Adverse reproductive outcomes in families of atomic veterans : the feasibility of epidemiologic studies / / Committee to Study the Feasibility of, and Need for, Epidemiologic Studies of Adverse Reproductive Outcomes in the Families of Atomic Veterans, Medical Follow-up Agency, Institute of Medicine

• Pubblicazione: Washington, D.C., : National Academy Press, 1995
• Edizione: 1st ed.
• Descrizione fisica: x, 97 p
• Disciplina: 616/.043
• Soggetto topico: Radiation - Physiological effect; Veterans - Diseases; Radiation victims; Teratogenesis; Abnormalities, Human
• Note generali: "Support for this project was provided by the Department of Veterans Affairs (contract no. V101-(93)P-1469)"--T.p. verso.
• Nota di bibliografia: Includes bibliographical references (p. 91-97).
• Nota di contenuto: Adverse Reproductive Outcomes in Families of Atomic Veterans: The Feasibility of Epidemiologic Studies -- Copyright -- Preface -- Contents -- Executive Summary -- CONCLUSIONS -- ORGANIZATION AND FRAMEWORK OF THE REPORT -- ADVERSE REPRODUCTIVE OUTCOMES -- ESTIMATION OF GENETIC RISK -- FEASIBILITY OF AN EPIDEMIOLOGIC STUDY -- Question 1. Definition of the Study Sample -- Question 2. Sample Size -- Question 3. Dose -- Question 4. Identification of Adverse Reproductive Outcomes -- ALTERNATIVE APPROACHES -- 1 Introduction -- AIMS OF THIS REPORT -- 2 Basic Epidemiologic Issues -- 3 Feasibility and Design of an Epidemiologic Study -- STUDY COHORT -- MEASUREMENT OF EXPOSURE -- DEFINING THE DISEASE AND ASCERTAINING THE CASES -- 4 Basic Principles of Radiation Biology -- BIOLOGICAL EFFECTS -- SOURCES OF RADIATION EXPOSURE -- POTENTIALLY SENSITIVE SUBGROUPS -- 5 Genetic Principles and Issues -- 6 Current Knowledge and Estimation of Genetic Risk -- BASIC ESTIMATION EQUATION -- DATA FROM WHICH RISK ESTIMATES HAVE BEEN MADE -- Mice -- Humans -- Estimating the Spontaneous Burden -- Estimating the Effect of Ionizing Radiation -- ESTIMATING THE DOUBLING DOSE -- Mice -- Humans -- 7 Adverse Reproductive Outcomes -- GENERAL REMARKS -- MALE-MEDIATED REPRODUCTIVE AND DEVELOPMENTAL OUTCOMES -- INFERTILITY -- Radionuclide Irradiation -- SPONTANEOUS ABORTIONS -- PRETERM DELIVERY -- STILLBIRTHS AND NEONATAL DEATHS (PERINATAL DEATHS) -- BIRTH DEFECTS -- Human Chromosome Abnormalities -- Developmental Abnormalities -- MATERNAL ILLNESSES -- ALTERED SEX RATIO -- MORTALITY AMONG THE CHILDREN OF EXPOSED PARENTS -- CANCER AND LEUKEMIA IN PARTICULAR -- IMMUNE DEFICIENCY -- NEUROLOGIC DEFICIT, INCLUDING MENTAL RETARDATION -- 8 Feasibility of the Study of Adverse Reproductive Outcomes in the Families of Veterans Exposed Ionizing Radiation. ; DEFINITION OF A SUITABLE SAMPLE OR COHORT -- SIZE OF THE SAMPLE OR COHORT REQUIRED -- Question 1 -- Question 2 -- DOSIMETRY OF ATOMIC VETERANS -- IDENTIFICATION OF ADVERSE REPRODUCTIVE OUTCOMES -- 9 Alternative Approaches -- 10 Conclusions -- Glossary -- References.
• Titolo autorizzato: Adverse reproductive outcomes in families of atomic veterans
• ISBN: 0-309-17611-5; 1-280-19267-4; 9786610192670; 0-309-58848-0; 0-585-14335-8
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910812204403321
• Lo trovi qui: Univ. Federico II