Hydrogen sulfide : chemical biology basics, detection methods, therapeutic applications, and case studies / / edited by Michael D. Pluth

• Pubblicazione: Hoboken, New Jersey : , : John Wiley & Sons, Incorporated, , [2022]; ©2022
• Descrizione fisica: 1 online resource (645 pages)
• Disciplina: 615.91
• Soggetto topico: Hydrogen - Thermal properties
• Persona (resp. second.): PluthMichael D.
• Note generali: Includes index.
• Nota di contenuto: Intro -- Table of Contents -- Title Page -- Copyright -- Preface -- List of Contributors -- 1 Fundamental and Biologically Relevant Chemistry of H2S and Related Species -- List of Abbreviations -- 1.1 Introduction -- 1.2 The Chemical Biology of H2S -- 1.3 H2S Reactions with Other Sulfur Species -- 1.4 The Biochemical Utility of RSSH -- 1.5 Summary/Conclusion -- References -- 2 Signaling by Hydrogen Sulfide (H2S) and Polysulfides (H2Sn) and the Interaction with Other Signaling Pathways -- List of Abbreviations -- 2.1 Introduction -- 2.2 Determination of the Endogenous Concentrations of H2S -- 2.3 H2S and H2Sn as Signaling Molecules -- 2.4 Crosstalk Between H2S and NO -- 2.5 Cytoprotective Effect of H2S, H2Sn, and H2SO3 -- 2.6 Energy Formation in Mitochondria with H2S -- 2.7 S‐Sulfurated Proteins and Bound Sulfane Sulfur in Cells -- 2.8 Regulating the Activity of Target Proteins by H2S and H2Sn -- 2.9 Perspectives -- Acknowledgments -- Author Disclosure Statement -- References -- 3 Persulfides and Their Reactions in Biological Contexts -- List of Abbreviations -- 3.1 Persulfides Are Key Intermediates in Sulfur Metabolism and Signaling -- 3.2 Persulfides Are Formed in Biological Systems through Different Pathways -- 3.3 Persulfides Are More Acidic Than Thiols -- 3.4 Persulfides Are Stronger Nucleophiles Than Thiols -- 3.5 Persulfidation Protects Against Irreversible Oxidation -- 3.6 Persulfides Interact with Metals and Metalloproteins -- 3.7 Persulfides Have Electrophilic Character in Both Sulfur Atoms -- 3.8 Persulfides Are Efficient One‐Electron Reductants -- 3.9 Concluding Remarks -- References -- Notes -- 4 Hydrogen Sulfide, Reactive Nitrogen Species, and "The Joy of the Experimental Play*" -- 4.1 Introduction -- 4.2 Basic Physicochemical Properties of Nitric Oxide and Its Biological Relevant Metabolites. ; 4.3 Basic Physicochemical Properties of H2S and Its Biological Relevant Metabolites -- 4.4 Inorganic Sulfur-Nitrogen Compounds -- 4.5 Putative Biological Relevance of the NO/H2S Chemical Interaction -- 4.6 Summary and Conclusions -- Acknowledgment -- References -- Note -- 5 H2S and Bioinorganic Metal Complexes -- List of Abbreviations -- 5.1 Introduction -- 5.2 Basic Ligative Properties of H2S/HS− -- 5.3 H2S and Heme Iron -- 5.4 H2S and Nonheme Iron -- 5.5 H2S Chemistry with Other Metals -- 5.6 H2S Sensing with Transition Metal Complexes -- 5.7 Summary -- Acknowledgments -- References -- 6 Measurement of Hydrogen Sulfide Metabolites Using the Monobromobimane Method -- List of Abbreviations -- 6.1 Introduction -- 6.2 Monobromobimane: An Optimal Method of Bioavailable Sulfur Detection -- 6.3 Procedures -- 6.4 Caveats and Considerations -- Acknowledgment -- Disclosures -- References -- 7 Fluorescent Probes for H2S Detection: Cyclization‐Based Approaches -- List of Abbreviations -- 7.1 Introduction -- 7.2 General Design of Nucleophilic Reaction‐Cyclization Based Fluorescent Probes -- 7.3 Conclusions and Perspectives -- Acknowledgments -- References -- 8 Fluorescent Probes for H2S Detection: Electrophile‐Based Approaches -- 8.1 Introduction -- 8.2 Selected Probes Based on Different Reaction Types -- 8.3 Conclusion and Future Prospects -- References -- 9 Fluorescent