Perspectives in stem cell research [[electronic resource] /] / Brenda M. Davis and Christopher B. Halton, editors

• Pubblicazione: Hauppauge, N.Y., : Nova Science Publishers, c2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (396 p.)
• Disciplina: 616/.02774
• Soggetto topico: Stem cells
• Altri autori: DavisBrenda M HaltonChristopher B
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- PERSPECTIVES IN STEM CELL RESEARCH -- PERSPECTIVES IN STEM CELL RESEARCH -- CONTENTS -- PREFACE -- STEM CELL RESEARCH* -- SUMMARY -- OVERVIEW OF BASIC RESEARCH AND POTENTIAL APPLICATIONS -- Stem Cells from Embryos or Fetal Tissue -- Stem Cells from Adult Tissue or Umbilical Cord Blood -- Potential Applications of Stem Cell Research -- Current Federal Regulatory Landscape -- State Legislation on Embryonic Stem Cell Research -- Congressional Actions -- International Actions on Embryonic Stem Cell Research -- Ethical Issues -- REFERENCES -- CANCER STEM CELLS -- ABSTRACT -- INTRODUCTION -- STEM CELLS -- CANCER STEM CELLS -- ORIGIN OF CANCER STEM CELLS -- IDENTIFICATION AND ISOLATION OF CANCER STEM CELLS -- CANCER STEM CELL-TARGETED THERAPIES -- CONCLUSION -- REFERENCES -- PROSTATE STEM CELLS -- ABSTRACT -- THE PROSTATE GLAND -- Anatomy - The Zonal Model of the Prostate -- Peripheral Zone -- Central Zone -- Transition Zone -- Physiology of the Prostate -- PROSTATIC HYPERPLASIA AND CANCER -- Benign Prostatic Hyperplasia (BPH) -- Prostatic Intraepithelial Neoplasia -- Prostate Cancer -- ADULT STEM CELLS - A SHORT HISTORY AND PROPERTIES -- Self-renewal of Stem Cells -- Pluripotency of Adult Stem Cells -- Techniques of Isolation of Adult Stem Cell from Tissues other than Prostate -- Isolation of Adult Stem Cells from the Prostate -- TUMOR INITIATING CELLS (TICS) FROM NORMAL HUMAN PROSTATE -- FUTURE PERSPECTIVES -- REFERENCES -- MESENCHYMAL STEM CELLS IN VASCULAR THERAPY -- ABSTRACT -- I. INTRODUCTION -- II. WHAT IS A STEM CELL? -- A. Definitions and Ontogenesis -- B. Totipotent Stem Cells -- C. Pluripotent Stem Cells -- D. Multipotent Stem Cells -- E. Unipotent Stem Cells -- F. Between Differentiation and Self-Renewing: The Stem Cell Niche -- G. Stemness -- III. MESENCHYMAL STEM CELLS -- A. Origin -- 1. Historical Identification -- 2. Source. ; a) Various Species -- b) Tissue Localization -- c) Mobilization -- B. Culture -- 1. Isolation -- 2. CFU-F -- 3. A Heterogeneous Population -- 4. Phenotype -- C. Properties -- 1. Growth and Self-Renewing -- 2. The Bone Marrow Microenvironment and Hematopoiesis Support -- 3. Lineage Differentiation -- a) Mechanism -- b). Ectodermal Tissues -- c) Mesodermal Tissues -- d) Endodermal Tissues -- 4. Immunosuppressive Properties -- D. Capacities -- 1. Homing and Domiciliation -- 2. Tissue Regeneration -- 3. Oxygen Sensing -- IV. VASCULAR THERAPIES -- A. The Normal Vessel -- B. Mesenchymal Stem Cells Implication in Vascular Remodeling -- 1. MSCs and the Smooth Muscle Differentiation -- a) Bone Marrow Stroma and Vascular Smooth Muscle Phenotype -- b) The Smooth Muscle Differentiation -- c) Markers of the Smooth Muscle Differentiation -- 2. MSCs and Endothelial Trans-Differentiation -- 3. Growth Factor Release and Paracrine Effects of MSCs -- C. Stem Cell Implication during Angiogenesis, Vasculogenesis and Arteriogenesis -- 1. Stem Cell Implication during