Signal transduction in cancer / / edited by David A. Frank

• Pubblicazione: Boston, : Kluwer Academic Publishers, c2003
• Edizione: 1st ed. 2003.
• Descrizione fisica: 1 online resource (VIII, 357 p.)
• Disciplina: 616.99/4071
• Soggetto topico: Carcinogenesis; Cancer - Molecular aspects; Cellular signal transduction
• Altri autori: FrankDavid A. <1960->
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Receptors -- Growth, Survival and Migration: The Trk to Cancer -- The Role of Growth Factor Signaling in Malignancy -- TGF-? Signaling Alterations in Cancer -- Notch in Malignancy -- Intracellular Pathways -- cAMP Signaling in Cancer Genesis and Treatment -- PI3K/PTEN/Akt Pathway -- Wnt Signaling in Human Cancer -- Ras Signaling, Deregulation of Gene Expression and Oncogenesis -- Role of the RB Tumor Suppressor in Cancer -- Transcription Factors -- The Rel/NF-?B/I?B Signal Transduction Pathway and Cancer -- STAT Signaling in Cancer: Insights into Pathogenesis and Treatment Strategies -- Steroid Hormone Receptor Signaling in Cancer -- Cell Death Pathways -- Cell Death Signaling in Malignancy -- Ceramide and Sphingosine 1-Phosphate in Anti-Cancer Therapies.
• Sommario/riassunto: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets.".
• Titolo autorizzato: Signal transduction in cancer
• ISBN: 0-306-48158-8; 9786610461790; 1-280-46179-9
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910825368503321
• Lo trovi qui: Univ. Federico II
• Serie: Cancer treatment and research ; ; v. 115.