Cell biology and translational medicine . Volume 17 : stem cells in tissue differentiation, regulation and disease / / edited by Kursad Turksen

• Pubblicazione: Cham, Switzerland : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (249 pages)
• Disciplina: 617.51
• Soggetto topico: Regenerative medicine
• Persona (resp. second.): TurksenKursad
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- Preface -- Contents -- Endothelialization and Inflammatory Reactions After Intracardiac Device Implantation -- 1 Introduction -- 2 Intracardiac Devices -- 2.1 PFO Occluders -- 2.1.1 Amplatzer PFO Occluder -- 2.1.2 Gore Septal Occluder -- 2.1.3 Flex II PFO Occluder -- 2.2 ASD Occluders -- 2.2.1 Amplatzer Septal Occluder -- 2.2.2 Occlutech ASD Occluder -- 2.3 Left Atrial Appendage Occluders -- 2.3.1 Watchman Device -- 2.3.2 Amulet Occluder -- 2.4 Transcatheter Aortic Valve Implantation -- 2.4.1 Edwards SAPIEN 3/SAPIEN 3 Ultra -- 2.4.2 Medtronic Evolut R/Evolut PRO -- 2.5 Leadless Pacemakers -- 3 Common Device Components -- 3.1 Nitinol -- 3.2 Titanium -- 3.3 Tungsten -- 3.4 Gold -- 3.5 Steel -- 4 Cardiac Injury, Wound Healing, and Regeneration - A Brief Overview -- 4.1 Pro-inflammatory Phase -- 4.2 Cell Proliferation Phase -- 4.3 Endothelialization and Resolution of Inflammation -- 5 Discussion -- 6 Conclusion -- 7 Limitations -- References -- Articular Cartilage Regeneration in Veterinary Medicine -- 1 Cartilage and Its (In)Ability to Heal -- 2 Osteoarthritis in Companion Animals -- 3 Pain Management of OA -- 3.1 Conservative Treatment -- 3.2 Novel Pain Management Treatment Options -- 3.2.1 Platelet-Rich Plasma -- 3.2.2 Anti-nerve Growth Factor Monoclonal Antibodies Therapy -- 3.2.3 Mesenchymal Stem Cells/Medicinal Signaling Cells -- 4 Surgical Treatment of OA and Cartilage Defects -- 4.1 Conventional Treatment Options -- 4.2 Reparative Treatment Techniques -- 4.3 Regenerative Treatment Options -- 4.3.1 Osteochondral Transplantation -- 4.3.2 Autologous Chondrocyte Implantation -- 4.3.3 Matrix-Induced ACI (MACI) -- 5 Attempts to Improve Existing Regenerative Treatment Options with the Use of Mesenchymal Stem Cells -- 5.1 Chondrogenic Differentiation of MSCs -- 5.2 Hypertrophy Associated with Chondrogenic Differentiation of MSCs. ; 5.3 Attempts at Reduction of MSC Hypertrophy -- 5.3.1 Co-culture -- 5.3.2 PTHrP -- 5.3.3 Matrilin-3 -- 5.3.4 Hypoxia -- 5.4 Biomaterials for Mimicking Native Cartilage Tissue -- 5.4.1 The Influence of the 3D Structure on MSCs -- 5.4.2 Influence of Biomaterial Properties on MSCS -- 5.4.3 General Structure of Biomaterials for Cell Encapsulation -- 5.4.4 Natural Biomaterials to Promote MSC Chondrogenesis -- Collagen -- Hyaluronic Acid -- Silk Fibroin -- Decellularized Cartilage Matrix -- 5.4.5 Role of Mechanical Stimulation in Cartilage Regeneration -- 5.4.6 Importance of Biomaterial Architecture -- 6 Summary -- References -- Adult Stem Cell Therapy as Regenerative Medicine for End-Stage Liver Disease -- 1 End-Stage Liver Disease -- 2 Liver Development and Regeneration -- 3 Stem Cell Therapy -- 3.1 Mesenchymal Stem Cells -- 3.2 Hematopoietic Stem Cells -- 3.3 Endothelial Progenitor Cells -- 3.4 Fetal Human Hepatocytes -- 3.5 Hepatic Lineage Differentiation -- 4 Cell Reprogramming -- 4.1 Induced Pluripotent Stem Cells (iPSC) -- 4.2 Human Liver Organoids (HLO) -- 5 General Perspective -- References -- An Affordable Approach of Mesenchymal Stem Cell Therapy in Treating Perianal Fistula Treatment -- 1 Introduction -- 2 Pathophysiology of Perianal Fistula -- 3 Mechanism of Action of MSCs -- 3.1 Homing Ability -- 3.2 Anti-Inflammatory Mechanism -- 3.3 Cell Proliferation Stage -- 3.4 Re-epithelisation and Tissue Remodelling -- 4 A more Affordable MSC