Protein chaperones and protection from neurodegenerative diseases / / edited by Stephan Witt

• Pubblicazione: Hoboken, : John Wiley & Sons, c2011
• Descrizione fisica: 1 online resource (448 p.)
• Disciplina: 612.8
• Soggetto topico: Molecular chaperones; Nervous system - Degeneration
• Altri autori: WittStephan N
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: PROTEIN CHAPERONES AND PROTECTION FROM NEURODEGENERATIVE DISEASES; CONTENTS; Preface; Introduction; Contributors; 1 Intrinsically Disordered Chaperones and Neurodegeneration; 2 Redox Regulation of Protein Misfolding, Synaptic Damage, and Neuronal Loss in Neurodegenerative Diseases; 3 Chaperone-Mediated Autophagy and Parkinson's Disease; 4 Chaperone and Anti-Chaperone Properties of Synuclein: Implications for Development, Aging, and Neurodegenerative Disease; 5 The Ubiquitin-Proteasome System in Neurodegenerative Diseases: More than the Usual Suspects ; 6 Regulation of the Polyglutamine Androgen Receptor by the Hsp90/Hsp70-Based Chaperone Machinery7 Amyloid Remodeling by Hsp104; 8 Chaperone-Dependent Amyloid Assembly and Prion Toxicity; 9 Modulation of Amyloid Propagation in Yeast by Hsp70 and its Regulators and Chaperone Partners; 10 ALS and the Copper Chaperone CCS; 11 Emerging Area: TorsinA, a Novel ATP-Dependent Factor Linked to Dystonia; 12 Therapeutics: Harnessing the Power of Molecular and Pharmacological Chaperones; Index
• Sommario/riassunto: How protein chaperones protect cells from neurodegenerative diseases Including contributions from leading experts, Protein Chaperones and Protection from Neurodegenerative Diseases provides an in-depth exploration of how protein chaperones are involved in shielding cells from toxic aggregated or misfolded protein states that cause ALS, Parkinson's, and related diseases. Examining how different protein chaperones ameliorate the toxicity of proteins that are known to cause neurodegenerative damage, the book addresses both research and clinical perspectives on chaperone and anti-chaperone
• Titolo autorizzato: Protein chaperones and protection from neurodegenerative diseases
• ISBN: 1-283-25775-0; 9786613257758; 1-118-06389-9; 1-118-06390-2; 1-118-06388-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910820044503321
• Lo trovi qui: Univ. Federico II
• Serie: Wiley series in protein and peptide science.