Exercise metabolism / / Glenn McConell, editor

• Pubblicazione: Cham, Switzerland : , : Springer, , [2022]; ©2022
• Descrizione fisica: 1 online resource (405 pages) : illustrations
• Disciplina: 612.39
• Soggetto topico: Energy metabolism; Exercise - Physiological aspects
• Persona (resp. second.): McConellGlenn
• Nota di bibliografia: Includes bibliographical references.
• Nota di contenuto: Intro -- Preface -- Acknowledgements -- Contents -- Chapter 1: A Brief History of Exercise Metabolism -- 1.1 Introduction -- 1.2 Exercise Metabolism, Late Eighteenth Century to the 1860s: Protein Reigns Supreme -- 1.3 Exercise Metabolism, 1860s to World War II: Carbohydrate Is King -- 1.4 Exercise Metabolism, World War II to the Late 1960s: Lipids Have Their Heyday -- 1.5 Exercise Metabolism, Late 1960s to ca. 1990: Carbohydrates Mount a Comeback -- 1.6 Exercise Metabolism, ca. 1990 to Present: Détente Prevails -- 1.6.1 Endurance Training -- 1.6.2 Aging -- 1.6.3 Sex -- 1.6.4 Obesity and Type 2 Diabetes -- 1.7 Summary -- References -- Chapter 2: Overview of Exercise Metabolism -- References -- Chapter 3: Exercise: Thermodynamic and Bioenergetic Principles -- 3.1 Introduction -- 3.2 Thermodynamic Principles -- 3.3 Nonequilibrium Thermodynamics: Using Natural Forces to Establish Displacement from Equilibrium -- 3.4 How Are Bioenergetic Systems Engaged by Exercise? -- 3.5 Factors Affecting Mitochondrial Bioenergetic Efficiency -- 3.6 ROS Production as a Determinant of Bioenergetic Efficiency -- 3.7 Protein-Mediated Proton Leak -- 3.7.1 Uncoupling Proteins (UCPs) -- 3.7.2 ANT1 -- 3.7.3 Other SLC25 Family Proteins -- 3.8 Posttranslational Regulation of Mitochondrial Function -- 3.9 The Mitochondrial Network -- 3.10 The Inner Mitochondrial Membrane (IMM) -- 3.11 Mitochondrial Phospholipids -- 3.12 Supercomplex Formation -- 3.13 The Redox Circuit -- 3.14 Conclusion -- References -- Chapter 4: Anaerobic Metabolism During Exercise -- 4.1 Introduction -- 4.2 Aerobic and Anaerobic Metabolism Work Together -- 4.3 Brief History of Anaerobic Metabolism Investigations -- 4.4 Regulation of Anaerobic Energy Provision During High-Intensity, Short-Term Exercise -- 4.5 Intermittent High-Intensity Exercise. ; 4.6 Other Methods to Estimate Anaerobic Energy Contributions -- 4.7 Sprint Training and Creatine Supplementation -- 4.8 Summary -- References -- Chapter 5: Exercise and Muscle Glycogen Metabolism -- 5.1 Introduction -- 5.2 Glycogen Storage and Regulation -- 5.2.1 Biochemistry of the Glycogen Particle and Its Turnover -- 5.2.2 Measurement of Muscle Glycogen -- 5.2.3 Inter-fiber Variability and Subcellular Differences -- 5.3 Utilization of Glycogen During Exercise -- 5.3.1 Duration and Intensity -- 5.3.2 Substrate Availability -- 5.3.2.1 Increased Muscle Glycogen Stores and Glycogen Use -- 5.3.2.2 Increased Lipid Availability and Glycogen Sparing -- 5.3.2.3 CHO Supplementation During Exercise and Glycogen Sparing -- 5.3.3 Training Status -- 5.3.4 Exercise Mode -- 5.3.4.1 Running vs. Cycling -- 5.3.4.2 Resistance Exercise -- 5.3.5 Lower vs Upper Body -- 5.3.6 Temperature -- 5.3.7 Altitude -- 5.3.8 Sex Differences -- 5.3.9 Subcellular Compartmentalization -- 5.4 Glycogen Depletion and Fatigue -- 5.4.1 Correlations with Performance -- 5.4.1.1 Prolonged Exercise (60-180 Min) -- 5.4.1.2 