Transduction channels in sensory cells [[electronic resource] /] / edited by Stephan Frings and Jonathan Bradley

• Pubblicazione: Weinheim, : Wiley-VCH, c2004
• Descrizione fisica: 1 online resource (324 p.)
• Disciplina: 571.74
• Soggetto topico: Cellular signal transduction; Senses and sensation; Molecular biology
• Soggetto genere / forma: Electronic books.
• Altri autori: FringsStephan BradleyJonathan <1961->
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Transduction Channels in Sensory Cells; Table of Contents; Preface; List of Contributers; 1 The Molecular Basis of Touch Sensation as Modeled in Caenorhabditis elegans; Abstract; 1.1 Introduction; 1.2 Features of the C. elegans Model System; 1.3 Mechanosensation Is a Major Mechanism by Which C. elegans Senses Its Environment; 1.4 Gentle Body Touch; 1.4.1 The Touch Receptor Neurons; 1.4.2 Ultrastructural Features of the Touch Receptor Neurons; 1.4.2.1 Touch Cell-specific Microtubules; 1.4.2.2 The Extracellular Mantle; 1.4.3 Genetic and Molecular Analysis of Body Touch ; 1.4.3.1 mec-4 and mec-10 Ion Channel Subunits Form Na(+) Channels1.4.3.2 MEC-4 at the Molecular Level; 1.4.4 The Candidate Mechanotransducing Channel is a Heteromultimeric Complex; 1.4.4.1 MEC-4 and MEC-10 Form a Functional Ion Channel; 1.4.4.2 MEC-2 Is a Stomatin-like Protein That May Help Tether the MEC-4/MEC-10 Channel to the Membrane Bilayer and/or the Cytoskeleton; 1.4.4.3 MEC-6 Is a Transmembrane Paraoxonase-like Protein That Controls MEC Channel Activity; 1.4.5 Intracellular Proteins Needed for Touch Transduction; 1.4.6 Extracellular Proteins Needed for Touch Transduction ; 1.4.6.1 MEC-11.4.6.2 MEC-5; 1.4.6.3 MEC-9; 1.4.7 The MEC Channel Functions Specifically in Neuronal Responses to Gentle Touch; 1.4.7.1 Test of a Key Hypothesis; 1.4.7.2 Additional Insights Revealed by Imaging In Vivo Ca(2+) Changes in Responding Touch Neurons; 1.4.8 Summary: A Molecular Model for Gentle-touch Sensation; 1.4.8.1 How Touch Is Sensed to Elicit a Specific Behavioral Response; 1.4.8.2 Notes on the Working Model; 1.5 The C. elegans Degenerin Family: A Global Role of Degenerin Channels in Mechanotransduction?; 1.5.1 unc-105; 1.5.2 unc-8 and del-1 ; 1.5.2.1 A Stomatin Partner for the UNC-8 Channel Suggests a Common Composition of Degenerin Channels1.5.2.2 Trp Channels May Also Contribute to Mechanosensory Functions in C. elegans; 1.5.2.3 Fly and Mouse Neuronal DEG/ENaCs Influence Mechanotransduction, Supporting Conserved Roles for This Family of Proteins; 1.6 Concluding Remarks; Acknowledgments; References; 2 Transduction Channels in Hair Cells; 2.1 Introduction; 2.2 Gating Mechanism: Channel Kinetics; 2.2.1 Tip Links and Gating Springs; 2.2.2 Gating Compliance; 2.2.3 Three-state Channel Schemes; 2.3 Ionic Selectivity ; 2.3.1 Blocking Compounds2.4 MET Channel Adaptation; 2.4.1 Ca(2+) Regulation of Adaptation; 2.4.2 The Function of Adaptation; 2.5 Single-channel Conductance; 2.5.1 Number of MET Channels Per Stereocilium; 2.6 The MET Channel as a Member of the TRP Family; 2.6.1 Properties of TRPV Channels; 2.7 Conclusions; Acknowledgments; References; 3 Acid-sensing Ion Channels; 3.1 Introduction; 3.2 ASICs and the DEG/ENaC Superfamily; 3.3 Amino Acid Structure; 3.4 Assembly Into Channels; 3.5 Pharmacology; 3.6 Gating; 3.7 Proposed Sensory Functions; 3.7.1 Pain/Nociception; 3.7.2 Mechanosensation; 3.7.3 Taste ; 3.8 CNS ASICs
• Sommario/riassunto: This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals.
• Titolo autorizzato: Transduction channels in sensory cells
• ISBN: 1-280-52012-4; 9786610520121; 3-527-60391-3; 3-527-60497-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910144557703321
• Lo trovi qui: Univ. Federico II