Novel drug delivery systems for Chinese medicines / / Nianping Feng, Zhijun Yang, editors

• Pubblicazione: Gateway East, Singapore : , : Springer, , [2021]; ©2021
• Descrizione fisica: 1 online resource (342 pages)
• Disciplina: 615.6
• Soggetto topico: Drug delivery systems; Medicine, Chinese; Pharmacology; Gestió farmacèutica; Medicina xinesa
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): FengNianping; YangZhijun
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Editorial Board -- Preface -- Marketing Text -- Contents -- About the Editors -- Chapter 1: A Historical Overview and Concepts of Chinese Medicine Preparations and Novel Delivery Systems -- 1.1 Introduction -- 1.2 Characteristics of Chinese Medicines -- 1.2.1 Medicinal Materials´ Growing Areas and Geo-Authentic Medicinal Materials (Daodi Yaocai) -- 1.2.2 Harvesting of Chinese Medicinal Materials -- 1.2.3 Processing of Medicinal Materials -- 1.2.4 Compatibility of Chinese Medicines -- 1.3 Active Substances of Chinese Medicine Preparations -- 1.3.1 Diversity of the Active Substances of Chinese Medicine Preparations -- 1.3.1.1 Diversity of Source -- 1.3.1.2 Diversity of Ingredients and Effects -- 1.3.1.3 Diversity of Factors Affecting the Quality -- 1.3.2 Types of Active Substances of Chinese Medicine Preparations -- 1.3.2.1 Decoction Pieces -- 1.3.2.2 Volatile Oil and Fatty Oil -- 1.3.2.3 Extracts -- 1.3.2.4 Active Ingredients -- 1.3.3 Preparation of Active Substances of Chinese Medicine Preparations -- 1.3.3.1 Pretreatment of Chinese Medicinal Materials -- 1.3.3.2 Extraction -- 1.3.3.3 Separation and Purification -- 1.3.3.4 Concentration and Drying -- 1.4 NDDS of Chinese Medicines -- 1.4.1 Design of NDDS for Chinese Medicines -- 1.4.2 NDDS Technologies Used in Chinese Medicines -- 1.4.2.1 Oral Sustained-Release Systems -- 1.4.2.2 Sustained-Release Systems for Intravenous Administration -- 1.4.2.3 In Situ Forming Drug Delivery Systems -- 1.4.2.4 Transdermal Drug Delivery Systems -- 1.4.2.5 Mucosal Drug Delivery Systems -- 1.4.2.6 Targeted Drug Delivery Systems -- 1.4.2.7 Smart Drug Delivery Systems -- 1.5 Novel Pharmaceutical Technologies for Chinese Medicines -- 1.5.1 Inclusion Compounds -- 1.5.2 Solid Dispersion -- 1.5.3 Microcapsules and Microspheres -- 1.5.4 Pharmaceutical Nanotechnologies -- 1.6 Multi-Component Drug Delivery System. ; 1.7 Conclusions -- References -- Chapter 2: Multi-Component Drug Delivery Systems for Chinese Medicines Based on the TCM Theory -- 2.1 Introduction -- 2.2 Properties of Components -- 2.2.1 Medicine Properties of Components -- 2.2.1.1 Four Natures of Components -- 2.2.1.2 Five Tastes of Components -- 2.2.1.3 Channel Tropism of Components -- 2.2.1.4 Ascending and Descending of Components -- 2.2.1.5 Toxic of Components -- 2.2.2 Physical Properties of Components -- 2.2.2.1 Physicochemical Properties and Structure Characteristics of Components -- 2.2.2.2 ADME Properties and Pharmacokinetic Characteristics of Components -- 2.2.2.3 Pharmaceutical Properties of Components -- 2.3 Unit Preparation Techniques for Components -- 2.3.1 Solubilization of Difficult Soluble Components -- 2.3.2 Strategies to Improve or to Promote the Permeability of Components -- 2.3.2.1 Increasing Mucosal Permeability of Components -- 2.3.2.2 Promoting Cellular Permeability of Components -- 2.3.2.3 Other Ways to