Advances in medicine and biology [[electronic resource] ] . Volume 20 / / Leon V. Berhardt, editor

• Pubblicazione: New York, : Nova Science Publishers, Inc., 2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (377 p.)
• Disciplina: 616
• Soggetto topico: Medicine - Research; Biology
• Altri autori: BerhardtLeon V
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- ADVANCES IN MEDICINE AND BIOLOGY. VOLUME 20 -- ADVANCES IN MEDICINE AND BIOLOGY. VOLUME 20 -- CONTENTS -- PREFACE -- TROPONIN T: A SEARCH OF SUPERPARAMAGNETIC IRON-OXIDE BOUND ANTITROPONIN NANOPARTICLE FOR MAGNETIC RESONANCE IMAGING -- Abstract -- Introduction -- 2. Materials and Methods -- 2.1. Preparation and Characterization of Nonoparticle Complex -- 2.2. Gadolinium Enhanced T1 Weighted Imaging of Apoferritin-Gadolinium Complex -- 2.3. Characterization of Cardiac Troponin T/I/C Subtypes and MALDI Imaging -- 2.4. Development of Antitroponin Based Nanoparticles as MRI Imaging Contrast Agents -- Selection of TE and TR for Optimizing Contrast -- 2.5. MRI Microimaging of Heart and Prototype Tube -- 2.6. Characterization, Detection of and Measurement of Cardiac Muscle Components -- 3. Results -- 3.1. The Polymer Coated Superparamagnetic Biotinylated Antitroponint Microspheres as Image Contrast -- 3.2. Gadolinium Enhanced T1 Weighted Imaging of Apoferritin-Gadolinium Complex -- 3.3. Characterization of Cardiac Troponin T/I/C Subtypes and MALDI Imaging -- 3.4. High Resolution Magnetic Resonance Imaging of Nanoparticles and Post-Injected Mouse Heart -- 3.5. Characterization, Detection of and Measurement of Cardiac Muscle Components -- 4. Discussion -- 5. Limitations and Challenges of the Study -- 6. The Futuristic View of Art -- 7. Conclusion -- Acknowledgments -- References -- TROPONIN T: NEWER MAGNETIC IMMUNOASSAY METHOD OF TROPONINS AS POINT-OF-CARE DETECTION OF ACUTE MYOCARDIAL INFARCTION -- Abstract -- 1. Introduction -- 1.2. Synthesis of Nanomagnetic Particles for Biomedical Applications -- 1.3. Characterization of Antitroponin Based Nanoparticle Complex by Sandwich ELISA -- 1.4. Principle of Nanoparticle in Magnetic Assay -- 2. AMI Detectable Device -- 2.1. The POCM Device. ; 2.2. Device for Acute Myocardial Infarction Detection and Troponin Screening -- 2.3. Principle of Dry Chemistry Glucodetection in Troponin Estimation -- 2.4. Calibration of Glucose Measurement -- 2.2. The Use of the Fluorescent Dry Chemistry in Glucodetection Device -- 3. Detection of Troponin T as Point-of-Care AMI Test -- 4. Approach of Troponin MALDI Analysis -- 5. MALDI-TOF Analysis in AMI Serum -- 6. Limitations -- Conclusion -- Acknowledgments -- References -- GENOTOXICITY EVALUATION OF EXPOSURE TO LEAD -- ABSTRACT -- 1. INTRODUCTION -- 1.1. Lead Modes of Action -- Interaction with Sulphydryl Groups of Proteins -- Supplanting of Essential Polyvalent Cations -- Free Radical Production -- 1.2. Genotoxicity Tests -- 2. HYPOXANTHINE-GUANINE PHOSPHORIBOSYL- TRANSFERASE GENE MUTATION ASSAY -- 3. T CELL RECEPTOR MUTATION ASSAY -- 4. CHROMOSOME ABERRATIONS -- 4.1. In Vitro Studies -- 4.2. In Vivo Studies -- 4.3. Epidemiological Studies -- 5. SISTER CHROMATID EXCHANGES -- 5.1. In Vitro Studies -- 5.2. In Vivo Studies -- 5.3. Epidemiological Studies -- 6. MICRONUCLEUS TEST -- 6.1. In Vitro Studies -- 6.2. In Vivo Studies -- 6.3. Epidemiological Studies -- 7. SINGLE CELL GEL ELECTROPHORESIS (COMET) ASSAY -- 7.1. In Vitro Studies -- 7.2. In Vivo Studies -- 7.3. Epidemiological Studies -- CONCLUDING REMARKS -- ACKNOWLEDGMENTS -- REFERENCES -- CELL CYCLE ALTERATION IN DOWN SYNDROME -- ABSTRACT -- INTRODUCTION -- CELL CYCLE AND NEUROGENESIS ALTERATIONS IN DOWN SYNDROME -- CONTRIBUTION OF CHROMOSOME 21 GENES IN TUMORS AND CANCERS -- Single Minded Gene (SIM2) -- T-Cell Lymphoma Invasion and Metastasis 1 Gene, TIAM1 -- CONTRIBUTION OF CHROMOSOME 21 GENES IN LEUKEMIA -- Cooperation of Chromosome 21 Genes with GATA1 During Leukemogenesis -- Acute Myeloid Leukaemia Gene, AML1 -- ETS Transcription Factors ETS2 and ERG. ; Basic Leucine Zipper Transcription Factor 1, BACH1 -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- ALTERATIONS OF AUTONOMIC MODULATION OF HEART RATE VARIABILITY IN EATING DISORDERS -- ABSTRACT -- INTRODUCTION -- HRV ANALYSIS: METHODOLOGICAL AND GENERAL ASPECTS -- Heart Rate Variability in Eating Disorders -- ENDOCRINE CHANGES AND HRV IN EATING DISORDERS: A PERSPECTIVE FOR FUTURE INVESTIGATIONS -- CONCLUSIONS -- REFERENCES -- ANTIMICROBIAL-RESISTANT GRAM-POSITIVE COCCI IN THE THIRD MILLENNIUM: NOVEL PHARMACEUTICAL WEAPONS AND THEIR THERAPEUTIC PERSPECTIVES -- ABSTRACT -- EPIDEMIOLOGICAL EXPERIENCE AT A MAJOR TERTIARY CARE HOSPITAL IN NORTHERN ITALY -- NOVEL ANTIBACTERIAL AGENTS WITH ENHANCED ACTIVITY AGAINST RESISTANT GRAM POSITIVE COCCI -- Quinupristin/Dalfopristin -- Linezolid -- Daptomycin -- Tigecycline -- Dalbavancin -- Oritavancin -- Telavancin -- CLINICAL INDICATIONS OF NOVEL ANTIBIOTICS WITH EXPANDED SPECTRUM AGAINST RESISTANT GRAM-POSITIVE COCCI -- Skin and Soft-Tissue Infections -- Bone and Joint Infections -- Pneumonia and Lower Respiratory Tract Infections -- Intra-abdominal Infections -- Bacteremia and Endocarditis -- POTENTIAL SYNERGISTIC INTERACTIONS OF NEWER ANTIBIOTICS: IN VITRO STUDIES -- REFERENCES -- PROMISING APPLICATIONS FOR TLR AGONISTS AS IMMUNE ADJUVANTS -- ABSTRACT -- Untitled -- STRUCTURE -- Signaling: TLR Activation -- MyD88-Dependent Pathway -- MyD88-Independent (TRIF-Dependent) Pathway -- TLR Agonists as Adjuvants -- How Do TLR Agonists Stimulate Adaptive Immunity? -- Cross-Priming of CD8 T Cells -- IL-12 and Th1 Responses -- Reversal of Tolerance -- Upregulation of Co-Stimulatory Molecules -- TLR AGONISTS WITH POTENTIAL CLINICAL USE -- TLR2 -- TLR4 -- TLR5 -- TLR7/8 -- TLR9 -- CONCLUSION -- REFERENCES -- CURRENT TRENDS IN GLAUCOMA: WHAT'S ABOUT NEUROPROTECTION? -- ABSTRACT -- INTRODUCTION. ; 1. Epidemiology And Risk Factors In Glaucoma -- 2. Biphasic Theory For Glaucoma Damage -- 2.1. Mechanical and vascular factors trigger glaucoma pathogenesis -- 2.2. Secondary degeneration -- a) Molecular changes -- Neurotrophin deprivation -- Activation of the caspase enzyme family -- Glutamate induced excitotoxicity -- ATP releases -- TNF-α -- Oxidative stress and free radicals -- Increased accumulation of self-proteins -- Increased expression of pro-apoptotic genes -- b) Cellular changes -- "Activation" response of glial cells -- Muller cell gliosis -- Astrocyte induced vasoconstriction -- 3.Glaucoma And Neuroprotection -- 3.1. Neuroprotective Drugs In Glaucoma -- 3.1.1.Ocular hypotensive drugs -- a). Antiglaucomatous agents -- b). Cannabinoids -- 3.2. Other drugs -- a). Tetracyclines -- Minocycline -- Doxycycline -- b). Ca 2+ channel blockers -- Nifedipine -- Flunarizine -- c). Antioxidants -- d) NMDA antagonists, p38 MAPK, and caspase inhibitors -- e). 