Block Co-Polymeric Nanocarriers : Design, Concept, and Therapeutic Applications / / edited by Neeraj Mishra and Vikas Pandey

• Pubblicazione: Singapore : , : Springer, , [2023]; ©2023
• Edizione: First edition.
• Descrizione fisica: 1 online resource (440 pages)
• Disciplina: 405
• Soggetto topico: Pharmacology; Polymerization; Nanovaccines; Nanoparticles; Technology, Pharmaceutical
• Persona (resp. second.): MishraNeeraj; PandeyVikas
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Preface -- Acknowledgment -- Contents -- Editors and Contributors -- 1: Development and Synthesis of Block Co-polymer and their Role in Nanotechnology -- 1.1 Introduction -- 1.1.1 Nomenclature -- 1.1.2 Physical Properties -- 1.1.3 Thermal Properties -- 1.1.4 Processability -- 1.1.5 Mechanical Properties -- 1.1.6 Optical Properties -- 1.1.7 Chemical Resistance -- 1.1.8 Transport Properties -- 1.1.9 Blending Properties -- 1.2 Classification of Block Copolymers -- 1.2.1 Based on Chain Length -- 1.2.1.1 Linear Block Copolymer -- 1.2.1.2 Nonlinear Block Copolymers -- 1.2.1.3 Star-Block Copolymers -- 1.2.1.4 Miktoarm Star Copolymers -- 1.2.2 Based on Properties -- 1.2.2.1 Hydrophilic Block Copolymer -- 1.2.2.2 Hydrophobic Block Copolymers -- 1.2.2.3 Amphiphilic Block Copolymers -- 1.3 Synthesis of Block Copolymers with Distinct Structures Can Be Accomplished Using One of Three Main Methods -- 1.3.1 Living Polymerization by Sequential Additions of Different Monomers -- 1.3.2 Living Polymerization of the Original Polymer Chain Via the Addition of a Terminal End -- 1.3.3 Via the Addition of Highly Reactive Functional Groups between Different Polymers in the Final Reaction Step -- 1.3.4 Living Polymerization by Sequential Additions of Different Monomers -- 1.3.4.1 Living Anionic Polymerization -- 1.3.4.2 Living Cationic Polymerization -- 1.3.4.3 Controlled/Living Radical Polymerization -- 1.3.4.4 Other Living Polymerizations Methods -- 1.4 Different Polymeric Formulations and their Pharmaceutical Applications -- 1.4.1 Micelles -- 1.4.2 Hydrogels -- 1.4.3 Polymersomes -- 1.4.4 Cubosomes -- 1.4.5 Other Nanostructure System -- 1.5 Conclusion -- References -- 2: Role of Block Co-Polymers in Drug Delivery -- 2.1 Introduction -- 2.2 Polymeric Nanocarriers for Drug Delivery -- 2.2.1 Nanoparticles -- 2.2.2 Micelles -- 2.2.3 Hydrogel. ; 2.3 Stimuli-Responsive Polymers for Drug Delivery -- 2.3.1 Temperature-Sensitive Drug Delivery Systems -- 2.3.2 Redox-Responsive Polymeric Drug Delivery Systems -- 2.3.3 Light-Responsive Polymeric Drug Delivery Systems -- 2.3.4 Enzyme-Sensitive Polymers -- 2.4 Conclusion and Future Prospects -- References -- 3: Role of Block Copolymers in the Enhancement of Poor Solubility of Drugs -- 3.1 Introduction -- 3.2 Solubility Enhancement by Micelle Formation Using Block-Copolymer -- 3.3 Mechanism of Solubilization by Micelles -- 3.4 Latest Studies on Solubility Enhancement by Micelles Using Block Copolymers -- 3.5 Solubility Enhancement by Solid Dispersion Using Block Copolymer -- 3.6 Technique for Making Solid Dispersions (SDD) -- 3.7 Latest Studies on Solubility Enhancement by SDD Using Block Copolymers -- 3.8 Conclusion -- References -- 4: Synthesis and Self-Assembly of Block Copolymers -- 4.1 Introduction -- 4.2 Methodologies for Synthesis of Block Copolymers -- 4.2.1 Sequential Additions