Advances in understanding genetic changes in cancer : impact on diagnosis and treatment decisions in the 1990s : a research briefing from the Division of Health Sciences Policy, Institute of Medicine

• Pubblicazione: Washington, D.C., : National Academy Press, 1992
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (96 p.)
• Disciplina: 616.99
• Soggetto topico: Cancer - Genetic aspects; Cancer - Research - United States
• Note generali: Bibliographic Level Mode of Issuance: Monograph
• Nota di bibliografia: Includes bibliographical references (p. 69-84).
• Nota di contenuto: ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER -- Copyright -- Statement of Purpose -- Contents -- ADVANCES IN UNDERSTANDING GENETIC CHANGES IN CANCER -- 1 Introduction -- OUTLINE OF MOLECULAR GENETICS -- BRIEF OVERVIEW OF CANCER GENETICS -- 2 Testing for Tumor-Specific Genetic Markers -- MICROSCOPIC DETECTION OF ALTERATIONS IN DNA STRUCTURE -- In Situ Hybridization -- Ploidy Analysis -- TECHNIQUES FOR DETECTING CHANGES IN DNA STRUCTURE AT THE SUBMICROSCOPIC LEVEL -- Southern Blot Hybridization -- Pulsed-Field Gel Electrophoresis -- Polymerase Chain Reaction -- TECHNIQUES FOR DETECTION OF POINT MUTATIONS IN DNA -- TECHNIQUES DIRECTED AT ANALYSIS OF RNA -- TECHNIQUES FOR ANALYZING CHANGES AT THE PROTEIN LEVEL -- Immunohistochemistry -- 3 Hematologic Cancer -- CHRONIC MYELOGENOUS LEUKEMIA -- CHRONIC LYMPHOCYTIC LEUKEMIA -- ACUTE LYMPHOCYTIC LEUKEMIA -- ACUTE MYELOGENOUS LEUKEMIA -- MYELODYSPLASTIC SYNDROMES -- LYMPHOMA -- 4 Solid Tumors -- CHROMOSOMAL ABERRATIONS OF DIAGNOSTIC IMPORTANCE -- CHROMOSOMAL ABERRATIONS OF PROGNOSTIC IMPORTANCE -- Neuroblastoma -- Breast Cancer -- Lung Cancer -- Other Solid Tumors -- GENETIC MARKERS OF PREDISPOSITION TO CANCER -- Retinoblastoma -- Mapping of Other Cancer Predisposition Loci -- Li-Fraumeni Syndrome -- Loss of Heterozygosity in Sporadic Solid Tumors -- GENETIC CHANGES AND TUMOR PROGRESSION -- Colorectal Neoplasms -- Glial Tumors -- CANCER-ASSOCIATED GENETIC CHANGES AND ENVIRONMENTAL MUTAGENS -- VIRAL MARKERS IN CANCER DIAGNOSIS -- 5 Summary and Specific Recommendations -- PRACTICAL ASPECTS OF GENETIC ANALYSIS: FROM PATIENT TO DIAGNOSTIC LABORATORY -- THE MOLECULAR DIAGNOSTIC LABORATORY -- IMPLICATIONS OF COMMERCIALIZATION -- FUTURE NEEDS -- 6 References.
• Titolo autorizzato: Advances in understanding genetic changes in cancer
• ISBN: 1-280-20304-8; 9786610203048; 0-309-57260-6; 0-585-08536-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910825995603321
• Lo trovi qui: Univ. Federico II