Hinh Visualizza persona
Titolo: Lassa Fever : Viral Replication, Disease Pathogenesis, and Host Immune Modulations Visualizza cluster
Pubblicazione: Basel, Switzerland, : MDPI - Multidisciplinary Digital Publishing Institute, 2020
Descrizione fisica: 1 electronic resource (132 p.)
Soggetto topico: Research & information: general
Biology, life sciences
Soggetto non controllato: Lassa virus disease (LVD)
vaccine breadth
mimicry
B cell anergy
conserved antigens
Fc-gamma receptors
conformational antigens
broadly-neutralizing antibodies
focused immunity
dominant and subdominant epitopes
cross-restriction
Lassa virus
Z protein
late domain
PPXY
budding
release
matrix protein
phosphorylation
arenavirus
mass spectrometry
viral glycoprotein
viral entry
viral fusion
fusion protein
Lassa virus vaccine
ML29 vaccine
STAT-1-/- mice
Mopeia virus
interfering particles
Lassa fever
LASV
virus–host interactions
entry
replication
Lassa vaccine
replication-deficient MVA vector
VLP formation
single-dose efficacy
cell-mediated immunity
arenaviruses
viral hemorrhagic fevers
animal models
mammarenavirus
vaccine
virulence
pathogenesis
innate immunity
adaptive immunity
COVID-19
Persona (resp. second.): LyHinh
Sommario/riassunto: Lassa virus causes Lassa fever disease in several countries in West Africa, where it is estimated to infect up to half million people causing roughly five thousand deaths each year. This deadly virus has also been introduced in multiple occasions into the western world, including the United States, United Kingdom, Netherlands, Sweden, and Germany. Lassa virus infection, which is often misdiagnosed, can lead to a wide range of disease symptoms ranging from mild flu-like symptoms to bleeding disorders, multi-organ failure, and death. Despite some major discoveries made in recent years of research on Lassa fever, there are still many unresolved key issues that hamper the development of effective vaccines and therapies. Some of these issues include a detailed understanding of the viral and participating host factors in completing the virus life cycle, in mediating disease pathogenesis or protection, and in activating or suppressing host immune responses against virus infection. This book is devoted to understanding some of these important issues. Expert and timely contributions in the form of editorial and original research and review articles on Lassa fever viral replication, disease pathogenesis and protection, host immune modulations, and other related hot topics are presented in this publication.
Altri titoli varianti: Lassa Fever
Titolo autorizzato: Lassa Fever  Visualizza cluster
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910674050303321
Lo trovi qui: Univ. Federico II
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