Chemical engineering in the pharmaceutical industry : R&D to manufacturing / / edited by David J. am Ende

• Pubblicazione: Hoboken, New Jersey : , : Wiley, , 2011; ©2011
• Descrizione fisica: 1 online resource (905 p.)
• Disciplina: 615.19; 615/.19
• Soggetto topico: Pharmaceutical technology; Biochemical engineering; Chemical engineering
• Persona (resp. second.): EndeDavid J. am
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: CHEMICAL ENGINEERING IN THE PHARMACEUTICAL INDUSTRY: R&D to Manufacturing; CONTENTS; PREFACE; CONTRIBUTORS; CONVERSION TABLE; PART I: INTRODUCTION; 1 CHEMICAL ENGINEERING IN THE PHARMACEUTICAL INDUSTRY: AN INTRODUCTION; 2 CURRENT CHALLENGES AND OPPORTUNITIES IN THE PHARMACEUTICAL INDUSTRY; 3 CHEMICAL ENGINEERING PRINCIPLES IN BIOLOGICS: UNIQUE CHALLENGES AND APPLICATIONS; 4 DESIGNING A SUSTAINABLE PHARMACEUTICAL INDUSTRY: THE ROLE OF CHEMICAL ENGINEERS; 5 SCIENTIFIC OPPORTUNITIES THROUGH QUALITY BY DESIGN; PART II: ACTIVE PHARMACEUTICAL INGREDIENT (API) ; 6 THE ROLE OF CHEMICAL ENGINEERING IN PHARMACEUTICAL API PROCESS R&D7 REACTION KINETICS AND CHARACTERIZATION; 8 UNDERSTANDING RATE PROCESSES IN CATALYTIC HYDROGENATION REACTIONS; 9 CHARACTERIZATION AND FIRST PRINCIPLES PREDICTION OF API REACTION SYSTEMS; 10 MODELING, OPTIMIZATION, AND APPLICATIONS OF KINETIC MECHANISMS WITH OPENCHEM; 11 PROCESS SAFETY AND REACTION HAZARD ASSESSMENT; 12 DESIGN OF DISTILLATION AND EXTRACTION OPERATIONS; 13 CRYSTALLIZATION DESIGN AND SCALE-UP; 14 SCALE-UP OF MIXING PROCESSES: A PRIMER; 15 STIRRED VESSELS: COMPUTATIONAL MODELING OF MULTIPHASE FLOWS AND MIXING ; 16 MEMBRANE SYSTEMS FOR PHARMACEUTICAL APPLICATIONS17 DESIGN OF FILTRATION AND DRYING OPERATIONS; 18 THE DESIGN AND ECONOMICS OF LARGE-SCALE CHROMATOGRAPHIC SEPARATIONS; 19 MILLING OPERATIONS IN THE PHARMACEUTICAL INDUSTRY; 20 PROCESS SCALE-UP AND ASSESSMENT; 21 SCALE-UP DOS AND DON'TS; 22 KILO LAB AND PILOT PLANT MANUFACTURING; 23 PROCESS DEVELOPMENT AND CASE STUDIES OF CONTINUOUS REACTOR SYSTEMS FOR PRODUCTION OF API AND PHARMACEUTICAL INTERMEDIATES; 24 DRUG SOLUBILITY AND REACTION THERMODYNAMICS; 25 THERMODYNAMICS AND RELATIVE SOLUBILITY PREDICTION OF POLYMORPHIC SYSTEMS ; 26 TOWARD A RATIONAL SOLVENT SELECTION FOR CONFORMATIONAL POLYMORPH SCREENING27 MOLECULAR THERMODYNAMICS FOR PHARMACEUTICAL PROCESS MODELING AND SIMULATION; 28 THE ROLE OF SIMULATION AND SCHEDULING TOOLS IN THE DEVELOPMENT AND MANUFACTURING OF ACTIVE PHARMACEUTICAL INGREDIENTS; PART III: ANALYTICAL METHODS AND APPLIED STATISTICS; 29 QUALITY BY DESIGN FOR ANALYTICAL METHODS; 30 ANALYTICAL CHEMISTRY FOR API PROCESS ENGINEERING; 31 QUANTITATIVE APPLICATIONS OF NMR SPECTROSCOPY; 32 EXPERIMENTAL DESIGN FOR PHARMACEUTICAL DEVELOPMENT; 33 MULTIVARIATE ANALYSIS FOR PHARMACEUTICAL DEVELOPMENT ; PART IV: DRUG PRODUCTS34 PROCESS MODELING TECHNIQUES AND APPLICATIONS FOR SOLID ORAL DRUG PRODUCTS; 35 PROCESS DESIGN AND DEVELOPMENT FOR NOVEL PHARMACEUTICAL DOSAGE FORMS; 36 DESIGN OF SOLID DOSAGE FORMULATIONS; 37 CONTROLLED RELEASE TECHNOLOGY AND DESIGN OF ORAL CONTROLLED RELEASE DOSAGE FORMS; 38 DESIGN AND SCALE-UP OF DRY GRANULATION PROCESSES; 39 WET GRANULATION PROCESSES; 40 SPRAY ATOMIZATION MODELING FOR TABLET FILM COATING PROCESSES; 41 THE FREEZE-DRYING PROCESS: THE USE OF MATHEMATICAL MODELING IN PROCESS DESIGN, UNDERSTANDING, AND SCALE-UP ; 42 ACHIEVING A HOT MELT EXTRUSION DESIGN SPACE FOR THE PRODUCTION OF SOLID SOLUTIONS
• Sommario/riassunto: This book deals with various unique elements in the drug development process within chemical engineering science and pharmaceutical R&D. The book is intended to be used as a professional reference and potentially as a text book reference in pharmaceutical engineering and pharmaceutical sciences. Many of the experimental methods related to pharmaceutical process development are learned on the job. This book is intended to provide many of those important concepts that R&D Engineers and manufacturing Engineers should know and be familiar if they are going to be successful in the Pharmaceutical In
• Titolo autorizzato: Chemical engineering in the pharmaceutical industry
• ISBN: 1-5231-4387-8; 1-118-08810-7; 1-283-37261-4; 9786613372611; 0-470-88222-0; 0-470-88221-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910140880003321
• Lo trovi qui: Univ. Federico II