Pulmonary Remodeling -- a) Mechanisms of the Pulmonary Vascular Development -- b) Stem Cells and Pulmonary Vascular Pathologies -- 2. Stem Cell Implication during Cardiac Remodeling -- a) Cellular Therapy of Myocardial Infarction -- b) Mechanisms of Cardiac Repair -- 3. Stem Cell Implication during Systemic Vascular Remodeling -- a) Atherosclerosis -- b) Vascular Stenosis -- 4. Stem Cell Implication during Tumor Vasculature Development -- 5. MSCs and Vascular Engineering -- a) Various Materials -- b) The Mechanical Stress Impact -- c) Towards the Realization of a Functional and Complete Vessel -- CONCLUSION -- REFERENCES -- NEURAL STEM CELLS AND TAURINE -- ABSTRACT -- INTRODUCTION -- MATERIALS AND METHODS -- Differentiation of EGF-Expanded Neural Stem Cells -- Indirect Immunocytochemistry. ; Taurine Content Determination -- Data Analysis and Cell Counting -- RESULTS -- EGF- Expanded Neural Stem Cells Synthesize Taurine During Their Differentiation In Vitro -- EGF-Expanded Neural Stem Cells Express Functional Taurine Transporter During Their Differentiation In Vitro -- Role Of Taurine In The Maturation Of Oligodendrocytes Derived From EGF-Neural Stem Cells -- DISCUSSION -- ACKNOWLEDGMENTS -- REFERENCES -- CIRCULATING ENDOTHELIAL PROGENITOR CELLS: RELEVANT IN PHYSIOPATHOLOGY, A PROMISE FOR CLINICAL APPLICATIONS, AND YET SO DIFFICULT TO BE CHARACTERIZED -- ABSTRACT -- INTRODUCTION -- PHENOTYPIC CHARACTERIZATION OF EPC -- IN VITRO GROWTH OF EPCS -- MECHANISMS OF MOBILIZATION FROM BONE MARROW TO PERIPHERAL BLOOD -- HUMAN EPCS IN HEALTHY SUBJECTS -- PREGNANCY -- VASCULAR TRAUMA -- PHYSICAL ACTIVITY -- AGING -- SMOKING -- EPCS IN HUMAN PATHOLOGICAL CONDITIONS -- Cardiovascular Diseases -- Acute Myocardial Infarction (AMI) -- DIABETES MELLITUS -- HEMATOLOGICAL DISEASES -- Myelofibrosis with Myeloid Metaplasia (MMM) -- Multiple Myeloma (MM) -- CLINICAL APPLICATIONS OF ENDOTHELIAL PROGENITOR CELLS -- PHARMACOLOGICAL MOBILIZATION OF EPCS -- PHARMACOLOGICAL MOBILIZATION OF EPCS -- CONCLUSION -- ACKNOWLEDGMENT -- REFERENCES -- RED BLOOD CELL TRANSFUSIONS IN THE ERA OF REDUCED INTENSITY CONDITIONING ALLOGENEIC STEM CELL TRANSPLANTATION -- ABSTRACT -- INTRODUCTION -- I. IS FAVORABLE PATTERN OF ERYTHROPOIESIS RECOVERY THE COMMON FEATURE OF RIC CONDITIONING REGIMENS? -- RBC Transfusions After ATG-Based RIC Transplantation -- Conditioning Regimens -- PBSC Collection and Infusion -- Graft Versus Host Disease (GVHD) -- Supportive Care -- Study Design and Statistics -- Results -- RBC Transfusions -- Prognostic Factors for RBC Transfusions -- II. IS EPO ADMINISTRATION EFFECTIVE EARLY AFTER RIC ALLOTRANSPLANTATION? -- Transplantation Characteristics. ; RHuEPO Treatment -- Study Design and Statistics -- Results -- CONCLUSION -- REFERENCES -- INTERACTIONS BETWEEN TRANSPLANTED NEURAL STEM CELLS AND HOST TISSUE: A TWO-WAY STREET -- ABSTRACT -- INTRODUCTION -- SOURCES OF CELLS FOR TRANSPLANATION -- EVIDENCE OF GRAFT/HOST COMMUNICATION FOLLOWING NEURAL TRANSPLANTATION -- A. Possible Factors That Mediate Graft/Host Communication -- B. Enhancing Graft/Host Communication -- CONCLUSION -- REFERENCES -- RETROVIRUS VECTOR SILENCING IN STEM CELLS -- ABSTRACT -- 1. BACKGROUND AND PHENOMENA -- 1.1. Retrovirus Silencing -- 1.2. Retrovirus Vector Silencing -- 1.2.1. Retrovirus vector variegation -- 1.2.2. Retrovirus