The nature and origin of amyloid fibrils [[electronic resource] /] / [editors, Gregory R. Bock (Organizer) and Jamie A. Goode]

• Pubblicazione: Chichester ; ; New York, : Wiley, 1996
• Descrizione fisica: 1 online resource (268 p.)
• Disciplina: 612.015782; 612.8; 612.8042
• Soggetto topico: Amyloid; Amyloid beta-protein; Amyloidosis
• Altri autori: BockeGregory GoodeJamie
• Note generali: "Symposium on The nature and origin of amyloid fibrils, held at the Palácio dos Marqueses de Pombal, Oeiras, Portugal, 23-25 October 1995"--Contents.
• Nota di bibliografia: Includes bibliographical references and indexes.
• Nota di contenuto: THE NATURE AND ORIGIN OF AMYLOID FIBRILS; Contents; Participants; Preface; Introduction; In memoriam; A molecular model of the amyloid fibril; Refined fibril structures: the hydrophobic core in Alzheimer's amyloid b-protein and prion as revealed by X-ray diffraction; General discussion I; Modulating conformational factors in transthyretin amyloid; Proteoglycans and amyloid fibrillogenesis; Molecular mechanisms of fibrillogenesis and the protective role of amyloid P component: two possible avenues for therapy; General discussion II; Metabolism of amyloid proteins ; Alzheimer's disease: genesis of amyloidApolipoprotein E and amyloidogenesis; Interaction of transthyretin with amyloid B-protein: binding and inhibition of amyloid formation; General discussion III; B-amyloid precursor protein and early-o nset Alzheimer's disease; Prion protein amyloid: separation of scrapie infectivity from PrP polymers; General discussion IV; Ageing and amyloid fibrillogenesis: lessons from apolipoprotein Al, transthyretin and islet amyloid polypeptide; General discussion V ; FAP mutations destabilize transthyretin facilitating conformational changes required for amyloid formationIndex of contributors; Subject index
• Sommario/riassunto: Amyloid fibrils are associated with a range of pathological disorders including Alzheimer's Disease, Down's syndrome, diabetes, cardiomyopathies, and transmissible spongiform encephalopathies. This volume is a comprehensive account of recent developments in the understanding of the process of amyloid fibrils. Contains up-to-date data on all of the clinical problems which, despite their pathological significance, are still largely unsolved.
• Titolo autorizzato: The nature and origin of amyloid fibrils
• ISBN: 1-282-34797-7; 9786612347979; 0-470-51492-2; 0-470-51493-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830473703321
• Lo trovi qui: Univ. Federico II
• Serie: Ciba Foundation symposium ; ; 199.