Bioactive carboxylic compound classes : pharmaceuticals and agrochemicals / / edited by Clemens Lamberth and Jürgen Dinges

• Pubblicazione: Weinheim, Germany : , : Wiley-VCH Verlag, , 2016; ©2016
• Descrizione fisica: 1 online resource (529 p.)
• Disciplina: 630.24
• Soggetto topico: Agricultural chemicals
• Persona (resp. second.): LamberthClemens; DingesJürgen
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 Different Roles of Carboxylic Functions in Pharmaceuticals and Agrochemicals; 1.1 Introduction; 1.2 Solubilizer; 1.3 Pharmacophore; 1.4 Prodrug; 1.5 Bioisosteric Replacement; 1.6 Scaffold; 1.7 Conclusion; References; Part I Neurology; Chapter 2 Carboxylic Ester Containing Norepinephrine-Dopamine Reuptake Inhibitors (NDRIs); 2.1 Introduction; 2.2 History; 2.3 Synthesis; 2.4 Mode of Action; 2.5 Structure-Activity Relationships; References; Chapter 3 Analgesic and Anesthetic Amides; 3.1 Introduction; 3.2 History ; 3.3 Synthesis3.4 Mode of Action; 3.5 Structure-Activity Relationships; References; Part II Cardiovascular Diseases; Chapter 4 Fibrate Acids and Esters for the Treatment of Hyperlipidemia (PPARa Activators); 4.1 Introduction; 4.2 History; 4.3 Synthesis; 4.4 Mode of Action; 4.5 Structure-Activity Relationships; References; Chapter 5 Antiplatelet 2-Hydroxy Thienopyridine Ester Derivatives for the Reduction of Thrombotic Cardiovascular Events; 5.1 Introduction; 5.2 History; 5.3 Synthesis; 5.4 Mode of Action; 5.5 Structure-Activity Relationships; References ; Chapter 6 Carboxylic Acids and Lactones as HMG-CoA Reductase Inhibitors6.1 Introduction; 6.2 History; 6.3 Synthesis; 6.4 Mode of Action; 6.5 Structure-Activity Relationship; References; Chapter 7 Angiotensin II Receptor Antagonists with Carboxylic Functionalities in Cardiovascular Disease; 7.1 Introduction; 7.2 History; 7.3 Synthesis; 7.4 Mode of Action; 7.5 Structure-Activity Relationships; References; Chapter 8 Carboxylic Acid Containing Direct Thrombin Inhibitors for the Treatment of Thromboembolic Diseases; 8.1 Introduction; 8.2 History; 8.3 Synthesis; 8.4 Mode of Action ; 8.5 Structure-Activity RelationshipReferences; Part III Infectious Diseases; Chapter 9 Tetracycline Amide Antibiotics; 9.1 Introduction; 9.2 History; 9.2.1 First-Generation Tetracyclines - The Discovery; 9.2.2 Second-Generation Semisynthetic Tetracyclines; 9.2.3 Tetracycline Resistance; 9.2.4 Third-Generation Tetracyclines; 9.3 Synthesis; 9.4 Mode of Action; 9.5 Structure-Activity Relationships; References; Chapter 10 Carboxylic-Acid-Based Neuraminidase Inhibitors; 10.1 Introduction; 10.2 History; 10.3 Synthesis; 10.4 Mode of Action; 10.5 Structure-Activity Relationships; References ; Chapter 11 Oxazolidinone Amide Antibiotics11.1 Introduction; 11.2 History; 11.3 Synthesis; 11.4 Mechanism of Action; 11.5 Structure-Activity Relationships; References; Chapter 12 Sovaldi, an NS5B RNA Polymerase-Inhibiting Carboxylic Acid Ester Used for the Treatment of Hepatitis C Infection; 12.1 Introduction; 12.2 History; 12.3 Synthesis; 12.4 Mode of Action; 12.5 Structure-Activity Relationships; References; Part IV Metabolic Diseases; Chapter 13 Dipeptidyl Peptidase-4 (DPP-4)-Inhibiting Amides for the Treatment of Diabetes; 13.1 Introduction; 13.2 History; 13.3 Synthesis ; 13.4 Mode of Action
• Titolo autorizzato: Bioactive carboxylic compound classes
• ISBN: 3-527-69394-7; 3-527-69393-9; 3-527-69396-3
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Tedesco
• Record Nr.: 9910831027203321
• Lo trovi qui: Univ. Federico II