Neglected tropical diseases and phytochemicals in drug discovery / / edited by Chukwuebuka Egbuna, Muhammad Akram, Jonathan Chinenye Ifemeje

• Pubblicazione: Hoboken, New Jersey : , : John Wiley & Sons, Inc., , [2022]; ©2022
• Descrizione fisica: 1 online resource (624 pages)
• Disciplina: 616.9883
• Soggetto topico: Tropical medicine; Phytochemicals - Therapeutic use
• Persona (resp. second.): IfemejeJonathan Chinenye; AkramMuhammad <1980->; EgbunaChukwuebuka
• Nota di contenuto: Cover -- Title Page -- Copyright Page -- Contents -- List of Contributors -- Preface -- Part I Introduction to Neglected Tropical Diseases -- Chapter 1 Epidemiology of Neglected Tropical Diseases -- List of Abbreviations -- 1.1 Introduction -- 1.2 Protozoan Infections -- 1.2.1 Human African Trypanosomiasis -- 1.2.2 Chagas Disease (American Trypanosomiasis) -- 1.2.3 Leishmaniasis -- 1.2.4 Amoebiasis -- 1.3 Helminth Infections -- 1.3.1 Soil-Transmitted Helminthiasis Infections -- 1.3.2 Schistosomiasis -- 1.3.3 Echinococcosis -- 1.3.4 Lymphatic Filariasis -- 1.3.5 Onchocerciasis ("River Blindness") -- 1.3.6 Foodborne Trematodiases -- 1.3.7 Dracunculiasis (Also Called Guinea Worm Disease) -- 1.4 Bacterial Infections -- 1.4.1 Yaws -- 1.4.2 Trachoma -- 1.4.3 Leprosy -- 1.4.4 Buruli Ulcer -- 1.5 Viral Infections -- 1.5.1 Rabies -- 1.5.2 Dengue -- 1.5.3 Chikungunya -- 1.6 Fungal and Ectoparasitic Infections -- 1.6.1 Chromoblastomycosis, Mycetoma/Eumycetoma, and Other Deep Mycoses -- 1.6.2 Scabies -- 1.6.3 Myiasis -- 1.7 Future Direction -- 1.8 Conclusion -- Acknowledgments -- References -- Chapter 2 Neglected Tropical Diseases, Phytochemicals, Protein Targets, and Mechanisms in Drug Discovery -- List of Abbreviations -- 2.1 Introduction -- 2.2 African Trypanosomiasis -- 2.2.1 Phytochemicals Against African Trypanosomiasis -- 2.3 Buruli Ulcer -- 2.3.1 Phytochemicals Against Buruli Ulcer -- 2.4 Chagas Disease -- 2.4.1 Phytochemicals Against Chagas Disease -- 2.5 Chikungunya -- 2.5.1 Phytochemicals Against Chikungunya -- 2.6 Dengue -- 2.6.1 Phytochemicals Against Dengue -- 2.7 Leishmaniasis -- 2.7.1 Phytochemicals Against Leishmaniasis -- 2.8 Leprosy -- 2.8.1 Indeterminate Leprosy -- 2.8.2 Phytochemicals Against Leprosy -- 2.9 Lymphatic Filariasis -- 2.9.1 Phytochemicals Against Lymphatic Filariasis -- 2.10 Mycetoma -- 2.10.1 Phytochemicals Against Mycetoma. ; 2.11 Onchocerciasis -- 2.11.1 Phytochemicals Against Onchocerciasis -- 2.12 Rabies -- 2.12.1 Phytochemicals Against Rabies -- 2.13 Scabies -- 2.13.1 Phytochemicals Against Scabies -- 2.14 Schistosomiasis -- 2.14.1 Phytochemicals Against Schistosomiasis -- 2.15 Conclusion -- References -- Chapter 3 Novel Bioactive Lead Compounds for Drug Discovery Against Neglected Tropical Diseases, Leishmaniasis, Lymphatic Filariasis, Trypanosomiasis (African Sleeping Sickness and Chagas Disease), and Schistosomiasis -- List of Abbreviations/Definitions -- 3.1 Introduction -- 3.2 Prevalence of Neglected Tropical Diseases -- 3.2.1 Leishmaniasis -- 3.2.2 Lymphatic Filariasis -- 3.2.3 Trypanosomiasis -- 3.2.3.1 African Trypanosomiasis (African Sleeping Sickness) -- 3.2.3.2 American Trypanosomiasis (Chagas Disease) -- 3.2.4 Schistosomiasis -- 3.3 Novel, Economical, and Efficacious Therapeutics from Medicinal Plants Against NTDs -- 3.3.1 Phytochemicals Effective Against Leishmania Parasite -- 3.3.2 Plants and Phytochemicals