Bioinspired and biomimetic polymer systems for drug, protein and gene delivery / / Zhongwei Gu

• Autore: Gu Zhongwei
• Pubblicazione: Weinheim, Germany : , : Wiley-VCH Verlag, , 2015; ©2015
• Descrizione fisica: 1 online resource (362 p.)
• Disciplina: 615.6
• Soggetto topico: Drug delivery systems
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Bioinspired and Biomimetic Polymer Systems for Drug and Gene Delivery; Contents; List of Contributors; Preface; Chapter 1 Backbone Degradable and Coiled-Coil Based Macromolecular Therapeutics; 1.1 Introduction; 1.2 Water-Soluble Polymers as Carriers of Anticancer Drugs; 1.2.1 First Generation Conjugates - Design, Synthesis, and Activity; 1.2.2 Analysis of Design Factors That Need Attention; 1.2.2.1 Design of Conjugates for the Treatment of Noncancerous Diseases; 1.2.2.2 Combination Therapy Using Polymer-Bound Therapeutics; 1.2.2.3 New Targeting Strategies ; 1.2.2.4 Relationship Between Detailed Structure of the Conjugates and Their Properties1.2.2.5 Impact of Binding a Drug to a Polymer on the Mechanism of Action; 1.2.2.6 Mechanism of Internalization and Subcellular Trafficking; 1.2.2.7 Relationship Between the Molecular Weight of the Carrier and the Efficacy of the Conjugate; 1.2.3 Design of Second Generation Conjugates - Long-Circulating and Backbone Degradable; 1.2.3.1 RAFT Copolymerization for the Synthesis of Conjugates; 1.2.3.2 Click Reactions for Chain Extension into Multiblock Copolymers ; 1.2.3.3 Biological Properties of Long-Circulating Macromolecular Therapeutics1.2.4 Summary of Part 2 and Future Prospects; 1.3 Drug-Free Macromolecular Therapeutics - A New Paradigm in Drug Delivery; 1.3.1 Biorecognition in Hybrid Polymer Systems; 1.3.2 Coiled-Coils in Biomedical Systems; 1.3.3 Coiled-Coil Based Drug-Free Macromolecular Therapeutics: Design, In Vitro, and In Vivo Activity; 1.3.4 Potential, Limitations, and Future Prospect of Drug-Free Macromolecular Therapeutics; 1.4 General Summary and Outlook; Acknowledgments; References ; Chapter 2 Dendritic Polymers as Targeting Nanoscale Drug Delivery Systems for Cancer Therapy2.1 Introduction; 2.2 Functional Dendritic Polymers Based Drug Delivery Vehicles for Targeting Tumor Therapy via EPR Effect; 2.2.1 Functional Dendritic Polymers for Encapsulation of Anticancer Drugs; 2.2.2 Chemical Conjugation Functional Dendritic Polymers as Drug Delivery Systems; 2.3 Tumor Targeting Moieties Functionalized Dendritic Drug Delivery Vehicles for Cancer Therapy; 2.4 Conclusion; References; Chapter 3 Composite Colloidal Nanosystems for Targeted Delivery and Sensing; 3.1 Introduction ; 3.1.1 Working Toolkit3.1.2 Engineering a Multifunctional Carrier; 3.2 Objective; 3.3 Cellular Behavior of the Carrier; 3.3.1 Intracellular Fate; 3.3.2 Biocompatibility; 3.4 Applications; 3.4.1 Delivery with Multifunctional PEM Capsules; 3.4.1.1 Magnetic Targeting and Magnetofection; 3.4.1.2 Strategies for Controlled Opening; 3.4.2 Intracellular Ion Sensing; 3.5 Conclusions; Abbreviations; References; Chapter 4 Polymeric Micelles for Cancer-Targeted Drug Delivery; 4.1 Introduction; 4.2 Micelle Formulations in Clinical Development; 4.3 Particle Size of Micelles; 4.4 Morphology of Micelles ; 4.5 Targeting Design of Micelles for Enhanced Accumulation and Cell Internalization
• Sommario/riassunto: Here, front-line researchers in the booming field of nanobiotechnology describe the most promising approaches for bioinspired drug delivery, encompassing small molecule delivery, delivery of therapeutic proteins and gene delivery. The carriers surveyed include polymeric, proteinaceous and lipid systems on the nanoscale, with a focus on their adaptability for different cargoes and target tissues.<br>Thanks to the broad coverage of carriers as well as cargoes discussed, every researcher in the field will find valuable information here.
• Titolo autorizzato: Bioinspired and biomimetic polymer systems for drug, protein and gene delivery
• ISBN: 3-527-67272-9; 3-527-67275-3; 3-527-67273-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910140484403321
• Lo trovi qui: Univ. Federico II