DNA vaccines [[electronic resource] ] : types, advantages and limitations / / Erin C. Donnelly and Arthur M. Dixon, editors

• Pubblicazione: Hauppauge, N.Y., : Nova Science, c2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (214 p.)
• Disciplina: 615/.372
• Soggetto topico: DNA vaccines
• Altri autori: DonnellyErin C DixonArthur M
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- DNA VACCINES: TYPES, ADVANTAGES AND LIMITATIONS -- DNA VACCINES: TYPES, ADVANTAGES AND LIMITATIONS -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Chapter I Novel Carrier Adjuvant for DNA Vaccination -- Abstract -- 1. Introduction -- 2. Immunology of DNA Vaccines: Mode of Action and Immune Response Induction -- 3. Barriers in DNA Vaccine Delivery and Possible Modes to Overcome these Barriers -- 4. Novel Strategies for DNA Delivery -- 4.1. Lipid Based Carrier Adjuvants for DNA Vaccination -- 4.1.1. Liposomes -- 4.1.2. Virosomes -- 4.2. Polymers and Polymeric Carriers Systems -- 4.2.1. Polyethylenimine -- 4.2.2. Polylysine -- 4.2.3. Chitosan -- 4.2.4. Dendrimers -- 4.2.5. Poly (Lactide-Co-Glycolide) (PLG) -- 5. Concluding Remark and Future Prospects -- References -- Chapter II Improving the Immunogenicity of DNA Vaccines: A Nano-Sized Task? -- Abstract -- Introduction -- Improving Immunogenicity of Plasmid DNA Vaccines -- Routes of Delivery of Plasmid DNA Vaccines -- Physical Delivery Systems of Plasmid DNA Vaccines -- Needle-Free Delivery Methods -- Expression Optimization -- Cytokines -- Delivery Vectors for DNA Vaccines -- Bacterial Vectors -- Viral Vectors -- DNA and RNA Replicons -- Nano-Sized Vehicles for Gene Delivery -- Inorganic to Biomaterial - Past to Future -- Size Determines the Fate of Particles -- Conclusion -- References -- Chapter III Novel Delivery Strategies for DNA -- Abstract -- I. Introduction -- II. Optimization of Immunogenicity of DNA Vaccines -- 2.1. Choice of Targets and Expression Plasmid for DNA Vaccines -- 2.2. Selection of High Expression Plasmids for DNA Vaccines -- 2.3. Codon Optimization for Higher Gene Expression -- 2.4. Adjuvant Choice for DNA Vaccines -- III. DNA Delivery Strategies -- 3.1. Invasive Delivery -- 3.1.1. Needle Injection. ; 3.1.2. In Vivo Electroporation -- 3.1.3. Tattoo Gun Delivery -- 3.2. Non-Invasive Topical Delivery Method -- 3.2.1. Tape Stripping -- 3.2.2. Nanopatch Delivery -- 3.2.3. Nano-Particle Mediated Delivery -- 3.3. Viral-Mediated DNA Delivery Systems -- 3.4. Non-Viral Gene Delivery Systems -- 3.5. Novel Delivery Methods -- 3.5.1. Laser Mediated Delivery -- 3.5.2. Ultrasound Mediated Delivery System -- III. Future Directions -- References -- Chapter IV Recent Advances in DNA Vaccines -- Abstract -- Introduction -- DNA Vaccines X Traditional Vaccine Approaches -- Components of a DNA Vaccine -- How DNA Vaccines Work -- Delivery Methods -- Advantages X Limitations -- Strategies to Enhance Immunogenicity of DNA Vaccines -- Modifications of Plasmid Basic Design -- Delivery Methods -- Target to Dendritic Cells -- Improved Immunization Protocols -- Adjuvants -- Conclusion -- References -- Chapter V Co-Administration of Gamma Interferon Gene with DNA Vaccine Expressing Duck Hepatitis B Virus (DHBV) Proteins Enhances Therapeutic Efficacy of DNA-Based Immunization in Chronic Virus Carriers -- Abstract -- Introduction -- Materials and Methods -- Animals -- DNA Immunization -- Analysis of Viral DNA -- Analysis of Infectivity of Liver Extracts Collected from Resolved Ducks -- Histopathological and Immuno-Histochemical Analysis -- Statistical Analysis -- Results -- Decrease in Viremia following Co-Immunization with Cytokine Expressing Plasmids -- Enhancement of DHBV DNA clearance by Co-Immunization with IFN- expressing Plasmid -- Virological Analysis and Infectivity of Liver Samples Collected from Resolved Animals -- Adverse Effects of Therapy -- Conclusion -- Acknowledgments -- References -- Chapter VI The Role of DNA-IL-12 Vaccination in Eosinophilic Inflammation: A Review -- Abstract -- Basic DNA Vaccine Concepts -- Strategies for DNA Vaccine Administration. ; Structure and Function of Interleukin-12 -- IL-12 Therapy -- Eosinophilia and Asthma -- Impact of pcDNA-IL-12 Administration on Eosinophilia and Pulmonary Hyperreactivity in a Murine Model -- References -- Chapter VII Cured By DNA-Genetic Immunization in the Therapeutic Sector -- Abstract -- Introduction -- Modulation of the Immune System -- The Big Four - Cancer, HIV, Hepatitis and Tuberculosis -- Cancer -- HIV -- Hepatitis -- Tuberculosis -- Clinical Trials -- Safety Issues, Limitations and Disadvantages -- Conclusion -- References -- Chapter VIII DNA Vaccination against Herpesvirus -- Abstract -- Introduction -- Bovine Herpesvirus-1 -- DNA Vaccine against Bovine Herpesvirus-1 -- Route of Immunization -- Chemical Adjuvants -- Animal Response Following -- DNA Vaccination -- References -- Chapter IX DNA Vaccination: Progress and Challenges -- Abstract -- Abbreviations -- Introduction -- Advantages of DNA Vaccines -- Limitations of DNA Vaccines -- Conclusion -- Acknowledgments -- References -- Index.
• Titolo autorizzato: DNA vaccines
• ISBN: 1-62081-045-X
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910825809303321
• Lo trovi qui: Univ. Federico II
• Serie: Immunology and immune system disorders.