Dietary phytochemicals : a source of novel bioactive compounds for the treatment of obesity, cancer and diabetes / / Chukwuebuka Egbuna, Sadia Hassan, editors

• Pubblicazione: Cham, Switzerland : , : Springer, , [2021]; ℗♭2021
• Descrizione fisica: 1 online resource (262 pages)
• Disciplina: 615.321
• Soggetto topico: Phytochemicals - Health aspects; Fitoquímica; Nutrició; Biotransformació (Metabolisme); Càncer; Obesitat; Diabetis
• Soggetto genere / forma: Llibres electrònics
• Persona (resp. second.): EgbunaChukwuebuka; HassanSadia
• Nota di contenuto: Intro -- Preface -- Contents -- Etiology of Obesity, Cancer, and Diabetes -- 1 Introduction -- 2 Obesity -- 2.1 Etiology of Obesity -- 2.2 Biological Factors -- 2.2.1 Genetics -- Monogenic Obesity -- Syndromic Obesity -- Polygenic Obesity -- 2.2.2 Brain-gut Axis -- 2.2.3 Prenatal Determinants -- 2.2.4 Pregnancy -- 2.2.5 Menopause -- 2.2.6 Physical Disability -- 2.2.7 Gut Microbiome -- 2.3 Environmental Factors -- 2.3.1 Obesogenic Environment -- 2.3.2 Socio-Economic Factors -- 2.3.3 Environmental Chemicals and Obesity -- 2.4 Behavioral Factors -- 2.4.1 Increased Calorie Intake and Eating Habits -- 2.4.2 Sedentary Lifestyle and Less Physical Activity -- 2.4.3 Insufficient Sleep -- 2.4.4 Quitting Smoking -- 3 Cancer -- 3.1 Major Types of Cancer -- 3.2 Causes of Cancer -- 3.2.1 Diet and Physical Activity -- 3.2.2 Use of Addictive Substances -- 3.2.3 Sex and Reproductive Health -- 3.2.4 Environmental Factors -- 3.2.5 Genetics -- 4 Diabetes Mellitus -- 4.1 Causes of Type 1 Diabetes Mellitus -- 4.1.1 Genetic Susceptibility Factors -- 4.1.2 Virus-Related Contagions -- 4.1.3 Role of Environment -- 4.2 Etiology of Type 2 Diabetes Mellitus -- 5 Conclusion -- References -- Pathophysiology of Obesity and Diabetes -- 1 Introduction -- 2 Obesity and Body Mass Index -- 3 Pathophysiology of Obesity -- 3.1 Development of Fat Cells -- 3.2 Fat Cell Metabolism -- 3.3 Oxidative Stress -- 3.4 Weight Stigma -- 4 Role of Different Factors in the Pathophysiology of Obesity -- 4.1 Pathophysiology of Obesity and the Role of Autonomic Nervous System -- 4.2 Osteopontin and Obesity -- 4.3 Obesity and Renal Disease -- 5 Maternal Obesity -- 6 Potential Role of Gut Inflammation in Disease Development -- 7 Childhood Obesity -- 8 Pathophysiology of Diabetes -- 8.1 Etiology of Diabetes -- 8.2 Role of Genetics in Development of T2DM. ; 8.3 Role of Environmental Determinants in the Development of T2DM -- 8.4 Insulin Resistance -- 8.5 The Role of Glucagon -- 8.6 Somatostatin -- 9 Conclusion -- References -- Pathophysiology of Obesity and Cancer: Drugs and Signaling Targets -- 1 Introduction -- 2 Pathophysiology of Obesity and Cancer -- 3 History of Anti-obesity Drugs -- 4 How to Treat Obesity? -- 5 Different Targets in Brain to Treat Obesity -- 5.1 Serotoninergic System -- 5.2 Noradrenergic System -- 5.3 