Short-Term Exercise (< -- 15 Min) -- 5.4.1.3 Resistance Exercise -- 5.4.2 A Causal Link to Fatigue? -- 5.4.2.1 SR Ca2+ Regulation -- 5.4.2.2 Muscle Excitability and Na, K-Pump -- 5.4.2.3 Insights from McArdle Patients -- 5.5 Muscle Glycogen as a Regulator of Skeletal Muscle Training Adaptations -- 5.6 Concluding Remarks and Future Directions -- References -- Chapter 6: Exercise-Regulated Skeletal Muscle Glucose Uptake -- 6.1 Muscle Glucose Uptake During Exercise -- 6.2 Glucose Delivery -- 6.3 Glucose Transport Out of the Capillaries -- 6.4 Glucose Transport into the Muscle Fibers -- 6.5 Glucose Metabolism -- 6.6 Evidence Linking Glucose Transport to GLUT4 in Transgenic Mice -- 6.7 Exercise-Activated Signals Regulating Glucose Uptake -- 6.8 Ca2+ Signaling. ; 6.9 Mechanical Stress -- 6.10 Metabolic Stress and AMPK -- 6.11 Nitric Oxide -- 6.12 Mechanistic Target of Rapamycin Complex 2 -- 6.13 Conclusion -- References -- Chapter 7: Adipose Tissue Lipid Metabolism During Exercise -- 7.1 Introduction -- 7.2 Contribution of Fat to Energy Expenditure During Exercise -- 7.3 Mobilization of Fatty Acids from Adipose Tissue During Exercise -- 7.3.1 Lipolytic Rate During Exercise -- 7.3.2 Regulation of Lipolysis -- 7.3.2.1 Lipolytic Proteins -- 7.3.2.2 Adrenergic Regulation of Lipolysis During Exercise -- 7.3.2.3 Insulin Regulation of Lipolysis -- 7.3.2.4 Alternative Lipolytic Regulators -- 7.4 Regional Differences in Adipose Tissue Metabolism and Fat Mobilization -- 7.5 Alternative Sources of Fat Used During Exercise -- 7.6 Endurance Training Effects on Fat Metabolism -- 7.7 Sex Differences in Adipose Metabolism During Exercise -- 7.8 Adipose Tissue-Derived ``Adipokines´´ -- 7.9 Summary and Conclusions -- References -- Chapter 8: Regulation of Fatty Acid Oxidation in Skeletal Muscle During Exercise: Effect of Obesity -- 8.1 Introduction -- 8.2 Fatty Acids as Energy Fuel in Skeletal Muscle -- 8.2.1 Albumin-Bound Plasma FA -- 8.2.2 Regulation of Fatty Acid Uptake into Skeletal Muscle -- 8.3 The Intracellular FA Source -- 8.4 Mitochondrial Regulation of FA Oxidation During Exercise -- 8.4.1 CPT, Carnitine, and Mitochondrial Fatty Acid Import During Exercise -- 8.5 Summarizing Remarks on the Regulation of FA Oxidation in Skeletal Muscle During Exercise -- 8.6 Are There Impairments in Fatty Acid Oxidation in Skeletal Muscle with Obesity? -- 8.7 Exercise: Do the Alterations in Fatty Acid Oxidation in Skeletal Muscle with Obesity Alter Substrate Utilization During Ex... -- 8.8 Exercise Training: An Effective Intervention for the Reduction in Fatty Acid Oxidation in the Skeletal Muscle of Individua. ; 8.9 Summarizing Remarks on the Role of Obesity in Regulation of FA Oxidation During Rest and Exercise and the Counter-regulato... -- References -- Chapter 9: Skeletal Muscle Protein Metabolism During Exercise -- 9.1 General Introduction -- 9.2 Muscle Protein Synthesis and Breakdown -- 9.3 The Influence of Exercise -- 9.4 The Influence of Nutrition -- 9.4.1 Amino Acids -- 9.5 The Measurement of Protein Turnover -- 9.6 The Concept of Exercise Specificity -- 9.6.1 Aerobic Exercise -- 9.6.1.1 The Effect of Aerobic Training Status on Skeletal Muscle Protein Metabolism During Exercise -- 9.6.1.2 Aerobic Exercise and Muscle Protein Turnover -- 9.6.2 Strength Exercise -- 9.6.2.1 The Effect