of Various Monomers during Living Polymerization -- 4.2.2 The Process of Initiating another Living Polymerization by Using End-Functional Groups on the Original Polymer Chain -- 4.2.3 End-Linking Reaction between Different Polymers through Highly Reactive Functional Groups -- 4.3 Ionic Polymerization -- 4.3.1 Anionic Polymerization -- 4.3.2 Cationic Polymerization -- 4.4 Ring Opening Polymerization -- 4.5 Radical Chain Polymerization -- 4.5.1 Techniques Involved in Radical Polymerization -- 4.5.1.1 Reversible Addition-Fragmentation Chain Transfer (RAFT) -- RAFT Mechanism -- 4.5.1.2 Atom Transfer Radical Polymerization (ATRP) -- ATRP Mechanism -- Methods for Initiation of ATRP -- 4.5.1.3 Nitroxide Mediated Radical Polymerization (NMP) -- NMP Polymerization -- 4.6 Self-Assembly -- 4.6.1 RAFT Mediated PISA -- 4.6.2 ATRP Mediated PISA -- 4.6.3 NMP Mediated PISA. ; 4.7 Applications -- 4.7.1 Cancer Therapy -- 4.7.2 Vaccine Delivery -- 4.7.3 Biomedical 3D Printing -- 4.7.4 Analgesics -- 4.7.5 Photodynamic Therapy -- 4.7.6 Antimicrobial Therapy -- 4.8 Conclusion -- References -- 5: Role of Block Copolymers in the Treatment of Brain Disorders -- 5.1 Introduction -- 5.2 Brain Disorders -- 5.2.1 Brain Cancer -- 5.2.2 Neurodegenerative Diseases -- 5.2.2.1 Alzheimer´s Disease (AD) -- 5.2.2.2 Parkinson´s Disease (PD) -- 5.3 Crossing the BBB-A Challenge -- 5.4 Applications in Drug Delivery and Release -- 5.5 Coating Polymers -- 5.5.1 Polysorbate (PS) -- 5.5.2 Polyethylene Glycol (PEG) -- 5.5.3 Chitosan -- 5.5.4 Poly- Caprolactone (PCL) -- 5.5.5 Polyacrylic Acid (PACA) -- 5.5.6 Poly (Lactic-Co-Glycolic Acid) (PLGA) -- 5.5.7 Hyaluronic Acid (HUA) -- 5.5.8 Cyclodextrins (CDs) -- 5.5.9 Human Serum Albumin (HSA) -- 5.6 Polymer-Coated Nanoparticles -- 5.7 Challenges -- 5.8 Conclusions and Future Prospective -- References -- 6: Role of Co-Block Polymers in the Treatment of Neurodegenerative Diseases -- 6.1 Introduction -- 6.2 Neurodegenerative Diseases -- 6.3 Blood-Brain Barrier -- 6.4 Role of Nanomedicines in Advanced Therapeutics for Neurodegenerative Diseases -- 6.5 Structural Impact of Block Copolymers and Advantages in the Treatment of Neurodegenerative Diseases -- 6.5.1 Molecular Architecture of co-Block Polymers -- 6.5.2 Self-Assembly and Supramolecular Organisation -- 6.5.3 Physicochemical Properties of co-Block Polymers -- 6.5.4 Target Specificity -- 6.6 Challenges -- 6.6.1 Biocompatibility and Biodistribution -- 6.6.2 Targeting Specificity and Pharmacokinetics -- 6.7 Advantages -- 6.8 Strategies to Transport Therapeutics in Neurodegenerative Diseases Using Block Copolymers -- 6.9 Mechanism of Action of Co-Block Polymers -- 6.9.1 Transport Mechanisms -- 6.9.2 Drug Delivery System. ; 6.9.3 Receptor-Mediated Transcytosis -- 6.9.4 Carrier-Mediated Transcytosis -- 6.9.5 Adsorptive-Mediated Transcytosis -- 6.10 Therapeutic Applications of Co-Block Polymers in Different Neurodegenerative Disease -- 6.11 Clinical Status of Nanomedicines in Neurodegenerative Diseases -- 6.12 Current Status of Recent Advancements of co-Block Polymers -- 6.13 Conclusion and Future Perspectives -- References -- 7: Role of Block Copolymers in Colon Cancer -- 7.1 Introduction -- 7.2 Colon Cancer -- 7.2.1 Classification of CRC -- 7.3 Polymer Used in Management of CRC -- 7.3.1 Biodegradable Polymers -- 7.4 Co-block Polymer