Human Semen Analysis : From the WHO Manual to the Clinical Management of Infertile Men

• Autore: Agarwal Ashok
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (380 pages)
• Altri autori: BoitrelleFlorence SalehRamadan ShahRupin
• Nota di contenuto: Intro -- Foreword -- Preface -- Contents -- About the Editors -- Part I: WHO Manual for Human Semen Analysis -- 1: Historical View: From First to the Sixth WHO Manual -- Introduction -- Major Advances in Each of the WHO Editions -- What Is New in the Sixth Edition of the WHO Manual of Semen Analysis? -- Practical Considerations and Expert Opinion -- References -- Part II: Basic Semen Examinations in Clinical Practice -- 2: Role of Semen Examination in the Couple's Fertility Assessment -- Introduction -- Semen Analysis in the Initial Work-Up of the Infertile Couple -- Basic Semen Parameters -- Extended Tests -- Advanced Tests -- Conclusions -- References -- 3: Macroscopic Semen Parameters -- Introduction -- Physiology of Human Ejaculate -- Macroscopic Parameters of Semen: Methodological Considerations -- Collection of Semen Samples -- Liquefaction of Semen -- Viscosity of Semen -- Semen Colour -- Hemospermia -- Semen Odour -- Semen pH -- Semen Volume -- Summary -- References -- 4: Sperm Concentration and Total Sperm Count -- Introduction -- Physiology: Methodology of Sperm Concentration and Total Sperm Count Testing -- Explaining the Test -- Significance of Sperm Count -- Natural Variation -- More Than One Test May Be Required -- Special Measures If Count Is Very Low -- Sperm Count/Concentration and Diagnosis of Fertility and Infertility -- Reference Ranges Employed by the WHO Manual -- Sperm Count/Concentration and Etiological Diagnosis of Male Reproductive Functions and Dysfunction -- Causes Implied in Sperm Count/Concentration Decreasing -- Sperm Count/Concentration Planning of Further Investigations -- Sperm Count/Concentration and Non-ART Management: Treatment and Treatment Response Monitoring -- Management of Oligozoospermic Patient Using Hormonal Treatment -- Management of Oligozoospermic Patient Using Antioxidants. ; Management of Oligozoospermic Patient with Varicocelectomy -- Sperm Count/Concentration and ART Management: Guide ART Choice -- ART for Oligozoospermia -- IUI -- IVF/ICSI -- Cryopreservation -- Surgical Sperm Retrieval -- Two Clinical Scenarios -- Case 1 -- Case 2 -- References -- 5: Sperm Motility -- Introduction -- Physiology: Methodology of Sperm Motility Testing -- Sperm Motility and Diagnosis of Fertility and Infertility -- Sperm Motility and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Flagellar/Ciliary Defects and Sperm Motility -- Energy-Driven Concept of Sperm Motility -- Sperm Motility and Lifestyle and Environmental Factors -- The Role of Ion Channels in Sperm Motility -- Genetic Contribution to Sperm Motility -- Role of Sexual Abstinence -- Drugs Affecting Sperm Motility -- Heat Exposure and Sperm Motility -- Psychological Stress Affecting Sperm Motility -- Infection and Sperm Motility -- Sperm Motility and Planning Further Investigations -- Oxidative Stress Evaluation -- Genetic Testing -- Structural Sperm Abnormalities -- Ion Transport Channels -- Mitochondrial Gene Mutations -- Antisperm Antibody (ASA) Testing -- Microbiological Investigation -- Sperm Motility and Non-ART Management: Treatment and Treatment Response Monitoring -- Varicocele Repair for Isolated Asthenozoospermia -- Sperm Motility and ART Management: Guide to ART Choice -- Threshold for IUI in Male Factor Infertility -- Thresholds for IVF -- In Vitro Enhancement of Motility -- Absolute Asthenozoospermia Vs. Absolute Necrozoospermia -- Flagellar Dyskinesia and Primary Ciliary Dyskinesia (PCD) -- Clinical Scenarios -- Case Scenario 1 -- Case Scenario 2 -- Clinical Decision Tree -- ART Management of Male Factor Infertility (Oligoasthenospermia): After Non-ART management has failed (A and B) -- A. Considerations for IUI for Oligoasthenospermia. ; B. ART Considerations for Severe Oligoasthenospermia -- ART Considerations for Absolute Necrozoospermia -- ART Considerations for Absolute Asthenozoospermia -- Non-ART Management of Asthenospermia -- References -- 6: Sperm Vitality -- Introduction -- Physiology: Methodology of Sperm Vitality Testing -- Tests for Sperm Vitality Assessment -- Sperm Vitality and Diagnosis of Fertility and Infertility -- Sperm Vitality and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Ageing -- Tobacco -- Alcohol -- Overweight and Metabolic Syndrome -- Endocrinopathies -- Medications -- Radiofrequencies and Radiations -- Environmental and Occupational Pollutants -- Genital Infections -- Systemic Infections -- Urological Disease -- Varicocele -- Sperm Vitality and Planning of Further Investigations -- Sperm Vitality and Non-ART Management: Treatment and Treatment Response Monitoring -- Modifiable Risk