Improve the Permeability of Components -- 2.3.3 New Ideas for the Design of Component Unit Preparation -- 2.3.3.1 Utilization of Physicochemical Synergy Between Components -- 2.3.3.2 Using Suitable Carrier to Transport Components -- 2.4 Design of MCDDS -- 2.4.1 Design of MCDDS Based on MPCs -- 2.4.1.1 Design Based on CFN -- 2.4.1.2 Design Based on CFT -- 2.4.1.3 Design Based on CCT -- 2.4.1.4 Design Based on CAD -- 2.4.1.5 Design Based on CT -- 2.4.2 Design Based on the Characteristics of a Disease -- 2.4.2.1 According to the Priority of Syndromes of a Disease -- 2.4.2.2 According to the Rhythm of Pathophysiology -- 2.4.3 Difficulties in the Design of MCDDS -- 2.5 Establishing a Scientific Evaluation System for MCDDS -- 2.5.1 The Evaluations of MCDDS in Vitro -- 2.5.2 The Evaluations for MCDDS in Vivo -- 2.5.3 The Evaluations for Toxicity and Side Effects of MCDDS. ; 2.6 Conclusions and Prospects -- References -- Chapter 3: Sustained-Release Drug Delivery Systems of Chinese Medicines -- 3.1 Introduction -- 3.2 Sustained Delivery of Various Bioactive Ingredients from Chinese Medicine -- 3.2.1 Sustained Delivery of Bioactive Alkaloids -- 3.2.2 Sustained Delivery of Bioactive Glycosides -- 3.2.3 Sustained Delivery of Bioactive Phenolic Acids -- 3.2.4 Sustained Delivery of Bioactive Polysaccharides -- 3.2.5 Others -- 3.3 Sustained-Release Preparations of TCM Compound Recipes -- 3.3.1 Membrane-Controlled Type -- 3.3.2 Matrix Type -- 3.3.3 Osmotic Type -- 3.3.4 Intragastric Floating Type -- 3.4 The Quality Evaluation of Sustained-Release DDSs of Chinese Medicines -- 3.5 Conclusion -- References -- Chapter 4: Transdermal Delivery of Chinese Medicine -- 4.1 Introduction -- 4.2 Chinese Medicine Essential Oils as Penetration Enhancers -- 4.2.1 Mechanism of Penetration Enhancement -- 4.2.2 Role of ``Four Natures´´ -- 4.2.3 Percutaneous Absorption of EO Components -- 4.3 Techniques in Increasing Physical Penetration -- 4.3.1 Microneedles -- 4.3.2 Iontophoresis -- 4.3.3 Sonophoresis -- 4.3.4 Cupping Therapy -- 4.4 Nanocarriers for Transdermal Delivery of Chinese Medicine -- 4.4.1 Liposomes -- 4.4.2 Nanoparticles -- 4.4.3 Nanoemulsions -- 4.5 Transdermal Evaluation Technique -- 4.6 Conclusion -- References -- Chapter 5: The Contribution of Traditional Chinese Medicine Compound in Nasal Drug Delivery System -- 5.1 Nasal Therapy Under Traditional Chinese Medicine Theory -- 5.2 The Understanding of Nasal Therapy in Western Natural Medicine -- 5.3 Development in Anatomy -- 5.4 Development of Modern Preparations -- 5.4.1 Nasal Drops -- 5.4.2 Aerosols and Sprays -- 5.4.3 Gelling Agent and in Situ Gel -- 5.4.4 Microemulsion -- 5.4.5 Liposome -- 5.4.6 Nanoparticles -- 5.4.7 Summary. ; 5.5 The Combination of Traditional Chinese Medicine and Modern Preparations -- 5.5.1 Inclusive Compound Preparation Technology -- 5.5.2 Solid Dispersion Technology -- 5.5.3 Microsphere Preparation Technology -- 5.5.4 Nanotechnology -- 5.6 Problems and Prospects -- 5.6.1 Problems -- 5.6.2 Prospects -- References -- Chapter 6: Brain-Targeting Drug Delivery Systems for Chinese Medicines -- 6.1 Introduction -- 6.2 Physiological Barrier of the Brain for Drug Delivery -- 6.3 Brain-Targeting Drug Delivery Strategies for Chinese Medicines -- 6.3.1 Intranasal Drug Delivery Systems -- 6.3.2 Brain Penetration Enhancers -- 6.3.2.1 Aromatic