Creatine and creatine phosphate : scientific and clinical perspectives / / [edited by] Michael A. Conway and Joseph F. Clark

• Pubblicazione: San Diego, CA, : Academic Press, c1996
• Descrizione fisica: 1 online resource (257 p.)
• Disciplina: 612.01575
• Soggetto topico: Creatine - Metabolism; Creatine - Physiological effect; Phosphocreatine - Metabolism; Phosphocreatine - Physiological effect
• Altri autori: ConwayMichael A ClarkJoseph F
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Front Cover; Creatine and Creatine Phosphate: Scientific and Clinical Perspectives; Copyright Page; Contents; List of Contributors; A Brief Review of the Sections; Preface; Acknowledgements; Section I: Basic Biochemistry of Creatine and Creatine Phosphate; Chapter 1. Old and New Ideas on the Roles of Phosphagens and their Kinases; 1. Historical introduction to phosphagen kinases; 2. Physiological functions of phosphagen kinases; 3. Use of creatine kinase by the biochemist and physiologist; 4. The phosphoglycerate kinase-glyceraldehyde 3-phosphate dehydrogenase (GAPDH) method ; 5. Comparison of the free ADP concentration estimated by different methods6. Determination of the amount of ADP irreversibly bound to structural protein in the domestic fowl pectoral muscle; References; Chapter 2. Creatine Phosphate Shuttle Pathway in Tissues with Dynamic Energy Demand; 1. Creatine phosphate shuttle hypothesis: cytosolic and mitochondrial CK serve as components of the shuttle; 2. CK in specialized cells: biochemical, physiological and immunological characterization; 3. Subcellular localization of CK; 4. Structure-function analysis of CK; 5. Targeted modification of CK ; 6. Future applications7. Summary; Acknowledgements; References; Chapter 3. Experimental Observations of Creatine and Creatine Phosphate Metabolism; 1. Introduction; 2. NMR studies of ATP and creatine phosphate in the heart; 3. Creatine phosphate metabolism investigated with ß-guanidinopropionic acid; 4. Creatine phosphate in skeletal muscle; 5. Creatine transport; 6. Summary; References; Chapter 4. An Introduction to the Cellular Creatine Kinase System in Contractile Tissue; 1. Introduction; 2. The creatine kinase system in different muscle types; 3. Skeletal muscle; 4. Cardiac muscle ; 5. Smooth muscle6. Summary; References; Chapter 5. Cardiac Energetics: Compartmentation of Creatine Kinase and Regulation of Oxidative Phosphorylation; 1. Introduction; 2. The role of the outer mitochondrial membrane in restricting ADP diffusion and controlling respiration; 3. Metabolic oscillations in cytoplasm as a feedback signal; References; Chapter 6. The Role of the Creatine Kinase/Creatine Phosphate System Studied by Molecular Biology; 1. Introduction; 2. Transgenic knock-out; 3. Muscle performance; 4. Graded CK knock-out; 5. Transgenic overexpression; 6. Summary; Acknowledgements ; ReferencesSection II: Biochemical Basis for a Therapeutic Role of Creatine and Creatine Phosphate; Chapter 7. Molecular and Cellular Mechanisms of Action for the Cardioprotective and Therapeutic Role of Creatine Phosphate; 1. Introduction; 2. Pharmacological effects of exogenous PCr; 3. Calcium dependence of the anti-ischaemic effect of PCr; 4. Protection of the heart from oxidative damage; 5. Effects of PCr on phospholipid metabolism; 6. Other biochemical effects related to the uptake of PCr; 7. Pharmacokinetics of PCr uptake by different tissues; 8. Direct effect of PCr on the cell membrane ; 9. The zwitterionic mechanism of action of PCr
• Sommario/riassunto: Creatine and Creatine Phosphate: Scientific and Clinical Perspectives is an up-to-date summary of both the scientific and medical aspects of creatine and creatine phosphate metabolism and therapy.It covers in detail the basic biochemistry, bioenergetics and biophysics of these agents with particular emphasis on their role on the cardiovascular and muscle systems. Modern in vivo myocardial and skeletal muscle measurements are outlined, and the importance of the molecules in cardiovascular medicine, sport science and cardiac surgery are highlighted.This book is designed for
• Titolo autorizzato: Creatine and creatine phosphate
• ISBN: 1-281-03708-7; 9786611037086; 0-08-053008-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910810781603321
• Lo trovi qui: Univ. Federico II