Oligonucleotide-based drugs and therapeutics : preclinical and clinical considerations for development / / edited by Nicolay Ferrari, Rosanne Seguin

• Pubblicazione: John Wiley & Sons, Inc
• Disciplina: 572.8/5
• Soggetto topico: Oligonucleotides - Therapeutic use; Antisense nucleic acids - Therapeutic use
• Persona (resp. second.): FerrariNicolay <1969->; SeguinRosanne
• Nota di contenuto: Mechanisms of oligonucleotide actions -- The medicinal chemistry of antisense oligonucleotides -- Cellular pharmacology of antisense oligonucleotides -- Pharmacokinetics and pharmacodynamics of antisense oligonucleotides -- Tissue distribution, metabolism and clearance -- Hybridization-independent effects : principles and specific considerations for oligonucleotide drugs -- Hybridization-dependent effects : the prediction, evaluation and consequences of unintended target hybridization -- Class-related proinflammatory effects -- Exaggerated pharmacology -- Genotoxicity tests for novel oligonucleotide-based therapeutics -- Reproductive and developmental toxicity testing strategies for oligonucleotide-based therapeutics -- Specific considerations for preclinical development of inhaled oligonucleotides -- Lessons learned in oncology programs -- Inhaled antisense for treatment of respiratory disease -- Antisense oligonucleotides for treatment of neurology diseases -- Nucleic acids as adjuvants -- Splice-switching oligonucleotides -- CMC aspects for the clinical development of spiegelmers.
• Titolo autorizzato: Oligonucleotide-based drugs and therapeutics
• ISBN: 1-119-07030-9; 1-119-07029-5; 1-119-07015-5
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830042603321
• Lo trovi qui: Univ. Federico II