Neuroplasticity in the auditory brainstem : from physiology to the drug therapy / / Angelo Salami. editor

• Pubblicazione: New York, : Nova Science Publishers, c2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (191 p.)
• Disciplina: 612.8/5
• Soggetto topico: Auditory pathways; Neuroplasticity; Brain stem; Cochlear implants
• Altri autori: SalamiAngelo
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- NEUROPLASTICITY IN THE AUDITORY BRAINSTEM: FROM PHYSIOLOGY TO THE DRUG THERAPY -- NEUROPLASTICITY IN THE AUDITORY BRAINSTEM: FROM PHYSIOLOGY TO THE DRUG THERAPY -- Contents -- Introduction -- Chapter I Anatomy of the Auditory Pathway -- Abstract -- 1. The Inner Ear -- 2. The Auditory Nerve -- 3. The Central Auditory Pathway -- 3.1. The Cochlear Nuclear Complex (CNC) -- 3.2. Superior Olivary Complex (SOC) -- 3.3. Inferior Colliculus (IC) -- 4. Central Pathways and Cortical Projections -- 5. The Primary Auditory Cortex (PAC, AI) -- 6. Efferent Projections -- 6.1. From the AC to both the MBG and IC -- 6.2. From the IC to both Cochlear Nuclei (CN) and the SOC -- 6.3. From the SOC to the Hair Cells -- References -- Chapter II Phsyiology of the Central Auditory System -- Introduction -- Central Auditory Processing Strategies -- Spontaneous Rat -- Intensity Coding -- Frequency Coding -- Temporal Coding -- Sound Localization -- Complex Stimuli -- Variation in the Physiology of the Normal Central Auditory Pathway -- Anesthesia -- Development -- Attention -- Conclusions -- Acknowledgments -- References -- Chapter III Neurobiology of Age Related Hearing Loss -- Abstract -- Introduction -- Neurobiology -- Neurotrophins -- Mitochondrial Modifications -- Other Mechanisms of Mitochondrial Damage are Related to Lipid Oxidation and Protein Oxidation -- Discussion -- Conclusion -- References -- Chapter IV Neuroplasticity in the Auditory System after Hearing Loss -- Abstract -- Introduction -- Molecular Mechanisms of Neuroplasticity -- Neuroplasticity and Auditory System -- Neurons, Growth Cones and Neuroplasticity -- Neuroplasticity and Experimental Deafness by Cochlear Induced Lesion -- 1. First Phase: Acute Cochlear Nuclei Degeneration [5,6] -- 2. Second Phase: Stabilization of Lesions and Neuroplasticity. ; 3. Third Phase: Neuroplasticity and CN Reorganization -- Conclusion -- Acknowledgments -- References -- Chapter V Hearing Loss and Balance Dysfunction in Children -- Introduction -- Sensorineural Hearing Loss -- 1. Balance and Vestibular Dysfunction in SHNL -- 2. Cochlear Implantation and Vestibular Function -- Conductive Hearing Loss -- Rehabilitation of Balance and Motor Skills in the Hearing Impaired Child -- Conclusion -- References -- Chapter VI The Effect of Brain Plasticity on the Results of Cochlear Implantation -- Abstract -- 1. The Importance of Brain Research in Deaf Patients -- 2. Cross-Modal Plasticity -- 3. Method Used to Evaluate Human Brain Function -- 4. PET Studies in Deaf Patients -- 4.1. Cortical Metabolism in Prelingually Deaf Children -- 4.2. Cortical Metabolism in Postlingually Deaf Adults -- 4.3. The Association between Cortical Metabolism and Post-implant Speech Perception in the Prelingually Deaf -- 4.4. Changes in Cortical Metabolism after Cochlear Implantation -- 5. Changes in Cognitive Function in Deaf Patients -- 6. Studies Using Deaf Animal Models -- 6.1. Changes in Auditory Cortex Metabolism in the White Rat Model -- 6.2. Molecular Changes in the Auditory Cortex of a Deaf White Rat Model -- 6.3. Electrophysiologic and Metabolic Changes in the Auditory Cortex in a Deaf Cat Model -- 7. Summary and Future Research Directions -- Conclusion -- Acknowledgments -- References -- Chapter VII Pharmacology of New Drugs Used to Improve the Neuroplasticity of the Central Auditory Pathway -- Abstract -- Introduction -- Coenzyme Q10 -- Basic Pharmacology and Toxicity -- Coenzyme Q10 and Neuroprotection -- Experimental and Clinical Data -- Q-TER®: A Water-soluble Formulation of CoQ10 -- Citicoline -- Synthesis of Membrane Phospholipids -- Neurotransmitter Production -- Basic Pharmacology and Toxicity. ; Experimental and Clinical Data -- Conclusion -- References -- Chapter VIII New Drugs to Improve the Neuroplasticity of the Central Auditory Pathway -- Abstract -- Introduction -- Antioxidant Agents -- Methods -- Results -- Discussion -- Conclusion -- References -- Chapter IX Central Auditory System Neuroplasticity and Hippocampal Neurogenesis following Cochlear Insults -- Abstract -- Introduction -- Salicylate-Induced Cochlear Insult -- Acute Salicylate Exposure -- Chronic Salicylate Exposure -- Carboplatin-induced Ototoxicity -- Acoustic Overstimulation -- Conclusion -- Acknowledgments -- References -- Index -- Blank Page.
• Titolo autorizzato: Neuroplasticity in the auditory brainstem
• ISBN: 1-61122-383-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910817769203321
• Lo trovi qui: Univ. Federico II
• Serie: Neurology--laboratory and clinical research development series.; Pharmacology-research, safety testing, and regulation series.