of Strength Exercise Training Status on Skeletal Muscle Protein Metabolism -- 9.6.2.2 Molecular Regulation of Skeletal Muscle Protein Synthesis in Response to Strength Exercise -- 9.6.3 Concurrent Exercise and Muscle Protein Metabolism -- 9.6.3.1 Concurrent Exercise Training and Potential Interference -- 9.6.3.2 Molecular Regulation of Skeletal Muscle Protein Synthesis in Response to Concurrent Exercise -- 9.7 Conclusion -- References -- Chapter 10: The Effect of Training on Skeletal Muscle and Exercise Metabolism -- 10.1 Introduction -- 10.2 The Nature of the Exercise Stimulus: Endurance, Strength, and Sprint Training -- 10.3 Overview of Skeletal Muscle Metabolic Regulation During Exercise -- 10.4 Molecular Basis of Training-Induced Changes in Skeletal Muscle -- 10.5 Skeletal Muscle Responses to Training -- 10.6 Endurance Training -- 10.6.1 Acute Metabolic Response -- 10.6.2 Molecular Basis of Adaptations -- 10.6.3 Metabolic Characteristics and Responses in the Trained State -- 10.7 Strength Training -- 10.7.1 Acute Metabolic Response -- 10.7.2 Molecular Basis of Adaptations -- 10.7.3 Metabolic Characteristics and Exercise Responses in the Trained State. ; 10.8 Sprint Training -- 10.8.1 Acute Metabolic Response -- 10.8.2 Molecular Basis of Adaptations -- 10.8.3 Metabolic Characteristics and Exercise Responses in the Trained State -- 10.9 Conclusion -- References -- Chapter 11: Role and Regulation of Hepatic Metabolism During Exercise -- 11.1 Metabolic Demands of Exercise on the Liver -- 11.2 Endocrine Regulation of the Liver During Exercise -- 11.3 Liver Glycogen Repletion After Exercise -- 11.4 Hepatic Adaptation to Exercise Training -- References -- Chapter 12: Influence of Exercise on Cardiac Metabolism and Resilience -- 12.1 Introduction -- 12.2 Integrated Cardiac Responses to Exercise -- 12.2.1 Acute Changes in Cardiac Physiology -- 12.2.2 Cardiac Energy Metabolism During Exercise -- 12.2.3 Chronic Effects of Exercise on the Heart -- 12.2.3.1 Metabolic Adaptation of the Heart to Chronic Exercise Regimens -- 12.2.4 Exercise-Induced Cardioprotection: A Clinical Application of Metabolic Adaptations in the Exercised Heart -- 12.3 Summary -- References -- Chapter 13: Metabolism in the Brain During Exercise in Humans -- 13.1 Background -- 13.2 Cerebral Metabolism and Fuel Utilization at Rest -- 13.2.1 Summary -- 13.3 Regulation of Cerebral Metabolism During Exercise -- 13.3.1 Summary -- 13.3.2 Techniques to Assess Cerebral Metabolism During Dynamic Exercise in Humans -- 13.4 Cerebral Substrate Oxidation During Exercise -- 13.4.1 Incremental Versus Steady-State Exercise and Cerebral Metabolism -- 13.4.2 Cerebral Metabolic Rate of Oxygen During Exercise -- 13.4.3 Cerebral Metabolic Rate of Glucose During Exercise -- 13.4.4 Cerebral Metabolic Rate of Lactate During Exercise -- 13.4.5 Ketone Utilization During Exercise? -- 13.4.6 Summary -- 13.5 Summary -- References -- Chapter 14: Effects of Age on Exercise Metabolism -- 14.1 Introduction -- 14.2 Metabolic Response to Resistance Exercise. ; 14.3 Metabolic Response to Endurance Exercise.
• Titolo autorizzato: Exercise Metabolism
• ISBN: 9783030943059; 9783030943042
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910585772103321
• Lo trovi qui: Univ. Federico II
• Serie: Physiology in health and disease.