Effective Against Filarial Parasite -- 3.3.3 Plants and Phytochemicals Effective Against Trypanosomasis -- 3.3.4 Plants and Phytochemicals Effective Against Schistosomiasis -- 3.4 Future Prospects -- 3.5 Conclusion -- References -- Part II Protozoan Infections -- Chapter 4 Herbal, Nutritional, and Traditional Remedies for Giardiasis: Phytochemicals as Drug Candidates -- List of Abbreviations -- 4.1 Introduction -- 4.1.1 Epidemiology and Symptoms of Giardiasis -- 4.1.2 Life Cycle of G. duodenalis -- 4.1.3 Pathophysiology of Giardial Infection -- 4.1.4 Resistance to Allopathic Drug and Relevance of Herbal Medication -- 4.2 Plant-Based Dietary Supplements for Giardiasis Management -- 4.2.1 Oligosaccharide and Disaccharidase Supplementation -- 4.2.2 Dietary Fiber-Enriched Food -- 4.2.3 Agglutinin from Wheat -- 4.2.4 Vitamin and Mineral Supplements. ; 4.2.4.1 Vitamin A Supplementation -- 4.2.4.2 Compensation of Vitamin B12 -- 4.2.4.3 Zinc Status Management -- 4.2.5 Fermented Vegetables as Probiotic Source -- 4.2.6 Phenolic Compound Enriched Plant Food -- 4.3 Traditional Treatment of Giardiasis with Herbal Ethnomedicine -- 4.3.1 Hints of Antiprotozoal Medicines from Ancient Communities -- 4.3.2 Domestic Remedies and Alternative Medicine for Giardiasis -- 4.3.3 Applied Spectrum of Ethnopharmacology in Different Continents -- 4.3.3.1 Asian Medicinal Extracts -- 4.3.3.2 African Traditional Medicines -- 4.3.3.3 South American Ethnomedicine -- 4.4 Phytochemical Candidates for Advanced Giardicidal Drug Development -- 4.4.1 Terpenoids -- 4.4.2 Aromatic Ether -- 4.4.3 Alkaloids -- 4.4.4 Organo-sulfur Compounds -- 4.4.5 Lipids and Steroids -- 4.4.6 Phenolic Compounds -- 4.5 Future Prospects -- 4.5.1 Extension of Medicinal Compound Screening -- 4.5.2 Methodical Studies on Toxicology and Drug Adversity -- 4.5.3 Correlation of Herbal Drugs with Molecular Targets of Giardia -- 4.6 Summary, Prospects, and Conclusion -- References -- Chapter 5 Antiprotozoal Activity of Phytochemicals Against Entamoeba histolytica, the Causative Agent of Amoebiasis -- List of Abbreviations -- 5.1 Introduction -- 5.2 Life Cycle of Entamoeba histolytica -- 5.3 Diagnostic Techniques for Identification of E. histolytica -- 5.3.1 Intestinal Amoebiasis -- 5.3.1.1 Microscopy -- 5.3.1.2 Culture and Isoenzyme Analysis -- 5.3.1.3 Antigen Detection Test -- 5.3.1.4 Molecular-Based Test -- 5.3.1.5 Point-of-Care (POC) Test -- 5.4 Treatment of Amoebiasis -- 5.5 Alternative Treatment for Amoebiasis -- 5.6 Chemical Structure of Phytochemicals Effective Against E. histolytica -- 5.7 Possible Mechanisms of Phytochemicals as Antiamoebic -- 5.8 Future Projections -- 5.9 Conclusion -- References -- Chapter 6 Antileishmanial Potentials of Phytochemicals. ; 6.1 Introduction -- 6.2 Antileishmanial Activity of Propolis -- 6.2.1 Propolis from Turkey -- 6.2.2 Propolis from Brazil -- 6.2.3 Propolis from Portugal -- 6.2.4 Propolis from Cuba -- 6.2.5 Propolis from Ecuador -- 6.3 Antileishmanial Activity of Wild Mushrooms -- 6.4 Antileishmanial Activity of Medicinal Plants from Various Flora -- 6.4.1 Peruvian Flora -- 6.4.2 Ecuadorean Flora -- 6.4.3 Mexican Flora -- 6.4.4 Bolivian Flora -- 6.4.5 Iranian Flora -- 6.5 Antileishmanial Activity of Chemical Constituents -- 6.5.1 Alkaloids -- 6.5.2 Flavonoids -- 6.5.3 Terpenes -- 6.5.4 Glycoglycerolipids -- 6.5.5 Guttiferone A as a Lead Compound for