Biomarkers in diabetes / / edited by Vinood B. Patel and Victor R. Preedy

• Pubblicazione: Cham, Switzerland : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (1162 pages)
• Disciplina: 610.28
• Soggetto topico: Biochemical markers; Diabetes - Diagnosis
• Persona (resp. second.): PatelVinood B.; PreedyVictor R.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Preface -- Contents -- About the Editors -- Contributors -- Part I: General Aspects -- 1 Linking Variants of Hemoglobin A1C and Glycemic Status -- Introduction -- Overview of Genome-Wide Association Studies of HbA1c -- Functional Characterization of HbA1c-Associated Genetic Variants -- Glycemic-Related Genetic Variants -- Erythrocyte-Related Genetic Variants -- Unclassified Genetic Variants -- Erythrocyte-Related HbA1c Variants and Glycemic Status Screening -- G6PD: rs1050828 and rs76723693 -- HBB-rs334 -- G6PD-rs1050828 and HBB-rs334 -- Cumulative Effect of Erythrocyte-Related Genetic Variants -- Conclusion -- Applications to Other Diseases or Conditions -- Mini-Dictionary of Terms -- Key Facts of HbA1c -- Summary Points -- Reference -- 2 Treatment Regimes in Diabetes and Their Impact on Biomarkers -- Lipid Profile and T2DM -- Introduction to Lipids and T2DM -- The Relationship Between Obesity and Lipids -- The Relationship Between Lipids and T2DM -- Lipid Intermediates and Insulin Resistance -- Role of Exercise on Lipid Metabolism in T2DM -- Acute Effects of Exercise on Muscle Lipid Content -- Acute Effects of Exercise on Muscle Lipid Intermediates -- Chronic Effects of Exercise on Muscle Lipid Content -- Chronic Effects of Exercise on Muscle Lipid Intermediates -- Effect of Exercise on Liver Lipid Content -- Exercise Interventions and Classic Lipid Biomarkers -- Inflammatory Profile and T2DM -- Introduction to Inflammation and T2DM -- The Relationship Between Obesity and Inflammation -- The Relationship Between Inflammation and T2DM -- TNF-α and T2DM -- IL-6 and T2DM -- IL-1β and T2DM -- Anti-inflammatory Effects of Exercise -- Acute Effects of Exercise and Anti-inflammatory Mechanisms -- Chronic Effects of Exercise and Anti-inflammatory Mechanisms -- Exercise Interventions and Inflammatory Biomarkers. ; Applications to Other Diseases or Conditions -- Conclusion -- Mini-Dictionary of Terms -- Key Facts on Exercise and the Lipid Profile -- Key Facts on Exercise and Inflammation -- Summary Points -- References -- Part II: Circulating and Body Fluid Biomarkers: Impact of Diabetes on Pathology -- 3 Resistin as a Biomarker and Applications to Prediabetes -- Introduction -- Diabetes -- Prediabetes: Definition and Related Diseases -- The Role of Adipokines at Energy Balance -- Resistin As a Biomarker at Different Types of Disease -- Resistin As a Biomarker in Cardiovascular Disorders -- Resistin As a Biomarker in Obesity -- Resistin As a Biomarker in Diabetes -- Resistin As a Biomarker in Cancer -- The Association Between Resistin and Prediabetes and Outcomes -- Conclusion -- Key Facts of Resistin -- Summary Points -- References -- 4 Altered Metabolome of Amino Acids Species: A Source of Signature Early Biomarkers of T2DM -- Introduction -- Diabetes Mellitus -- The Need for New Biomarkers for Diabetes -- Amino Acids in Metabolic Signaling and Insulin Resistance -- Altered Amino Acid Profiles in