Evolutionary biology, cell-cell communication, and complex disease / / John S. Torday, Virender K. Rehan

• Autore: Torday John S
• Pubblicazione: Hoboken, N.J., : Wiley-Blackwell, c2012
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (186 p.)
• Disciplina: 572.8
• Soggetto topico: Molecular genetics; Molecular evolution; Cell interaction; Pathology, Molecular
• Altri autori: RehanVirender K
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: EVOLUTIONARY BIOLOGY, CELL-CELL COMMUNICATION, AND COMPLEX DISEASE; CONTENTS; PREFACE; ABOUT THE AUTHORS; 1: THE CELLULAR ORIGIN OF VERTEBRATES; THE ORIGINS OF UNICELLULAR LIFE ON EARTH; PROKARYOTES VERSUS EUKARYOTES; COEVOLUTION OF TRAITS; CHOLESTEROL FACILITATES LIPID RAFTS FOR CELL-CELL COMMUNICATION; THE ENDOMEMBRANE SYSTEM; THE CELLULAR MECHANISM OF EVOLUTION; WHY EVOLVE?; CELL-CELL COMMUNICATION AND AGING; 2: REDUCING LUNG PHYSIOLOGY TO ITS MOLECULAR PHENOTYPES; HORMONAL ACCELERATION OF LUNG DEVELOPMENT; NEUTRAL LIPID TRAFFICKING AND LUNG EVOLUTION ; OTHER EXAMPLES OF CELLULAR COOPERATIVITYSUMMARY; 3: A CELL-MOLECULAR STRATEGY TO SOLVING THE EVOLUTIONARY PUZZLE; RATIONALE FOR CELL-MOLECULAR EVOLUTION; MECHANISM OF MAMMALIAN LUNG DEVELOPMENT; AVIAN LUNG STRUCTURE-FUNCTION RELATIONSHIP: THE EXCEPTION THAT PROVES THE RULE; DOES ONTOGENY RECAPITULATE PHYLOGENY? THE ROLE OF PTHRP IN LUNG DEVELOPMENT; INTERRELATIONSHIP BETWEEN PTHRP, DEVELOPMENT, PHYSIOLOGY, AND REPAIR: IS REPAIR A RECAPITULATION OF ONTOGENY AND PHYLOGENY?; 4: THE EVOLUTION OF CELL-CELL COMMUNICATION; CELL-CELL COMMUNICATION AS THE MECHANISTIC BASIS FOR EVOLUTIONARY BIOLOGY ; THE DARWINIAN BIOLOGIC SPACETIME CONTINUUM AND EINSTEIN'S VISION OF THE UNIVERSEREVERSE ENGINEERING OF PHYSIOLOGIC TRAITS AS A PORTAL FOR VIEWING EVOLUTION; CELL-CELL COMMUNICATION AS THE BASIS FOR THE EVOLUTION OF METAZOANS; UNDERSTANDING LUNG EVOLUTION FROM THE MIDDLE OUT; THE CELL-CELL COMMUNICATION MODEL OF LUNG EVOLUTION TRACES CONTEMPORARY PHENOTYPES BACK TO ANCESTRAL PHENOTYPES; PREDICTIVE VALUE OF THE LUNG CELL-CELL COMMUNICATION MODEL FOR UNDERSTANDING THE EVOLUTION OF PHYSIOLOGIC SYSTEMS ; SEXUAL DIMORPHISM OF LUNG DEVELOPMENT: A CASE STUDY IN CELL-CELL COMMUNICATION AND EVOLUTIONARY PLASTICITYANDROGEN AFFECTS THE EXPRESSION OF GROWTH FACTORS INVOLVED IN LUNG DEVELOPMENT; EVIDENCE FOR AN ASSOCIATION BETWEEN STEROID-RESISTANT/RESPONSIVE PHENOTYPES AND HUMAN LYMPHOCYTE ANTIGEN (HLA) HAPLOTYPES; 5: HOW TO INTEGRATE CELL-MOLECULAR DEVELOPMENT, HOMEOSTASIS, ECOLOGY, AND EVOLUTIONARY BIOLOGY: THE MISSING LINKS; NEUTRAL THEORY VERSUS INTELLIGENT DESIGN; INTERNAL SELECTION THEORY; THE COUNTERINTUITIVE NATURE OF PHYSIOLOGY AND SOLUTION TO THE DEAD SEA SCROLLS PUZZLE ; THE CONTINUUM FROM MICROEVOLUTION TO MACROEVOLUTIONcis REGULATION AND ADAPTIVE EVOLUTION; EVOLUTION OF cis REGULATORY MECHANISMS; 6: FROM CELL-CELL COMMUNICATION TO THE EVOLUTION OF INTEGRATED PHYSIOLOGY; CELL-CELL SIGNALING AND ALVEOLAR DEVELOPMENT: A REDUCTIONIST APPROACH TO THE EVOLUTION OF PHYSIOLOGIC TRAITS; AN INTEGRATED, EMPIRIC, MIDDLE-OUT APPROACH TO PHYSIOLOGY; A MOLECULAR EVOLUTIONARY LINK BETWEEN THE LUNG AND THE KIDNEY?; THE BERNER HYPOTHESIS AND EMERGENCE OF THE ADIPOCYTE: THE EVOLUTIONARY ORIGINS OF THE LIPOFIBROBLAST; LUNG BIOLOGY AS A CIPHER FOR EVOLUTION ; DO STRETCH EFFECTS ON PTHRP EXPRESSION REFLECT ITS ROLE IN ADAPTING TO GRAVITY?
• Sommario/riassunto: An integrative view of the evolution of genetics and the natural world Even in this advanced age of genomics, the evolutionary process of unicellular and multicellular organisms is continually in debate. Evolutionary Biology, Cell-Cell Communication, and Complex Disease challenges current wisdom by using physiology to present an integrative view of the nature, origins, and evolution of fundamental biological systems. Providing a deeper understanding of the way genes relate to the traits of living organisms, this book offers useful information applying evolutionary biology, functional ge
• Titolo autorizzato: Evolutionary biology, cell-cell communication, and complex disease
• ISBN: 1-280-58655-9; 9786613616388; 1-118-13044-8; 1-118-13045-6; 1-118-13042-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910141320603321
• Lo trovi qui: Univ. Federico II