Factors Corrections -- Repeated Ejaculation -- Antibiotic Therapy -- Varicocele Correction -- Antioxidants -- Timing for Reassessment -- Sperm Vitality and ART Management: Guide ART Choice -- Two Clinical Scenarios -- Clinical Scenario #1 -- How Should the Patient Be Managed? -- Clinical Scenario #2 -- How Should the Patient Be Managed? -- References -- 7: Sperm Morphology -- Introduction -- Physiology: Methodology of Sperm morphology Testing -- Sperm Morphology and Diagnosis of Fertility and Infertility -- Sperm Morphology and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- Tobacco and Cannabis -- Alcohol Consumption -- Overweight/Obesity -- Environmental and Occupational Pollutants -- Varicocele -- Infections -- Testicular Cancer -- Diabetes -- Genetic Causes -- Sperm Morphological Abnormalities -- Globozoospermia -- Macrozoospermia -- Microcephalic and Thin Heads -- Tapered Sperm Head. ; Pinhead/Acephalic/Decapitated Spermatozoa -- Excess Residual Cytoplasm -- Sperm Tail Abnormalities -- Sperm Morphology and Planning of Further Investigations -- Sperm Morphology and Non-ART Management: Treatment and Treatment Response Monitoring -- Sperm Morphology and ART Management: Guiding ART Choices -- Have We Become Too Strict? -- Testicular Versus Ejaculated Sperm -- The Correlation of Sperm Morphological Profile and Particular Clinical Conditions -- Definition and Types of Multiple Sperm Defects -- The Clinical Importance of Reporting All of the Morphological Abnormalities -- Two Clinical Scenarios -- Case 1 -- Case 2 -- References -- 8: Sperm Agglutination -- Introduction -- Physiology: Methodology of Sperm Agglutinates Testing -- Direct Antiglobulin Test -- Mixed Antiglobulin Reaction (MAR) Test -- The Immunobead Test (IB) -- Indirect Antiglobulin Test -- Limitation of the Test -- ASAB and Male Reproductive Function and Dysfunction -- Risk Factors of ASAB Formation -- Varicocele -- Vasectomy -- Infection -- Other Uncommon Risk Factors for ASAB Formation -- Potential Targets of ASAB -- ASAB and Diagnosis of Fertility and Infertility -- Reference Ranges Used by the WHO Manual of Semen Analysis -- Scoring of Agglutination -- ASAB and Planning of Further Investigations -- Management of ASAB -- ASAB and ART Outcome -- Clinical Scenarios -- Case 1 -- Case 2 -- Future Perspectives -- References -- 9: Leukocytospermia and Bacteriospermia -- Introduction -- Relationship of Bacteriospermia and Leukocytospermia -- Impact of Bacteriospermia on Male Reproductive Function -- Impact of Leukocytospermia on Male Fertility Potential -- Clinical Significance of Leukocytospermia -- Types of Round Cells -- Methods for Identifying Seminal Leukocytes -- Peroxidase Tests -- Ortho-Toluidine Test -- Endtz Test -- Immunochemistry -- Seminal Granulocyte Elastase Test. ; Is the Threshold of 1 × 106 WBC/ml Semen Reliable for Defining Leukocytospermia? -- Management of Leukocytospermia in the Context of Male Infertility -- Follow-Up of Leukocytospermia Cases -- Role of Assisted Reproductive Techniques in the Treatment of Infertile Men with Leukocytospermia -- Swim-Up -- Glass Wool Filtration -- Mechanical Filtration -- Density Gradient Centrifugation -- Microfluidics -- Impact of Leukocytospermia on ART Outcome -- Decisional Tree/Clinical Guide for Non-ART and ART Management of Leukocytospermia is presented in Figs. 9.1 and 9.2, Respectively -- Clinical Scenarios -- Clinical Scenario 1 -- Clinical Scenario 2 -- References -- Part III: Extended Examinations in Clinical Practice -- 10: Sperm DNA Fragmentation -- Introduction -- Pathophysiology of SDF and Methodology of SDF Testing -- Relationship Between Sperm DNA Test Results and Reproductive Outcomes -- SDF and Etiological Diagnosis of Male Reproductive Functions and Dysfunctions -- SDF and Further Investigations -- SDF: Non-ART Management -- SDF and ART Management: Guide ART Choice -- Short Abstinence -- Advanced Sperm Processing Techniques -- Use of Testicular Sperm for ICSI in Men with High Levels of Sperm DNA Fragmentation -- Two Case Scenarios -- References -- 11: Genetic Screening for Sperm Aneuploidy by Fluorescent In Situ Hybridization (FISH) in Severe Cases of Male Infertility -- Introduction -- Chromosomal Content in Sperm, How to Measure It -- How Sperm Ploidy Is Related with Male Fertility -- Baseline Sperm Aneuploidies in Normozoospermic and Fertile Controls -- Sperm Aneuploidies in Infertile Males -- Sperm Aneuploidies in Low Quality Sperm Samples -- Reproductive Outcomes in ART from Men Presenting Sperm Aneuploidies -- Preimplantation Genetic Testing for Aneuploidy (PGT-A) in Patients with Increased Sperm Aneuploidy. ; Solving Reproductive Problems Linked with Sperm Aneuploidy.
• Titolo autorizzato: Human Semen Analysis
• ISBN: 9783031553370
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910874655903321
• Lo trovi qui: Univ. Federico II