17beta-estradiol -- f). Nitric oxide synthase (NOS-2) inhibitors (Aminoguanidine) -- g). Erythropoietin -- 4. Future Neuroprotective Therapies For Glaucoma -- 4.1. Neurotrophins -- 4.2. Controlling Infamation: Anti-TNF-α-Strategies -- 4.3 Inmunomodulatory Compounds: Glatiramer Acetate(GA) -- 4.4 Gene Therapy -- 4.5 siRNA -- 4.6 Stem Cells -- ACKNOWLEDGMENTS -- REFERENCES -- PHARMACOLOGICAL ASPECTS OF BORATES -- ABSTRACT -- 1. INTRODUCTION -- 2. CLINICAL USES -- 2.1. Antibacterial Agent -- 2.2. Antifungal Agent -- 2.3. Chemopreventive Agent for Human Cancer -- 2.4. Wound Treatment -- 2.5. Ear Infections -- 2.6. Dental Treatment -- 3. TOXICITY -- 3.1. Human Toxicity -- 3.2. Embryotoxicity -- 3.3. Developmental and Reproductive Toxicity -- 3.4. Genotoxicity -- 3.5. Phytotoxicity -- 4. ABSORPTION OF BORIC ACID -- 5. DISSOLUTION KINETICS -- 6. PHARMACOKINETICS OF BORIC ACID -- 8. OXIDATIVE STRESS. ; 9. ENZYME INHIBITION -- 10. SYNTHESIS OF BIOACTIVE COMPOUNDS -- 11. ANALYSIS IN BIOLOGICAL FLUIDS -- 12. PRESERVATION AND INSECT CONTROL -- 12.1. Preservative -- 12.2. Insecticide -- REFERENCES -- PHAGE DISPLAY TECHNOLOGY: NEW BIOTECHNOLOGICAL APPLICATIONS IN SYNTHETIC BIOLOGY -- ABSTRACT -- INTRODUCTION -- SYNTHETIC BIOLOGY AND THE "NEVER BORN PROTEINS" -- PROTEIN ENGINEERING AND DIRECTED EVOLUTION -- IN VITRO AND BIOLOGICAL DISPLAY TECHNOLOGIES -- PHAGE DISPLAY FOR DIRECTED MOLECULAR EVOLUTION -- ANTIBODY PHAGE -- PHAGE AS PROBES IN NANOBIOTECHNOLOGY -- VIRUSES AS NEW MATERIALS -- PHAGE PERSPECTIVES IN SYNTHETIC BIOLOGY -- CONCLUSION -- REFERENCES -- ANALYTICAL METHODS FOR THE QUANTITATIVE DETERMINATION OF OXYTOCIN -- ABSTRACT -- INTRODUCTION -- BIOASSAY -- PARTITION AND THIN LAYER CHROMATOGRAPHY -- ELECTROPHORETIC SEPARATIONS -- REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY -- UV DETECTION -- FLUORESCENCE METHODS WITH DERIVATIZATION -- PHOTODIODE ARRAY DETECTION -- COULOMETRIC DETERMINATION -- LC MS METHODS -- CATION EXCHANGE CHROMATOGRAPHY -- RADIO-IMMUNOASSAY -- ENZYME-LINKED IMMUNO-SORBENT ASSAY -- CONCLUSION -- REFERENCES -- PLANT CELL WALL FUNCTIONAL GENOMICS: NOVELTIES FROM PROTEOMICS -- ABSTRACT -- INTRODUCTION -- IS PROTEOMICS REDUNDANT WITH REGARD TO TRANSCRIPTOMICS? -- A SUMMARY OF PRESENT PROTEOMIC RESULTS OBTAINED ON ARABIDOPSIS THALIANA -- WHY INVESTIGATING ADDITIONAL CELL WALL PROTEOMES? -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- ISOLATED RAT HEARTS PRESERVED FOR 24-120 HOURS IN THE PRESENCE OF ARBON MONOXIDE AND CARBON DIOXIDE, RESUSCITATION AND HETEROTOPIC TRANSPLANTATION -- ABSTRACT -- INTRODUCTION -- SECTION 1: DESICCATION AND PRESERVATION WITH CARBON DIOXIDE -- SECTION 2: DESICCATION AND PRESERVATION WITH CARBON MONOXIDE. ; SECTION 3: DESICCATION AND PRESERVATION WITH CARBON MONOXIDE, CARBON DIOXIDE, HELIUM AND OXYGEN.
• Titolo autorizzato: Advances in medicine and biology
• ISBN: 1-62100-056-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910810595103321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Medicine and Biology