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Nanobiosensors for point-of-care medical diagnostics / / Manashjit Gogoi, Sanjukta Patra, Debasree Kundu, editors



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Titolo: Nanobiosensors for point-of-care medical diagnostics / / Manashjit Gogoi, Sanjukta Patra, Debasree Kundu, editors Visualizza cluster
Pubblicazione: Singapore : , : Springer, , [2022]
©2022
Descrizione fisica: 1 online resource (287 pages)
Disciplina: 610.28
Soggetto topico: Biosensors
Nanostructured materials
Point-of-care testing
Point-of-Care Testing
Nanostructures
Diagnostic Techniques and Procedures
Persona (resp. second.): KunduDebasree
PatraSanjukta
GogoiManashjit
Nota di contenuto: Intro -- Preface -- Acknowledgement -- Contents -- Editors and Contributors -- Chapter 1: Point-of-Care Biosensors for Healthcare Applications -- 1.1 Introduction -- 1.2 Biosensors for POC Testing -- 1.3 Application of POC Biosensors in Healthcare -- 1.3.1 POC Biosensors for Detection of Cardiovascular Diseases -- 1.3.1.1 Handheld POC Biosensor Devices -- 1.3.1.2 RDT POC Biosensor Devices -- 1.3.1.3 Benchtop POC Biosensor Devices -- 1.3.2 POC Biosensor for Cholesterol Detection -- 1.3.3 POC Biosensors for Detection of Diabetes -- 1.3.4 POC Biosensors for Detection of Kidney Diseases -- 1.3.5 POC Biosensors for Detection of Cancer -- 1.3.6 POC Biosensors for Detection of COVID-19 -- 1.3.7 POC Biosensor for Detection of Other Diseases -- 1.4 Challenges and Future Prospects -- 1.5 Conclusions -- References -- Chapter 2: An Overview of Biomolecules Used in the Development of Point-of-Care Sensor -- 2.1 Introduction -- 2.2 Proteins -- 2.2.1 Peptides -- 2.2.2 Enzymes -- 2.2.3 Antibodies -- 2.2.3.1 Polyclonal Antibodies -- 2.2.3.2 Monoclonal Antibodies -- 2.2.3.3 Recombinant Antibodies -- 2.2.4 Nanobodies -- 2.2.5 Lateral Flow Assay (LFA) Immunosensors -- 2.2.6 Lectins -- 2.2.7 Receptors Proteins -- 2.3 Nucleic Acid -- 2.3.1 Nucleic Acid Amplification Tests (NAATs) -- 2.3.1.1 Loop-Mediated Isothermal Amplification (LAMP) -- 2.3.1.2 Nucleic Acid Sequence-Based Amplification (NASBA) -- 2.3.1.3 Rolling Circle Amplification (RCA) -- 2.3.1.4 Molecular Beacon-Assisted Detection-Amplification (BAD AMP) -- 2.3.1.5 Hybridization Chain Reaction (HCR) -- 2.3.2 Molecular Beacons (MB) -- 2.3.3 Aptamers -- 2.3.3.1 Simple Analyte-Binding Assay -- 2.3.3.2 Aptamer Folding Assay -- 2.3.3.3 Aptamer-Switching Sensors -- 2.3.3.4 Split-Aptamer Sensors -- 2.3.4 Catalytic Nucleic Acids -- 2.3.5 Peptide Nucleic Acids (PNA) -- 2.4 Whole-Cell Biosensors.
2.4.1 Bacteriophage-Based Biosensors -- 2.5 Future Aspects -- References -- Chapter 3: Nanomaterials for Point-of-Care Biosensors -- 3.1 Introduction -- 3.2 Components of Biosensors -- 3.2.1 Analytes -- 3.2.2 Biological Recognition Elements/Bioreceptors -- 3.2.3 Transducers -- 3.2.4 Signal Processing Unit -- 3.3 Nanomaterials Used in POC Biosensors -- 3.3.1 Biological Recognition Elements/Receptors -- 3.3.1.1 Enzymes -- 3.3.1.2 Nucleic Acids -- 3.3.1.3 Antibodies -- 3.3.2 Nanomaterials or Nanostructured Materials -- 3.3.2.1 Organic Nanoparticles -- Carbon-Based Nanoparticles -- Dendrimers -- 3.3.2.2 Inorganic Nanoparticles -- Metal Nanoparticles -- Magnetic Nanoparticles -- Semiconductor Nanoparticles -- Polymeric Nanoparticles -- Hydrogels -- Molecular Machines -- Thin Films -- 3.4 Challenges and Future Prospects -- 3.5 Conclusions -- References -- Chapter 4: New-Generation Molecular Techniques in POC Biosensors for Detection of Infectious Diseases -- 4.1 Introduction -- 4.1.1 Infectious Diseases: An Overview of the Challenges and Recent Outbreaks -- 4.1.2 Point-of-Care Biosensors for Pathogen Detection -- 4.2 Sample Concentration: Requirements and Challenges -- 4.2.1 Aptamers as Next-Generation Affinity Probes -- 4.2.2 The Role of Aptamers in POC Biosensors -- 4.3 Advanced Molecular Detection Strategies -- 4.3.1 Solid-Phase PCR: Principle and Approach -- 4.3.2 Isothermal Amplification: An Overview -- 4.3.2.1 Loop-Mediated Isothermal Amplification (LAMP): Principle and Approach -- 4.3.2.2 Strand Displacement DNA Polymerase -- 4.3.2.3 Significance and Challenges in Designing Fold-Back Primers -- 4.3.2.4 Detection Principles Adapted in the LAMP Reactions -- 4.3.2.5 Feasibility of LAMP for Multiplexed POC Diagnostics -- 4.3.2.6 Merits and Limitations of LAMP in POC Diagnostics.