Dopaminergic System -- 6 Link Between Obesity and Cancer -- 7 Drugs Targeting Cancer Cells -- 8 Drugs Targeting the Tumor Microenvironment's Cellular and Molecular Components -- 9 Changes in the Pharmacokinetics -- 10 Changes in Microbiota -- 11 Combination Therapy -- 12 Conclusion -- References -- Peptides Involved in Body Weight Regulation -- 1 Introduction -- 2 Appetite, Food Intake, and Obesity -- 3 Peptides and Body Weight -- 3.1 Effects of Hormonal Peptides -- 3.1.1 Orexigenic Peptides -- 3.1.2 Anorexigenic Peptides -- 3.1.3 Effects of Hypothalamic Peptides -- 3.2 Bioactive Peptides and Body Weight -- 4 Conclusion -- References -- Insulin Resistance: A Link Between Obesity and Cancer -- 1 Introduction -- 2 Obesity and Cancer -- 3 Diabetes and Cancer -- 4 Obesity and Diabetes -- 5 Mechanism Linking Insulin Resistance to Obesity and Cancer -- 6 Drugs to Treat Insulin Resistance -- 6.1 Metformin -- 6.2 Thiazolidinediones -- 6.3 Insulin Analogues -- 7 Challenges in Prevention and Treatment -- 8 Conclusion -- References -- Role of Cytoskeletal Protein, Actin in Various Diseases -- 1 Introduction -- 2 Microfilaments or Actin Filaments -- 2.1 Role in Cancer Metastasis and Tumor Angiogenesis -- 2.2 Role in Cytokinesis -- 2.3 Role in Cellular Signaling and Transport -- 2.4 Role in Immunodeficiency -- 2.5 Role in Fertilization of Eggs -- 2.6 Role in Neuronal Plasticity. ; 2.7 Role in Neurodegenerative Diseases -- 2.8 Role in Epigenetic Control -- 2.9 Role in Muscle Contraction -- 3 Conclusions -- References -- Diabetes Mellitus and it Management with Plant-Based Therapy -- 1 Introduction -- 2 Classification of Diabetes -- 2.1 Type I Diabetes Mellitus (T1DM) -- 2.2 Type II Diabetes Mellitus (T2DM) -- 2.3 Gestational DM (GDM) -- 3 Risk Factors of Diabetes -- 4 Pathophysiology -- 5 Screening and Diagnosis -- 6 Management -- 6.1 Through Lifestyle and Diet Modification -- 6.2 Pharmacological Agents -- 6.3 Plant Based Therapy -- 6.3.1 Mechanisms Underlying Herbal Anti-Diabetic Therapies -- 6.3.2 Classification of Plant-Based Anti-Diabetics -- 7 Conclusion -- References -- Fruits and Vegetables as Sources of Functional Phytochemicals for the Prevention and Management of Obesity, Diabetes, and Cancer -- 1 Introduction -- 2 Classification of Phytochemicals -- 2.1 Polyphenols -- 2.2 Terpenoids -- 2.3 Thiols -- 3 Health Benefits and Nutritional Value of Certain Fruits and Vegetables -- 3.1 Tomatoes -- 3.2 Grapes and Berries -- 3.3 Nuts -- 3.4 Citrus -- 3.5 Brassica Vegetables -- 3.6 Mushrooms -- 3.7 Kiwi -- 3.8 Cladodes -- 3.9 Carrots -- 3.10 Potatoes -- 3.11 Onion and Garlic -- 4 The Effect of Consuming Fruits and Vegetables on Some Diseases -- 4.1 Cancer -- 4.2 Obesity -- 4.3 Diabetes -- 5 Conclusion -- References -- Spices for Diabetes, Cancer and Obesity Treatment -- 1 Introduction -- 2 Anti-diabetic Effect of Spices -- 2.1 