vector extinction after long-term culture -- 1.2.3. Retrovirus vector extinction after differentiation -- 1.2.4. Implications of retrovirus vector silencing -- 1.3. Lentivirus Vector Silencing -- 1.3.1. Lentivirus vector -- 1.3.2. Lentivirus vector silencing -- 1.4. Retrovirus Silencing is Epigenetic -- 2. EPIGENETIC GENE SILENCING BACKGROUND -- 2.1. DNA Methylation Induced Gene Silencing -- 2.1.1. DNA methyltransferases -- 3.1.2. Methylated DNA Binding Proteins And Gene Repression -- 2.2. Chromatin Structure and Gene Silencing -- 2.2.1. Histone Modification And Gene Silencing -- 2.2.2. Accessory Chromatin Proteins And Gene Silencing -- 2.3. Gene Silencing Network -- 2.4. Variegated Epigenetic Silencing -- 3. MODEL SYSTEMS USED IN RETROVIRUS SILENCING STUDIES -- 3.1. Infection Models -- 3.2. Transfection Models -- 4. RETROVIRUS VECTOR SILENCING MECHANISMS -- 4.1. Genome Defence Hypothesis -- 4.2. DNA Methylation and Retrovirus Silencing -- 4.2.1. Functional Role Of DNA Methylation In Retrovirus Silencing -- 4.2.2. DNA Methylation Independent Pathway Of Retrovirus Silencing -- 4.2.3. Relationship Between DNA Methylation Dependent And Independent Pathways. ; 4.3. Chromatin Conformation in Retrovirus Silencing -- 5. RETROVIRUS SILENCING INSULATION -- 5.1. Retrovirus Vectors That Resist Silencing -- 5.2. Insulator Elements -- 5.3. Insulation of Retrovirus and Lentivirus Silencing -- 6. RETROVIRUS SILENCING MODEL -- 7. FUTURE DIRECTIONS -- 7.1. Role of Integration Site in Determining Retrovirus Silencing -- 7.2. Retrovirus Silencing in Somatic Stem Cells -- CONCLUSION -- REFERENCES -- MIGRATION OF HEMATOPOIETIC STEM/PROGENITOR CELLS IN HEALTH AND DISEASE -- ABSTRACT -- INTRODUCTION -- MIGRATION OF HSC DURING MOBILIZATION AND HOMING TO BONE MARROW -- THE SDF-1/ CXCR4 SIGNAL TRANSDUCTION CASCADE -- MIGRATION OF HSPC IN STEADY STATE HOMEOSTASIS AND TISSUE REPAIR -- RECRUITMENT OF HSPC TO MALIGNANT TISSUE - CONTRIBUTION TO CARCINOGENESIS? -- MIGRATION CAPACITY AND ENGRAFTMENT OF EX VIVO EXPANDED HSPC -- IDENTIFICATION OF FACTORS TERMINATING HSPC MIGRATION -- CONCLUSIONS -- ACKNOWLEDGMENTS -- REFERENCES -- MORAL AND SCIENTIFIC CONSIDERATIONS IN EMBRYONIC STEM CELL RESEARCH -- ABSTRACT -- INTRODUCTION -- THE VALUE OF HES CELL RESEARCH -- The Derivation and Biology of hES Cells -- Human ES Cells and Cloning by Somatic Cell Nuclear Transfer -- Scientific and Clinical Value in the Applications for hES Cells -- Risks in Transplantation Therapies Using hES Cells -- The Use of ES Cells in Biomedical Research -- Cell and Developmental Biology -- Genetic Diseases -- Cancer -- Embryo Toxicology -- THE MORAL STATUS OF HUMAN EMBRYOS -- Defining Personhood -- Potentiality Argument -- The Cognitive Capacities Argument -- The Respect Argument -- The Symbolic Value Argument -- Instrumental Use of Human Embryos -- HARMS TO WOMEN -- Ovarian Stimulation -- Surgical Risks of Oocyte Retrieval -- Solicitation and Exploitation of Women -- ISSUES IN INFORMED CONSENT -- EMBRYO ETHICS. ; Embryos Created by Insemination: Surplus Embryos and Fresh Embryos in Research.
• Titolo autorizzato: Perspectives in stem cell research
• ISBN: 1-62081-993-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910811731103321
• Lo trovi qui: Univ. Federico II
• Serie: Stem cells--laboratory and clinical research series.