Penetration Enhancers from Chinese Medicines -- 6.3.2.2 Non-aromatic Penetration Enhancers from Chinese Medicines -- 6.3.2.3 Vasoactive Substances -- 6.3.3 Prodrug Delivery Systems -- 6.3.3.1 Ligand Modification -- 6.3.3.2 Chemical Modification -- 6.3.4 Nanoparticle Drug Delivery Systems -- 6.3.5 Other Drug Delivery Systems -- 6.4 Conclusion -- References -- Chapter 7: Chinese Herbal Medicine and Targeted Delivery Strategy for the Treatment of Kidney Disease -- 7.1 Introduction -- 7.2 Structure and Physiological Function of the Kidney -- 7.2.1 Structure -- 7.2.1.1 Renal Corpuscle -- 7.2.1.2 Renal Tubules -- 7.3 Chinese Herbal Medicine in the Treatment of CKD -- 7.3.1 Huangqi (Astragali Radix) -- 7.3.2 Dahuang (Rhei Radix et Rhizoma) -- 7.3.3 Danshen (Salviae Miltiorrhizae Radix et Rhizoma) -- 7.3.4 Leigongteng (Radix et Rhizoma Tripterygii) -- 7.3.5 Danggui (Angelica Sinensis Radix) -- 7.3.6 Others -- 7.4 Kidney-Targeted Delivery Strategy -- 7.4.1 Targeting Glomerulus -- 7.4.1.1 Targeting Mesangial Cell -- 7.4.1.2 Targeting Podocytes -- 7.4.2 Targeting Proximal Tubules -- 7.4.2.1 Targeting Megalin and Cubilin Receptors -- 7.4.2.2 Targeting Folate Receptor -- 7.5 Conclusions -- References. ; Chapter 8: Liposomes and Their Application in the Delivery of Herbal Active Ingredients -- 8.1 History of Liposomes -- 8.2 The Composition of Liposomes -- 8.2.1 Liposomal Vesicles (Lipid Vesicles) -- 8.2.2 The Composition of Liposomes -- 8.3 Preparation -- 8.3.1 Relationship Between the Type and the Preparation Method -- 8.3.2 Method of Preparation -- 8.3.3 Surface Modification -- 8.3.4 Loading or Entrapment of Drugs -- 8.4 The Qualities of Liposomes -- 8.4.1 Liposomes Membrane -- 8.4.2 Entrapped Volume and Capture Efficiency -- 8.4.3 The Morphology and Size of Liposomes -- 8.4.3.1 Selective Permeability and Fluidity Permeability -- 8.4.4 Charges, pH, and Calcium -- 8.4.5 Stability and Storage -- 8.5 The Application of Liposomes in Chinese Medicine -- 8.6 Conclusion -- References -- Chapter 9: Microparticulate Drug Delivery Systems for Chinese Medicines -- 9.1 Introduction -- 9.2 Types and Components of Microparticles of Chinese Medicine -- 9.2.1 Core Materials -- 9.2.2 Coating Materials -- 9.3 Fabrication of Microparticulate DDS of Chinese Medicine -- 9.3.1 Solvent Evaporation -- 9.3.2 Coacervation -- 9.3.3 Spray Drying Method -- 9.3.4 Other Methods -- 9.3.4.1 Supercritical Fluid Technique -- 9.3.4.2 Hydrogel-Template Technique -- 9.4 Characterization of Microparticulate DDS of Chinese Medicine -- 9.4.1 Particle Size and Size Distribution -- 9.4.2 Morphology and Structure -- 9.4.3 Drug Loading Capacity and Release Pattern -- 9.4.4 Drug-Excipient Interaction -- 9.5 Application of Microparticulate DDS of Chinese Medicine -- 9.5.1 Solidification and Powderization -- 9.5.2 Prolonged-Release for Improved Bioavailability -- 9.5.3 Targeted or Site-Specific Drug Delivery -- 9.5.4 Biomedical Engineering -- 9.5.5 Other Applications -- 9.6 Conclusion and Prospects -- References -- Chapter 10: Hydrogels for Delivery of Chinese Medicines -- 10.1 Introduction. ; 10.2 Effects of Hydrogels in Improving In Vivo Efficacies of Drugs.
• Titolo autorizzato: Novel drug delivery systems for Chinese medicines
• ISBN: 981-16-3444-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910512306903321
• Lo trovi qui: Univ. Federico II