Estrogen effects on traumatic brain injury : mechanisms of neuroprotection and repair / / edited by Kelli Duncan ; contributors Marco Avila-Rodriguez [and twenty eight others]

• Pubblicazione: London, England : , : Academic Press, , 2015; ©2015
• Descrizione fisica: 1 online resource (172 p.)
• Disciplina: 618.175061
• Soggetto topico: Estrogen - Therapeutic use
• Persona (resp. second.): DuncanKelli; Avila-RodriguezMarco
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Front Cover; Estrogen Effects on Traumatic Brain Injury; Copyright Page; Contents; About the Editor; List of Contributors; About the Contributors; Taura Barr; George E. Barreto; Suzanne R. Burstein; Francisco Capani; Laura L. Carruth; Nicolas Diotel; Miranda Reed; Colin J. Saldanha; James Simpkins; Farida Sohrabji; Introduction; Why Should I Care?; Rationale and Scope of the Book; 1 Historical Antecedents; Introduction; The "INS AND OUTS" of TBI: An Overview; A History of TBI from Antiquity Through the 19th Century; From the Bench to the Clinic: TBI in the 20th and 21st Century ; Conclusions and Future ThoughtsAcknowledgements; References; 2 Estrogen Actions in the Brain; Introduction; Steroid Hormones; Estrogens; Estrogen Receptors; Blood-Brain Barrier and Glial Cells; Estradiol and Brain Sexual Differentiation; Rapid Estrogen Signaling in the Brain; Estrogen-Sensitive Brain Regions; Sexually Dimorphic Brain Regions; Hippocampus; Cerebellum; Neurotransmitter Systems; Basal Forebrain Cholinergic System; Midbrain and Brainstem Serotonergic System; Catecholaminergic Neurons; Estrogens, Aging, and Neuroprotection; Additional Physiological Effects of Estrogens on the Body ; Conclusions and New DirectionsReferences; 3 Induction of Estrogen Response Following Injury; Introduction; Reactive Gliosis Following Injury; New Roles for Glial Cells as Steroid Synthesizing Cells; Induction of Glial Aromatase Following Injury; Neuroinflammation Induces Glial Aromatase Independent of Injury; Sex Differences in Cytokine Response Following Injury; Sex Differences in Glial Aromatase Expression Following Injury; Conclusion and Future Directions; Acknowledgements; References; 4 Astrocytic Aromatization and Injury; Aromatase is Expressed in Astroglia ; What Induces Astrocytic Aromatase Expression?Glial Estrogen Synthesis and Neuroprotection; Apoptosis and Secondary Degeneration; Injury-Induced Cyto- and Neurogenesis; Summary and Future Directions; Further Reading; 5 Aromatase and Estrogens: Involvement in Constitutive and Regenerative Neurogenesis in Adult Zebrafish; Introduction; Unique Features Exhibited by the Brain of Teleost Fish; Neurosteroid Synthesis and Signaling in the Brain of Adult Zebrafish; Aromatase B Expression is Restricted to Radial Glia Acting Like Neural Stem Cells ; Involvement of Aromatase and Estrogens in Adult Neurogenesis and Brain Repair in ZebrafishComparison with Mammalian and Nonmammalian Models; Hypothesis and Perspectives for Estrogen Involvement in Neurogenesis Regarding New Advances in Zebrafish and New Literature...; Conclusion; References; 6 Neuroprotection by Exogenous Estrogenic Compounds Following Traumatic Brain Injury; Introduction; Neuroprotective Steroids; Estrogens, Progestagens and Androgens as Protective Compounds; Selective Estrogen Receptor Modulators; Selective Tissue Estrogenic Activity Regulator; TBI Protection Strategies ; Role of Neuroactive Steroids in TBI
• Sommario/riassunto: This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain In
• Titolo autorizzato: Estrogen effects on traumatic brain injury
• ISBN: 0-12-801707-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910807641103321
• Lo trovi qui: Univ. Federico II