and Biomaterials for Treatment of Colon Cancer -- 7.4.1 PEG/PLA -- 7.4.2 PEG/PCL -- 7.5 Therapeutic Approach for Management of Colon Cancer -- 7.6 Polymeric Nanostructures for Management of Colon Cancer -- 7.6.1 Polymeric Micelles -- 7.6.2 Nanogels -- 7.6.3 Polymeric Nanocapsules -- 7.6.4 Dendrimers -- 7.7 Challenges and New Perspectives -- 7.8 Conclusion -- References -- 8: Role of Copolymers in Lung Cancer -- 8.1 Introduction -- 8.1.1 Block Copolymers -- 8.1.2 Classification of Block Copolymers -- 8.1.2.1 Hydrophilic Copolymer -- 8.1.2.2 Hydrophobic Block Copolymer -- 8.1.2.3 Amphiphilic Block Copolymer -- 8.2 Various Copolymers Used in Drug Delivery -- 8.2.1 Chitosan Derivatives -- 8.2.2 Hyaluronic Acid, Poly(Glycolic Acid) and Poly(Lactic Acid) -- 8.2.3 Poly(N-Isopropyl Acrylamide)s -- 8.2.4 Poly(N-(2-Hydroxypropyl) Meth-Acrylamide)s -- 8.2.5 Polyethylenimine Copolymers -- 8.3 Implication of Polymeric Nanocarriers in Lung Cancer -- 8.3.1 Hydrogels -- 8.3.2 Micelles -- 8.3.3 Nanoparticles -- 8.4 Conclusion -- 8.5 Future Perspectives -- References -- 9: An Insight to Block Copolymers in Inflammatory Bowel Disease Management -- 9.1 Introduction -- 9.2 Pathophysiology of Inflammatory Bowel Disease (IBD) -- 9.3 Current Drug Therapy for IBD. ; 9.4 Block Copolymer -- 9.4.1 Synthesis of BCPs -- 9.4.2 Controlled Polymerization -- 9.4.3 Living Anionic Polymerization -- 9.4.4 Combination of Various Polymerization Strategies -- 9.4.5 Self-Assembly in Solution -- 9.5 Mechanism of Uptake of Block Copolymer Based Nano-System in IBD -- 9.6 Applications and Delivery Systems for Block Copolymers -- 9.6.1 Nanoparticles -- 9.6.2 Micelles -- 9.6.3 Polymersomes -- 9.6.4 Hydrogels -- 9.6.5 Various Other Nanosystems -- 9.7 Role of BCP in IBD -- 9.8 Advantage of BCP over Other Delivery System -- 9.9 Importance of BCP in IBD -- 9.10 Conclusion and Future Prospect -- References -- 10: Role of Block Copolymers in Vaccines -- 10.1 Introduction -- 10.2 Advantages of Block Copolymer Over Conventional Polymer Used in Vaccine -- 10.2.1 Enhances Stability -- 10.2.2 Improves Solubility and Bioavailability -- 10.2.3 Targeted Drug Delivery -- 10.2.4 Adjuvant Properties -- 10.3 Application of Block Copolymers in Vaccine Delivery -- 10.3.1 As a Nanocarrier for Vaccine Delivery -- 10.3.1.1 Biodegradable Polymeric Nanoparticles -- 10.3.1.2 Micelles -- 10.3.1.3 Microspheres -- 10.3.1.4 Nanogel -- 10.3.2 As an Adjuvant for Vaccine Delivery -- 10.3.2.1 Types of Adjuvants -- Inorganic Adjuvants -- Aluminum Adjuvant -- Graphene Oxide -- Organic -- Polymer Adjuvants -- 10.4 Recent Developments in Vaccine Preparation with Block Copolymer -- 10.5 Side Effects of Block Copolymer in Vaccine Delivery -- 10.5.1 Immunogenicity -- 10.5.2 Toxicity -- 10.5.3 Interference with Vaccine Efficacy -- 10.5.4 Physiological Effects -- 10.6 Block Copolymer Safety, Handling, and Cost -- 10.6.1 Safety -- 10.6.2 Handling -- 10.6.3 Price -- 10.7 Marketed Vaccines Containing Block Copolymer -- 10.8 Conclusions -- References -- 11: Role of Block Copolymer in the Treatment of GIT Disorder -- 11.1 Introduction -- 11.2 Self-Assembly. ; 11.2.1 Thin Film-Based BCP Self-Assembly.
• Titolo autorizzato: Block Co-Polymeric Nanocarriers
• ISBN: 981-9969-17-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910767516903321
• Lo trovi qui: Univ. Federico II