Fenugreek -- 2.2 Cinnamon -- 2.3 Garlic and Onion -- 2.4 Turmeric -- 2.5 Cumin Seeds -- 2.6 Ginger -- 3 Spices in the Treatment of Cancer -- 3.1 Basil -- 3.2 Caraway -- 3.3 Cardamom -- 3.4 Rosemary -- 3.5 Cumin -- 3.6 Turmeric -- 3.7 Garlic -- 3.8 Black Pepper -- 3.9 Red Chili -- 3.10 Ginger -- 3.11 Saffron -- 4 Spices in the Treatment of Obesity -- 4.1 Ginger -- 4.2 Turmeric -- 4.3 Garlic. ; 4.4 Red Pepper -- 5 Conclusion -- References -- MicroRNAs as Targets of Dietary Phytochemicals in Obesity and Cancer -- 1 Introduction -- 2 Phytochemical Modulated miRNAs and Its Role in Obesity -- 3 MicroRNAs as Phytochemicals Targets in Carcinogenesis -- 4 Dietary Phytochemicals and miRNA -- 4.1 Resveratrol -- 4.2 Genistein -- 4.3 Conjugated Linoleic Acids -- 4.4 Cinnamic Acid and Cinnamaldehyde -- 4.5 Ajoene -- 4.6 Curcumin -- 4.7 Epigallocatechin-3-Gallate -- 4.8 Quercetin -- 5 Conclusion -- References -- Natural Phenolic Compounds as Anti-obesity and Anti-cardiovascular Disease Agent -- 1 Introduction -- 2 Effects of Natural Phenolic Compounds on Oil and Fat Metabolism -- 3 Binding Bile Salt to Inhibit Emulsification of Lipids -- 3.1 In Vitro Studies -- 4 Pancreatic Lipase Inhibition -- 4.1 In Vitro Studies -- 4.2 In Silico Modeling Studies -- 4.3 Increase Fecal Lipid Excretion -- 4.4 Animal Models -- 4.5 Clinical Research -- 5 Gut Microbiota as Potential Targets -- 6 Reduction of Lipogenesis and Inflammation in Adipose Tissue and Liver -- 6.1 In Vitro Studies by Cell Models -- 6.2 Animal Models -- 7 Suppression of Lipogenic Enzyme Fatty Acid Synthase (FAS) in Cell -- 7.1 Cell Model -- 7.2 Animal Models -- 8 Increase of Lipolysis in Cell -- 9 Inhibition of Adipocyte Differentiation and Growth -- 10 Anti-atherosclerosis by Natural Phenolic Compounds -- 11 Conclusion -- References -- Harnessing the Potential of Phytochemicals for Breast Cancer Treatment -- 1 Introduction -- 2 Statistical Evidence Including the Indian Scenario -- 3 Current Treatments Strategies for Breast Cancer -- 3.1 Chemotherapy -- 3.2 Surgery -- 3.3 Gene Therapy -- 3.4 Oncogenes Inactivation -- 3.5 Augmentation of Tumor Suppresser Genes -- 3.5.1 BRCA1 and BRCA2 -- 3.5.2 Androgen Receptor -- 3.5.3 Immunomodulation -- 3.5.4 Endocrine (Antihormonal) Treatment. ; 3.5.5 Inclination Towards Phytochemicals -- 4 Phytochemicals for Breast Cancer Therapy -- 4.1 Plumbagin -- 4.2 Apigenin -- 4.3 Isothiocyanate -- 4.4 Quercetin -- 4.5 Curcumin -- 4.6 Catechins -- 4.7 Lycopene -- 4.8 Hesperidin -- 4.9 Anthocyanin -- 4.10 Colchicine Alkaloid -- 4.11 Polyphyllin D -- 4.12 Genistein -- 4.13 Resveratrol -- 4.14 Berberine -- 5 Pharmaceutical Compounding of Phytochemicals -- 6 Conclusion -- References -- Index.
• Titolo autorizzato: Dietary phytochemicals
• ISBN: 3-030-72999-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910495214003321
• Lo trovi qui: Univ. Federico II