Fundamentals of heterocyclic chemistry [[electronic resource] ] : importance in nature and in the synthesis of pharmaceuticals / / Louis D. Quin, John A. Tyrell

• Autore: Quin Louis D. <1928->
• Pubblicazione: Hoboken, N.J., : Wiley, c2010
• Descrizione fisica: 1 online resource (345 p.)
• Disciplina: 547/.59
• Soggetto topico: Heterocyclic chemistry; Heterocyclic compounds - Synthesis
• Soggetto genere / forma: Electronic books.
• Altri autori: TyrellJohn A
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: FUNDAMENTALS OF HETEROCYCLIC CHEMISTRY; CONTENTS; PREFACE; ACKNOWLEDGMENT; Chapter 1 THE SCOPE OF THE FIELD OF HETEROCYCLIC CHEMISTRY; References; Appendix; Chapter 2 COMMON RING SYSTEMS AND THE NAMING OF HETEROCYCLIC COMPOUNDS; 2.1. General; 2.2. Naming Simple Monocyclic Compounds; 2.3. Handling the "Extra Hydrogen"; 2.4. Substituted Monocyclic Compounds; 2.5. Rings With More Than One Heteroatom; 2.6. Bicyclic Compounds; 2.7. Multicyclic Systems; 2.8. The Replacement Nomenclature System; 2.9. Saturated Bridged Ring Systems; References; Review Exercises ; Chapter 3 NATURE AS A SOURCE OF HETEROCYCLIC COMPOUNDS3.1. General; 3.2. Naturally Occurring Nitrogen Heterocyclic Compounds; 3.3. Oxygen Compounds; 3.4. Sulfur and Phosphorus Heterocyclic Compounds in Nature; References; Chapter 4 PRINCIPLES OF SYNTHESIS OF AROMATIC HETEROCYCLES BY INTRAMOLECULAR CYCLIZATION; 4.1. General; 4.2. Some of the Classic Synthetic Methods; 4.3. Cyclizations Involving Metallic Complexes as Catalysts; 4.4. Cyclizations with Radical Intermediates; 4.5. Cyclizations by Intramolecular Wittig Reactions; 4.6. Synthesis of Heterocycles by the Alkene Metathesis Reaction ; ReferencesReview Exercises; Chapter 5 SYNTHESIS OF HETEROCYCLIC SYSTEMS BY CYCLOADDITION REACTIONS; 5.1. The Diels-Alder Reaction; 5.2. Dipolar Cycloadditions; 5.3. [2 + 2] Cycloadditions; References; Review Exercises; Chapter 6 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-DEFICIENT RING SYSTEMS; 6.1. General; 6.2. Review of the Aromaticity of Benzene; 6.3. Pi-Deficient Aromatic Heterocycles; References; Review Exercises; Chapter 7 AROMATICITY AND OTHER SPECIAL PROPERTIES OF HETEROCYCLES: PI-EXCESSIVE RING SYSTEMS AND MESOIONIC RING SYSTEMS ; 7.1. Pi-Excessive Aromatic Heterocycles7.2. Mesoionic Heterocycles; References; Review Exercises; Chapter 8 THE IMPORTANCE OF HETEROCYCLES IN MEDICINE; 8.1. General; 8.2. Historical; 8.3. Pyridines; 8.4. Indoles; 8.5. Quinolines; 8.6. Azepines; 8.7. Pyrimidines; 8.8. Concluding Remarks; References; Chapter 9 SYNTHETIC METHODS FOR SOME PROMINENT HETEROCYCLIC FAMILIES: EXAMPLES OF PHARMACEUTICALS SYNTHESIS; 9.1. Scope of the Chapter; 9.2. Pyrroles; 9.3. Furans; 9.4. Thiophenes; 9.5. 1,3-Thiazoles; 9.6. 1,3-Oxazoles; 9.7. Imidazoles; 9.8. Pyrazoles; 9.9. 1,2,4-Triazoles; 9.10. Tetrazoles ; 9.11. 1,3,4-Thiadiazoles and other 5-Membered Systems9.12. Indole; 9.13. Pyridines; 9.14. Quinolines and Isoquinolines; 9.15. Benzodiazepines; 9.16. Pyrimidines; 9.17. Fused Pyrimidines: Purines and Pteridines; 9.18. 1,3,5-Triazines; 9.19. Multicyclic Compounds; References; Review Exercises; Chapter 10 GEOMETRIC AND STEREOCHEMICAL ASPECTS OF NONAROMATIC HETEROCYCLES; 10.1. General; 10.2. Special Properties of Three-Membered Rings; 10.3. Closing Heterocyclic Rings: Baldwin's Rules; 10.4. Conformations of Heterocyclic Rings; 10.5. Chirality Effects on Biological Properties of Heterocycles ; References
• Sommario/riassunto: Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularlyIntroduces students to heterocyclic chemistry and synthesis with practical examples of applied methodologyEmphasizes natural product and pharmaceutical applicationsProvides graduate students and researchers in the pharmaceutical and related sciences with a background in the fieldIncludes problem sets with several chapters
• Titolo autorizzato: Fundamentals of heterocyclic chemistry
• ISBN: 1-282-70770-1; 9786612707704; 0-470-62653-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910458809103321
• Lo trovi qui: Univ. Federico II