Semisynthesis of Antileishmanial Molecules -- 6.6 Conclusion -- References -- Part III Helminth Infections -- Chapter 7 Prospects of Phytochemicals for the Treatment of Helminthiasis -- List of Abbreviations -- 7.1 Introduction -- 7.1.1 History -- 7.1.2 Prevalence -- 7.2 Molecular Characteristics of Soil-transmitted Helminthiasis -- 7.3 Clinical Features and Pathogenesis -- 7.4 Prevention -- 7.5 Treatment -- 7.6 Plants and Phytochemicals with Anthelmintic Activities -- 7.6.1 Modes of Action of Phytochemical Against the Soil-transmitted Helminthiasis -- 7.7 Scientific Reports of Medicinal Plants with Anthelmintic Properties -- 7.7.1 Adhatoda vasica -- 7.7.2 Allium sativum -- 7.7.3 Baliospermum montanum Muell -- 7.7.4 Butea monosperma -- 7.7.5 Calotropis procera -- 7.7.6 Carica papaya -- 7.7.7 Ficus benghalensis -- 7.7.8 Mimosa pudica -- 7.7.9 Punica granatum -- 7.7.10 Verbascum thapsus -- 7.7.11 Zingiber officinale -- 7.8 Future Prospects -- 7.9 Conclusion -- References -- Chapter 8 Efficacy of Phytochemicals of Medicinal Plants for the Treatment of Human Echinococcosis: Echinococcal Disease, Hydatidosis, or Hydatid Disease Drug Discovery -- List of Abbreviations -- 8.1 Introduction -- 8.2 Molecular Analysis. ; 8.3 Life Cycle of Echinococcosis -- 8.4 Previous Studies on the Positive Effects of Medicinal Plants and Phytochemicals -- 8.4.1 In vitro and in vivo Effect of Phytochemicals Against Echinococcus Infection -- 8.5 Synthetic Drugs Previously Used for Management of Echinococcosis Disease -- 8.6 Conclusion and Future Prospects -- References -- Chapter 9 Filaricidal Activity of Phytochemicals Against Lymphatic Filariasis -- List of Abbreviations -- 9.1 Introduction -- 9.2 Life Cycle of the Parasite -- 9.3 Synthetic Drugs Used for Treatment of Lymphatic Filariasis -- 9.4 Phytochemicals Used for the Treatment of Lymphatic Filariasis -- 9.4.1 Acacia auriculiformis -- 9.4.2 Aegle marmelos -- 9.4.3 Alnus nepalensis -- 9.4.4 Andrographis paniculata -- 9.4.5 Azadirachta indica -- 9.4.6 Bauhinia racemosa -- 9.4.7 Butea monosperma -- 9.4.8 Caesalpinia bonducella -- 9.4.9 Cardiospermum halicacabum -- 9.4.10 Centratherum anthelminticum -- 9.4.11 Excoecaria agallocha -- 9.4.12 Ficus racemosa -- 9.4.13 Glycyrrhiza glabra -- 9.4.14 Hibiscus sabdariffa -- 9.4.15 Lantana camara -- 9.4.16 Leucas cephalotes -- 9.4.17 Mallotus philippensis -- 9.4.18 Morinda citrifolia -- 9.4.19 Moringa oleifera -- 9.4.20 Plumbago indica -- 9.4.21 Pongamia pinnata -- 9.4.22 Psoralea corylifolia -- 9.4.23 Ricinus communis -- 9.4.24 Saxifraga stracheyion -- 9.4.25 Sphaeranthus indicus -- 9.4.26 Streblus asper -- 9.4.27 Trachyspermum ammi -- 9.4.28 Vitex negundo -- 9.4.29 Xylocarpus granatum -- 9.4.30 Zingiber officinale -- 9.5 Future Perspective -- 9.6 Conclusion -- References -- Chapter 10 Dracunculiasis (Guinea Worm Disease) and Phytochemicals in Drug Discovery -- List of Abbreviations -- 10.1 Introduction -- 10.2 Historical Insights of Dracunculiasis -- 10.3 Prevalence, Burden, and Distribution of Disease -- 10.4 Life Cycle, Pathogenesis, and Clinical Manifestations of Dracunculiasis. ; 10.5 Prevention and Eradication of Disease.
• Titolo autorizzato: Neglected tropical diseases and phytochemicals in drug discovery
• ISBN: 1-119-61715-4; 1-119-61714-6; 1-119-61711-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830428403321
• Lo trovi qui: Univ. Federico II