Probes for H2S Detection: Metal‐Based Approaches -- 9.1 Introduction -- 9.2 Metal Displacement Approach -- 9.3 Coordinative‐Based Approach -- 9.4 H2S‐Mediated Reduction of the Metal Center -- 9.5 Conclusions and Future Outlooks -- References -- 10 H2S Release from P S and Se-S Motifs -- List of Abbreviations -- 10.1 Introduction -- 10.2 H2S Release from P S Motifs -- 10.3 H2S Release from Se-S Motifs -- 10.4 Acyl Selenylsulfides: Structural Modifications and Activity of Analogs. ; 10.5 Conclusions -- References -- 11 Hydrogen Sulfide: The Hidden Player of Isothiocyanates Pharmacology -- 11.1 Organic Isothiocyanates as H2S‐Donors -- 11.2 Organic ITCs and Cardiovascular System -- 11.3 Chemopreventive Properties of ITCs -- 11.4 Anti‐nociceptive Effects of ITCs -- 11.5 Anti‐inflammatory and Antiviral Effects of ITCs -- 11.6 Conclusion -- Acknowledgment -- References -- 12 Persulfide Prodrugs -- List of Abbreviations -- 12.1 Introduction -- 12.2 Persulfide Prodrugs -- 12.3 Challenges in Persulfide Prodrug Design and Potential Therapeutic Applications -- References -- 13 COS‐Based H2S Donors -- 13.1 Introduction -- 13.2 Properties of COS -- 13.3 COS‐Based H2S Delivery -- 13.4 Conclusions and Outlook -- Acknowledgments -- References -- 14 Light‐Activatable H2S Donors -- 14.1 Introduction -- 14.2 Photophysical and Photochemical Concepts -- 14.3 Phototherapeutic Window -- 14.4 Light Sources -- 14.5 (Photo)Physical Properties of H2S -- 14.6 Mechanisms and Examples of H2S Photorelease -- 14.7 Outlook -- Acknowledgment -- References -- 15 Macromolecular and Supramolecular Approaches for H2S Delivery -- List of Abbreviations -- 15.1 Introduction -- 15.2 H2S‐Donating Linear Polymers -- 15.3 H2S Delivery from Branched and Graft Polymer Topologies -- 15.4 Polymer Micelles for H2S Delivery -- 15.5 Polymer Networks for Localized H2S Delivery -- 15.6 Other Polymeric Systems for the Encapsulation of H2S Donors -- 15.7 H2S Release via Supramolecular Systems -- 15.8 Conclusions and Future Perspectives -- References -- 16 H2S and Hypertension -- List of Abbreviations -- 16.1 Hypertension, Vascular Homeostasis and Mediators Controlling Blood Pressure -- 16.2 Generation of H2S in the Cardiovascular System -- 16.3 Relevance of H2S in Hypertension -- 16.4 Conclusions -- References -- 17 H2S Supplementation and Augmentation: Approaches for Healthy Aging. ; List of Abbreviations -- 17.1 Introduction and Background -- 17.2 Hydrogen Sulfide Metabolism and Applications in Non‐mammalian Aging -- 17.3 Hydrogen Sulfide Metabolism and Applications in Nonhuman Mammalian Aging -- 17.4 Hydrogen Sulfide Metabolism and Applications in Human Aging and Aging‐Related Disorders -- 17.5 Conclusions and Summary -- Acknowledgments -- References -- 18 Aberrant Hydrogen Sulfide Signaling in Alzheimer's Disease -- List of Abbreviations -- 18.1 Introduction -- 18.2 Alzheimer's Disease -- 18.3 Therapeutic Avenues -- Acknowledgments -- References -- 19 Multifaceted Actions of Hydrogen Sulfide in the Kidney -- List of Abbreviations -- 19.1 Introduction -- 19.2 H2S Synthesis in the Kidney -- 19.3 H2S and Kidney Physiology -- 19.4 H2S and the Aging Kidney -- 19.5 H2S and Acute Kidney Injury (AKI) -- 19.6 H2S in Chronic Kidney Disease (CKD) -- 19.7 H2S and Preeclampsia -- 19.8 H2S and Genitourinary Cancers -- 19.9 Conclusion and Future Directions -- Acknowledgments -- References -- Index -- End User License Agreement.
• Titolo autorizzato: Hydrogen sulfide
• ISBN: 1-119-79990-2; 1-119-79988-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910642709203321
• Lo trovi qui: Univ. Federico II
• Serie: Wiley Series in Drug Discovery and Development Ser.