Mid-size Drugs Based on Peptides and Peptidomimetics : A New Drug Category / / by Hirokazu Tamamura, Takuya Kobayakawa, Nami Ohashi

• Autore: Tamamura Hirokazu
• Pubblicazione: Singapore : , : Springer Singapore : , : Imprint : Springer, , 2018
• Edizione: 1st ed. 2018.
• Descrizione fisica: 1 online resource (XVII, 100 p. 40 illus., 32 illus. in color.)
• Disciplina: 540
• Soggetto topico: Medicinal chemistry; Pharmaceutical technology; Organic chemistry; Medicinal Chemistry; Pharmaceutical Sciences/Technology; Organic Chemistry
• Persona (resp. second.): KobayakawaTakuya; OhashiNami
• Nota di bibliografia: Includes bibliographical references at the end of each chapters.
• Nota di contenuto: 1. Introduction of Mid-Size Drugs and Peptidomimetics -- 2. Chloroalkene Dipeptide Isosteres as Peptidomimetics -- 3. Conformational-restricted Cyclic Peptides -- 4. Peptidomimetics that Mimic Secondary Structures of Peptides -- 5.Peptidomimetics that Mimic Tertiary Structures of Peptides -- 6. Conjugated Compounds Involving Peptides -- 7. Summary and Future Perspectives of Researches on Mid-Size Drugs.
• Sommario/riassunto: This brief describes studies conducted by the authors on mid-size drugs utilizing peptides and peptidomimetics, and on the development of anti-HIV agents. Peptides are important biological molecules and have various physiological actions. Peptide-based drug discovery may help bring about the development of useful medicines that are highly safe and show potent pharmacological effects in small doses. Recently, it has been shown that there is an important drug-like space in the mid-sized region between low- and high-molecular-weight compounds. Thus, mid-size drugs such as peptide compounds are being focused on. To date, several peptidomimetics that mimic primary, secondary, and tertiary structures of peptides have been developed to maintain and improve biological activities and actions of peptides. In this book, the features and advantages of mid-size drugs are described in detail. In addition, the merits of utilizing peptidomimetics in the development of mid-size drugs are referred to. Understanding such peptide-derived mid-size drugs will lead to a comprehensive expansion of medicinal chemistry.
• Titolo autorizzato: Mid-size Drugs Based on Peptides and Peptidomimetics
• ISBN: 981-10-7691-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910300440003321
• Lo trovi qui: Univ. Federico II
• Serie: SpringerBriefs in Pharmaceutical Science & Drug Development, . 1864-8118