Therapy in Treating PF -- 4.1 Cell Source -- 4.2 Manufacturing Scales -- 4.3 Preconditioning of MSCs -- 4.4 Genetically Modified MSCs -- 4.4.1 Improving Migration -- 4.4.2 Reduced Premature/Replicative Senescence -- 4.4.3 Cost -- 4.5 Cell-Free Therapy -- 5 Remaining Challenges and Conclusion -- References -- Virus, Exosome, and MicroRNA: New Insights into Autophagy -- 1 Autophagy -- 2 MicroRNA and Autophagy. ; 2.1 Regulation of Autophagy by MicroRNAs -- 2.2 MiRNAs Interactions in Chemo-Induced Autophagy -- 3 Exosome and Autophagy -- 4 Inhibition or Stimulation of Autophagy by the Virus -- 5 Autophagy Supporting Viral Replication -- 6 Conclusion -- References -- Epitranscriptomics Changes the Play: m6A RNA Modifications in Apoptosis -- 1 Introduction -- 2 Apoptosis -- 3 m6A RNA Modification -- 3.1 Deposition of m6A Modification -- 3.2 Fates of m6A Methylated RNAs -- 4 m6A Modifications in Apoptosis -- References -- The Fingerprints of Biomedical Science in Internal Medicine -- 1 Introduction -- 2 Internal Medicine: Background and Present Status -- 2.1 Common Diagnostic Methods -- 2.2 Common Treatment Options -- 3 Biomedical Science: Subsets and Applications -- 3.1 Cellular and Molecular Biology -- 3.1.1 Biochemistry -- 3.1.2 Genetics -- 3.2 Bioinformatics -- 3.3 Bioengineering -- 3.4 Bionanotechnology -- 3.5 Microbiology -- 3.6 Embryology -- 3.7 Physiology -- 4 Molecular Diagnostics and Multi-Omics Approaches -- 4.1 Molecular Imaging -- 4.2 Single-Cell Multi-Omics Analysis -- 5 Advanced Preclinical Models -- 6 The Next Generation of Treatments -- 6.1 Cell-Based Therapies -- 6.2 Gene-Based Therapies -- 6.3 Regenerative Personalized Medicine -- 7 Conclusion and Future Perspectives -- References -- Mesenchymal Stem Cell-Derived Extracellular Vesicles: Progress and Remaining Hurdles in Developing Regulatory Compliant Qualit... -- 1 Introductions -- 2 Biological Characterization of MSC-EVs -- 2.1 Current Scenario on MSC-EV Characterization Assays -- 3 Quality Control Regulation for MSC-EVs -- 3.1 Establishing QC Assays for EV-Based Products -- 4 Remaining Challenges -- 5 Conclusion -- References -- Pharmacological Effects of Caffeic Acid and Its Derivatives in Cancer: New Targeted Compounds for the Mitochondria -- 1 Background -- 2 Mitochondria in Cancer Cells. ; 3 Antineoplastic Agents Targeting Mitochondrial Function -- 4 Polyphenols as Antitumoral Agents -- 5 Caffeic Acid and Its Derivatives with Antitumoral Action -- 6 Mitochondriotropic Derivatives of Caffeic Acid -- 7 Conclusion -- References -- Systematically Assessing Natural Compounds´ Wound Healing Potential with Spheroid and Scratch Assays -- 1 Introduction -- 2 Materials and Methods -- 2.1 Cells and Culture Conditions -- 2.2 Spheroid Formation for Compound Screening -- 2.3 Dissolving Natural Compounds: Spheroid Treatment -- 2.4 Cell Viability and Stains -- 2.5 Scratch Wounds -- 2.6 Imaging and Measurements -- 2.7 Histology -- 2.8 Statistics -- 3 Results -- 3.1 NIH 3T3 Spheroids Self-Assemble from Cell Sheets in the Absence of Extracellular Matrix -- 3.2 Manuka Honey Is a Spheroid-Supporting Compound -- 3.3 Manuka Honey Increases Cell Motility in Scratch Wound Assays -- 4 Discussion -- 4.1 Scaffold-Free Spheroids from NIH 3T3 Cells Form by Substrate-Specific Collective Cellular Processes from Cell Sheets -- 4.2 Using Spheroids and Scratch Wound Healing Assays to Screen Natural Compounds -- 4.3 Usefulness of Our Proposed Workflow -- References -- Index.
• Titolo autorizzato: Cell biology and translational medicine
• ISBN: 9783031205149; 9783031205132
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910624305003321
• Lo trovi qui: Univ. Federico II
• Serie: Advances in Experimental Medicine and Biology