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Titolo: |
Biology of IGF-1 [[electronic resource] ] : its interaction with insulin in health and malignant states / / [edited by Gregory Bock, Jamie Goode]
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Pubblicazione: | The Atrium, Southern Gate, Chichester, UK ; ; Hoboken, NJ, : John Wiley & Sons, c2004 |
Descrizione fisica: | 1 online resource (294 p.) |
Disciplina: | 612.01575 |
612/.015756 | |
Soggetto topico: | Somatomedin - Physiological effect |
Somatomedin - Pathophysiology | |
Carcinogenesis | |
Soggetto genere / forma: | Electronic books. |
Classificazione: | 44.78 |
Altri autori: |
BockGregory
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Note generali: | Description based upon print version of record. |
Nota di bibliografia: | Includes bibliographical references and indexes. |
Nota di contenuto: | Circulating IGF-I and its role in cancer: lessons from the IGF-1 gene-deletion (LID) mouse -- Physiology of the IGF system -- Molecular basis of insulin action -- IGF-1 and insulin as growth hormones -- Insulin-like growth factors and neoplasia -- Loss of IGF2 imprinting: mechanisms and consequences -- Insulin and IGF-1 receptor trafficking and signalling -- The mTOR/S6K signalling pathway: the role of the TSC1/2 tumour suppressor complex and the proto-oncogene Rheb -- Structural biology of insulin and IGF-1 receptors -- Genetic blockade of the insulin-like growth factor-I receptor for human malignancy -- IGF-1 and prostate cancer -- IGF-1 and breast cancer -- IGFBPs and cancer -- The IGF receptor as anticancer treatment target -- Nutrition, insulin, IGF-1 metabolism and cancer risk: a summary of epidemiological evidence. |
Sommario/riassunto: | An invaluable book containing a series of interdisciplinary discussions between clinical and basic scientists. Biology of IGF-1: Its interaction with insulin and health and malignant states focuses on key issues such as:the definition of danger zonesthe development of methods for early recognition of malignant states linked to IGF-1 and/or insulinpossible approaches to preventative interventionthe relevance in this field of research to the development of novel therapeutic approaches to treating certain cancers. |
Titolo autorizzato: | Biology of IGF-1 ![]() |
ISBN: | 1-280-27251-1 |
9786610272518 | |
0-470-66753-2 | |
0-470-86997-6 | |
0-470-86999-2 | |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910143555703321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |