Neurodegeneration : metallostasis and proteostasis / / edited by Danilo Milardi and Enrico Rizzarelli
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| Titolo: |
Neurodegeneration : metallostasis and proteostasis / / edited by Danilo Milardi and Enrico Rizzarelli
|
| Pubblicazione: | Cambridge, : RSC Pub., 2011 |
| Edizione: | 1st ed. |
| Descrizione fisica: | 1 online resource (285 p.) |
| Disciplina: | 616.8047 |
| Soggetto topico: | Nervous system - Degeneration |
| Altri autori: |
MilardiDanilo
RizzarelliEnrico
|
| Note generali: | Description based upon print version of record. |
| Nota di bibliografia: | Includes bibliographical references and index. |
| Nota di contenuto: | i-iv; v-viii; xi-xiv; 1-17.PDF.pdf; 18-45; 46-68; 69-82; 83-111; 112-140; 141-151; 152-173; 174-211; 212-225; 226-248; 249-258; 259-270 |
| Sommario/riassunto: | Since Alois Alzheimer described the results of his postmortem studies in 1906, significant strides have been made in understanding the pathogenesis of neurodegenerative diseases. Substantial evidence has accumulated indicating that diverse neurodegenerative disorders might share a common pathological mechanism: the misfolding, aggregation and accumulation of proteins (termed ""amyloid"") in the brain. Metal ions have long been thought to catalyze protein misfolding initiating a cascade of events resulting in oxidative damage and neurodegeneration. They have, consequently, been seen as a suitab |
| Titolo autorizzato: | Neurodegeneration |
| ISBN: | 1-84973-301-5 |
| Formato: | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione: | Inglese |
| Record Nr.: | 9910820104403321 |
| Lo trovi qui: | Univ. Federico II |
| Opac: | Controlla la disponibilità qui |
Serie:
RSC drug discovery series ; ; 7.