Polymorphism in the pharmaceutical industry [[electronic resource] /] / edited by Rolf Hilfiker

• Pubblicazione: Weinheim, : Wiley-VCH, c2006
• Descrizione fisica: 1 online resource (436 p.)
• Disciplina: 660.28
• Soggetto topico: Crystallography; Solid state chemistry; Chemical engineering; Pharmaceutical chemistry
• Altri autori: HilfikerRolf
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Polymorphism; Contents; Preface; List of Contributors; 1 Relevance of Solid-state Properties for Pharmaceutical Products; 1.1 Introduction; 1.2 Drug Discovery and Development; 1.3 Bioavailability of Solids; 1.4 Phases of Development and Solid-state Research; 1.4.1 Salt Selection; 1.4.2 Polymorph Screening; 1.4.3 Crystallization Process Development; 1.4.4 Formulation; 1.4.5 Method Development; 1.5 Solid-state and Life Cycle Management; 1.6 Conclusions; References; 2 Thermodynamics of Polymorphs; 2.1 Introduction; 2.2 Structural Origin of Polymorphism; 2.3 Thermodynamic Theory of Polymorphism ; 2.4 Thermodynamic Relationship Between Polymorphs: Enantiotropy and Monotropy2.4.1 Energy-Temperature Diagrams; 2.4.2 Pressure-Temperature Diagrams; 2.4.3 Inversion of Polymorphic Behavior; 2.5 Rules to Predict Thermodynamic Relationships Between Polymorphs; 2.5.1 Heat of Transition Rule; 2.5.2 Heat of Fusion Rule; 2.5.3 Entropy of Fusion Rule; 2.5.4 Heat Capacity Rule; 2.5.5 Density Rule; 2.5.6 Infrared Rule; 2.6 Relative Thermodynamic Stabilities of Polymorphs; 2.7 Crystallization of Polymorphs; 2.7.1 Nucleation of Polymorphs; 2.8 Introduction to Solvates and Hydrates ; 2.8.1 Thermodynamics of Hydrates2.9 Summary; References; 3 Characterization of Polymorphic Systems Using Thermal Analysis; 3.1 Introduction - Scope of the Chapter; 3.2 Use of Differential Scanning Calorimetry for the Characterization of Polymorphs; 3.2.1 Principles of DSC in the Context of Polymorphism; 3.2.2 Examples of the Uses of DSC: Characterization of Drugs, Excipients and Dosage Forms; 3.2.3 Further Uses of DSC; 3.3 Combined Approaches; 3.3.1 Multi-instrument Approaches; 3.3.2 Thermal and Crystallographic Studies; 3.3.3 Interfaced Techniques ; 3.4 Additional Thermal Methods for the Study of Polymorphism3.4.1 Thermogravimetric Analysis; 3.4.2 Thermal Microscopy; 3.4.3 Heat of Solution Studies; 3.4.4 Modulated Temperature DSC; 3.4.5 High-speed DSC; 3.4.6 Microthermal Analysis; 3.4.7 Thermally Stimulated Current; 3.5 Conclusions; References; 4 Solid-state NMR Spectroscopy; 4.1 Introduction; 4.1.1 Basics of Solid-state NMR; 4.2 Applications; 4.2.1 Identification; 4.2.2 Selectivity; 4.2.3 Mobility and Dynamics; 4.2.4 Quantitation of Forms; 4.3 Conclusions; References ; 5 Vibrational Spectroscopic Methods in Pharmaceutical Solid-state Characterization5.1 Introduction; 5.2 Mid-infrared, Raman and THz Spectroscopy: Basic Comparison of Theory, Instrumentation and Sampling; 5.2.1 Basic Theory; 5.2.2 Instrumentation Brief; 5.2.3 Sampling; 5.2.3.1 Raman Sampling [20, 23, 30]; 5.2.3.2 Mid-infrared Sampling [30, 39-41]; 5.2.3.3 THz Spectroscopy Sample Presentation; 5.3 Changes of State and Solid-state Effects on Infrared and Raman Spectra; 5.3.1 Introduction; 5.3.2 Spectra of Gases, Liquids and Solutions; 5.3.3 Hydrogen Bonding ; 5.3.4 Amine Salts (including Amino Acids)
• Sommario/riassunto: Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries.With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent depart
• Titolo autorizzato: Polymorphism in the pharmaceutical industry
• ISBN: 1-280-72340-8; 9786610723409; 3-527-60788-9; 3-527-60772-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910841149603321
• Lo trovi qui: Univ. Federico II