Insulin Resistance and Diabetes -- Amino Acids Metabolic Intermediates As Markers for Insulin Resistance and Diabetes -- Conclusions -- Applications to Prognosis, Other Diseases, or Conditions -- Mini Dictionary of Terms -- Key Facts of Amino acids -- Summary Points -- References -- 5 Components of the Purine Metabolism Pathways as Biomarkers for the Early Diagnosis of Diabetes -- Introduction -- Purine Metabolism -- Xanthine Oxidase -- Adenosine Metabolizing Enzymes, Inosine and Adenosine -- Inosine-5′-Monophosphate Dehydrogenase -- Uric Acid -- Conclusion -- Applications to Prognosis, Other Diseases or Conditions -- Mini-Dictionary of Terms -- Key Facts of Purine Enzymes and Related Metabolites -- Summary Points -- References. ; 6 Serpin A12 (Vaspin) as a Serine Protease Inhibitor -- Introduction -- Type 2 Diabetes and the Importance of Biomarkers -- Vaspin as a Diabetes Biomarker -- Biochemical Characterization -- Main Sources of Vaspin -- Vaspin and Anti-Inflammatory Effects -- Glucose Intolerance and Vaspin -- Insulin Role and Vaspin Action -- Circulating Vaspin Level, Type 2 Diabetes, and Obesity -- Metabolic Syndrome (MetS) and Vaspin -- Applications to Prognosis, Other Diseases, and Conditions -- Conclusion -- Mini-Dictionary of Terms -- Key Facts of Type 2 Diabetes -- Summary Points -- References -- 7 Advanced Glycation End Products in Diabetes -- Introduction -- Advanced Glycation End Products (AGEs) -- AGE Receptors -- Effects of AGEs -- AGE Measurements -- Effects of AGEs in Diabetes -- Nephropathy in Diabetes -- Cardiomyopathy and Arterial Alterations in Diabetes -- Neuropathy in Diabetes -- Retinopathy in Diabetes -- Cancer and Diabetes -- Cross Talk Between AGEs and Oxidative Stress in Diabetes -- AGEs in Other Diseases -- Applications to Other Diseases or Conditions -- Mini Dictionary of Terms -- Key Facts of Diabetes: Where Advanced Glycation End Products Is the Topic -- Summary Points -- References -- 8 Markers of Liver Function and Insulin Resistance -- Introduction -- Applications to Diagnosis -- Mini-Dictionary of Terms -- Summary Points (5-10) -- Markers of Liver Function and Insulin Resistance -- Visceral Fat and Insulin Resistance -- NAFLD, IR Y T2DM -- Hepatokines -- DPP4 (Dipeptidyl Peptidase-4) -- Pharmacological DPP-4 Inhibitors -- Fetuin A (AHSG) -- Fetuin B -- Selenoprotein P -- LECT-2 -- Hepassocin, Also Called Hepatocyte-Derived Fibrinogen-Related Protein 1, HPS, and HFREP1 -- Pigment Epithelium-Derived Factor -- Tsukushi (TSK) -- Conclusions -- References -- 9 Biological Markers of Insulin Sensitivity Links with Dietary Antioxidant. ; Introduction -- Applications to Diagnosis -- Mini Dictionary of Terms -- Key Facts of Insulin Sensitivity, Biomarkers, and Dietary Antioxidants -- Summary Points -- Markers of Liver Function and Insulin Resistance -- Insulin Sensitivity -- Adiponectin -- Adropin, Angiopoietin-lLike Protein 4 (ANGPTL4) -- DPP4, GLP-1 -- Fetuin-A and Fetuin-B -- FGF21 -- HMBG1, Myostatin -- Interleukins, Irisin, RBP4 -- Minerals in Insulin Resistance Sensitivity -- Calcium, Magnesium -- Chromiun, Selenium, Zinc -- Vitamins in Insulin Sensitivity -- Vitamin C, E -- Vitamin D, K, B -- Conclusions -- References -- 10 Serum Uric Acid and Metabolic Markers in Diabetes -- Introduction -- Metabolic Markers in Diabetes -- Uric Acid -- Uric Acid in Diabetes Pathophysiology -- Uric Acid as a Biomarker in Diabetes -- Serum Uric Acid as a Predictor of Diabetes Risk -- Serum Uric Acid, Blood Glucose Level, and HbA1c -- Uric Acid in Diabetic Complications -- Uric Acid in Macrovascular Complications -- Uric Acid in Microvascular Complications -- eGFR and Serum Uric Acid Levels -- Applications to Prognosis and Other Diseases or Conditions -- Applications to Prognosis -- Applications to Other Diseases or Conditions -- Mini-Dictionary of Terms -- Key Facts of Serum Uric Acid and Metabolic Markers in Diabetes: eGFR, HbA1c, and Beyond -- Key Facts of Uric Acid and Diabetes -- Key Facts of Uric Acid and Diabetic Complications -- Summary Points -- References -- 11 Urinary Interleukins and Kidney Damage in Diabetes -- Introduction -- Inflammation and Diabetic Kidney Disease -- Urinary Interleukins -- Interleukin 1 -- Interleukin 6 -- Interleukin 8 -- Interleukin 10 -- Interleukin 18 -- Potential Applications to Prognosis, Other Diseases, or Conditions -- Mini-dictionary of Terms -- Key Facts of Diabetes, Kidney Damage, and Urinary Interleukins -- Summary Points -- References. ; 12 Serum Homocysteine as a Biomarker in Diabetes -- Introduction -- Homocysteine and Its Role in the Body -- Biosynthesis and Metabolism of Homocysteine -- Factors Causing Hyperhomocysteinemia -- Diabetes Mellitus Cellular Metabolism Disturbance and Micronutrient Status in Diabetes Mellitus -- Hyperhomocysteinemia and Diabetes Mellitus -- Cognitive Dysfunction in Diabetes Mellitus -- Cognitive Function -- Factors That Affect Cognitive Function -- Hyperhomocysteinemia and Cognitive Function -- Compliance in Diabetes Management and Cognitive Dysfunction -- Applications to Prognosis -- Mini-Dictionary of Terms -- Key Facts of Serum Homocysteine as a Biomarker in Diabetes: Links with Variables Such as Cognition -- Summary Points -- References -- 13 3-Hydroxyisobutyrate (3-HIB): Features and Links as a Biological Marker in Diabetes -- Introduction -- BCAA Catabolism in Adipose Tissue -- 3-HIB in Interorgan Metabolic Crosstalk -- 3-HIB Reflects Hepatic Fatty Acid Oxidation -- Conclusion and Future Perspectives -- Applications to Prognosis, Other Diseases, or Conditions -- Mini-Dictionary of Terms -- Key Facts of Diabetes -- Summary Points -- References -- 14 Proteomic Biomarkers: What They Are and How Type 2 Diabetes Mellitus Has Similarities with Other Diseases -- Introduction -- Proteomic Biomarkers and Type 2 Diabetes Mellitus -- Proteomics in Type 2 Diabetes Mellitus Complications -- Diabetic Retinopathy -- Diabetic Kidney Disease -- Diabetic Neuropathy and Chronic Wounds -- Proteomics in Type 2 Diabetes Mellitus and Other Diseases -- Type 2 Diabetes Mellitus and Obesity -- Type 2 Diabetes Mellitus and Cardiovascular Diseases -- Type 2 Diabetes Mellitus and Metabolic Diseases -- Type 2 Diabetes Mellitus and Pancreatic Cancer -- Type 2 Diabetes Mellitus and Neurologic Disorders -- Conclusion -- Applications to Prognosis and Other Diseases or Conditions. ; Applications to Prognosis.
• Titolo autorizzato: Biomarkers in Diabetes
• ISBN: 3-031-08014-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910616369603321
• Lo trovi qui: Univ. Federico II
• Serie: Biomarkers in Disease: Methods, Discoveries and Applications