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Titolo: |
Vitamins and hormones . Volume ninety-seven Nociceptin opioid / / series editor, Gerald Litwack
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Pubblicazione: | Waltham, Massachusetts : , : Academic Press, , 2015 |
©2015 | |
Edizione: | First edition. |
Descrizione fisica: | 1 online resource (392 p.) |
Disciplina: | 612.015756 |
Soggetto topico: | Neuropeptides |
Opioid peptides | |
Nociceptive pain | |
Persona (resp. second.): | LitwackGerald |
Note generali: | Description based upon print version of record. |
Nota di bibliografia: | Includes bibliographical references at the end of each chapters and index. |
Nota di contenuto: | Front Cover; Nociceptin Opioid; Copyright; Contents; Contributors; Preface; Chapter 1: Helix-Constrained Nociceptin Peptides Are Potent Agonists and Antagonists of ORL-1 and Nociception; 1. Nociception in Brief; 1.1. Opioid receptor-like receptor-ORL-1; 1.2. Nociceptin; 1.3. Interrogating the activation and address domains of nociceptin(1-17); 2. Prospecting the Importance of the N-Terminal Tetrapeptide of Nociceptin(1-17); 3. Other Modifications to Nociceptin(1-17); 4. The Importance of Structure in Nociceptin Analogues; 4.1. Importance of helicity; 4.2. Other nociceptin derivatives |
5. Recent Advances in ORL-1 Active Nociceptin Peptides6. The Development of New Helix-Constrained Nociceptin Analogues; 6.1. Design of helix-constrained nociceptin analogues; 6.2. Helical structure of nociceptin(1-17)-NH2 analogues in water; 6.3. Nuclear magnetic resonance spectra-derived structures; 7. Biological Properties of Helical Nociceptin Mimetics; 7.1. Cellular expression of ORL-1 and ERK phosphorylation; 7.2. Agonist and antagonist activity of nociceptin(1-17)-NH2 and analogues; 7.3. Effects of helical constraint on biological activity in Neuro-2a cells | |
7.4. Stability and cell toxicity of helix-constrained versus unconstrained peptides7.5. In vivo activity of helix-constrained versus unconstrained nociceptin analogues; 8. Concluding Remarks; References; Chapter 2: Bioinformatics and Evolution of Vertebrate Nociceptin and Opioid Receptors; 1. Introduction; 1.1. The origin of G protein-coupled receptors; 1.2. A brief history of opioid receptors; 1.3. Evidence for opioid receptors in nonmammalian vertebrates; 2. The Vertebrate Opioid Receptor Sequence Database; 2.1. Alignment of protein sequences | |
2.2. Phylogenetic analysis of vertebrate opioid receptors2.3. Divergence and convergence of opioid receptor types; 3. The Human Genome and the Evolution of Opioid Receptors; 3.1. Duplicated opioid family receptor genes in the human genome; 3.2. Variation in human opioid receptor genes; 4. The Molecular Evolution of Vertebrate Opioid Family Receptors; 5. Future Directions; 6. Conclusions; Acknowledgments; References; Chapter 3: Ancestral Vertebrate Complexity of the Opioid System; 1. Introduction; 2. Opioid Peptide Family; 3. Opioid Receptor Family | |
4. Discussion: Complexity, Coevolution, and Divergence5. Conclusions; Acknowledgement; References; Chapter 4: Synthesis and Biological Activity of Small Peptides as NOP and Opioid Receptors' Ligands: View on Current Devel...; 1. Introduction; 2. Endogenous Opioid Peptides and Receptors: Nociceptin and NOP Receptor Ligands; 3. Hexapeptides with NOP Receptor Affinity; 4. Solid-Phase Peptide Synthesis; 5. Conclusions; Acknowledgment; References; Chapter 5: Pain Regulation by Nocistatin-Targeting Molecules: G Protein-Coupled-Receptor and Nocistatin-Interacting Protein; 1. Introduction | |
2. Biological Activity by NST Through G Protein-Coupled Receptor | |
Sommario/riassunto: | First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nociceptin opioid. Key features: Expertise of the contributorsCoverage of a vast array of subjectsIn |
Titolo autorizzato: | Vitamins and hormones ![]() |
ISBN: | 0-12-802593-X |
0-12-802443-7 | |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910787429703321 |
Lo trovi qui: | Univ. Federico II |
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