A roadmap to nonhematopoietic stem cell-based therapeutics : from the bench to the clinic / / editor, Xiao-Dong Chen

• Pubblicazione: London : , : Academic Press, , [2019]; ©2019
• Descrizione fisica: 1 online resource (660 pages) : illustrations
• Disciplina: 616.02774
• Soggetto topico: Stem cells - Therapeutic use; Stem cells - Research
• Persona (resp. second.): ChenXiao Dong
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Part I. Principles & concepts -- What can we learn from this book? -- Features of mesenchymal stem cells -- Maintenance and culture of MSCs -- Manufacturing mesenchymal stromal cell banks -- Part II. Promises and challenges of MSC-based therapies -- Mesenchymal stem cell-based therapy of osteoarthritis: current clinical developments and future therapeutic strategies -- Mesenchymal stem cell therapy in graft versus host disease -- Systemic lupus erythematosus -- Mesenchymal stem cell-based therapies for repair and regeneration of skin wounds -- Myocardial infarction -- Bone marrow mesenchymal stem cells as a new therapeutic approach for diabetes mellitus -- Mesenchymal stem cell-based therapy for chronic kidney disease -- Promises and challenges of MSC-based therapies: Parkinson disease and Parkinsonism -- Spinal cord injury -- Stem cell-based restoration of salivary gland function -- Tooth and dental pulp regeneration -- Part III. Future perspectives -- MSCs as biological drugs -- Mesenchymal stem cell-derived products for tissue repair and regeneration -- Use of MSCs in antiaging strategies -- Regulatory developments for nonhematopoietic stem cell therapeutics: perspectives from the EU, the USA, Japan, China, India, Argentina, and Brazil.
• Sommario/riassunto: A Roadmap to Non-hematopoietic Stem Cell-Based Therapeutics: From the Bench to the Clinic is a resource that provides an overview of the principles of stem cell therapy, the promises and challenges of using stem cells for treating various clinical conditions, and future perspectives. The overall goal is to facilitate the translation of basic research on stem cells to clinical applications. The properties of stem cells from various sources are reviewed and the advantages and disadvantages of each for clinical use are discussed. Modifying stem cell properties through preconditioning strategies using physical, chemical, genetic, and molecular manipulation to improve cell survival, increase cell differentiation potential, enhance production of paracrine factors, and facilitate homing to the site of injury or disease upon transplantation are reviewed. Various routes of stem cell administration and dosing, and the duration of effects, are explored. Individual chapters are written by experts in the field and focus on the use of stem cells in treating various degenerative diseases, autoimmune diseases, wound healing, cardiovascular disease, spinal cord injury, oral and dental diseases, and skeletal disorders. Finally, experts in the regulatory arena discuss mechanisms used in different countries for approving the use of stem cells to treat diseases and many common issues that are typically encountered while seeking approval for this class of therapeutic agent.--
• Titolo autorizzato: A roadmap to nonhematopoietic stem cell-based therapeutics
• ISBN: 0-12-811921-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910583035303321
• Lo trovi qui: Univ. Federico II