4.4 Challenges in the Development of POC Biosensors and Suggested Solutions -- 4.5 Conclusion and Outlook -- References -- Chapter 5: Point-of-Care Biosensors for Glucose Sensing -- 5.1 Introduction -- 5.1.1 Importance of Glucose Levels in the Human Body -- 5.1.2 Fundamentals of Biochemical Analysis of Glucose -- 5.2 Glucose Biosensors -- 5.2.1 Types of Glucose Biosensors (Enzyme-Based, Colorimetric-Based) -- 5.2.1.1 Enzyme-Based Glucose Biosensors -- 5.2.1.2 Non-enzymatic (Calorimetric)-Based Glucose Biosensor -- 5.3 POC Devices for Glucose Biosensing -- 5.4 Commercially Available POC Devices for Glucose Biosensing -- 5.5 Sources of Errors in Glucose Monitoring -- 5.6 Safety and Handling of POC Devices -- 5.7 Robustness and Ease of Use -- 5.8 Safety and SOP -- 5.9 Waste and Disposal -- 5.10 Challenges and Troubleshooting for POC Devices -- 5.11 Conclusion -- References -- Chapter 6: Overview of Affordable Upfront Point-of-Care Testing for Cancer Detection -- 6.1 Introduction -- 6.2 Cancer and Their Biomarkers -- 6.3 Biosensors for Detection of Cancer -- 6.3.1 Breast Cancer Biosensors -- 6.3.2 Biosensors for Colon and Rectal Cancer Diagnostics -- 6.3.3 POC Biosensors for Bladder Cancer -- 6.3.4 POC Biosensors for Kidney Cancer -- 6.3.5 POC Biosensors for Leukaemia -- 6.3.6 Melanoma Biosensors -- 6.3.7 Biosensors for Lymphoma Cancer -- 6.3.8 POC Biosensors for Lung Cancer -- 6.3.9 POC Device for Pancreatic Cancer -- 6.3.10 POC Biosensors for Prostate Cancer -- 6.3.11 POC Biosensors for Thyroid Cancer -- 6.4 Future of POC-Based Biosensors -- 6.5 Conclusion -- References -- Chapter 7: Point-of-Care Diagnostic Testing in Urgent Cardiac Care -- 7.1 Introduction -- 7.2 Point-of-Care CVD Testing -- 7.3 Biomarkers in Cardiovascular Diseases -- 7.3.1 Stand Alone and Unique Biomarkers -- 7.3.1.1 Cardiac Troponin.
7.3.1.2 Brain Natriuretic Peptide (BNP) and N-Terminal proBNP (NT-pro-BNP) -- 7.3.1.3 C-Reactive Protein (CRP) -- 7.3.1.4 Mid-Regional Pro-Atrial Natriuretic Peptide (MR-proANP) -- 7.3.1.5 Copeptin -- 7.3.1.6 Galectin-3 -- 7.3.2 Biomarkers that Provide Additive Information in Cardiovascular Patients -- 7.3.2.1 Myoglobin -- 7.3.2.2 Creatine Kinase-Muscle Brain (CK-MB) -- 7.3.2.3 Myeloperoxidase -- 7.3.2.4 Low-Density and High-Density Lipoprotein -- 7.3.2.5 Interleukin-6 (IL-6) -- 7.4 Biosensors for Cardiovascular Diseases -- 7.4.1 Clinical Biosensors for CVD Detection -- 7.4.1.1 Available Point-of-Care Devices for CVD Biomarkers -- 7.4.1.2 Multiplexed Biosensor for Cardiovascular Diseases -- 7.4.2 Research Platforms for CVD Biomarkers -- 7.4.3 Recent Research Advancements for Multiplexed Biosensors -- 7.5 Detection Platforms for CVD in Research -- 7.5.1 Optical Biosensors -- 7.5.2 Electrochemical Based Biosensors -- 7.5.3 Magnetic Biosensors -- 7.6 Challenges for Development of Biosensing Platforms in CVD Detection -- 7.7 Conclusion -- References -- Chapter 8: Point-of-Care Nanobiosensors for Determining Vitamin Deficiency -- 8.1 Introduction -- 8.2 Nanobiosensors for Determining Vitamin Deficiencies -- 8.2.1 Nanobiosensors for the B-Complex Group of Vitamins -- 8.2.2 Nanobiosensors for Vitamin C Detection -- 8.2.3 Nanobiosensors for Vitamin D Detection -- 8.2.4 Nanosensors for Vitamin E Detection -- 8.2.5 Nanobiosensor for Vitamin A Detection -- 8.3 Challenges and Future Prospects -- 8.4 Conclusions -- Glossary -- References -- Chapter 9: Utility of Nanobiosensors as a Point-of-Care Diagnostics for Neurological Disorders: From Bench to Bedside -- 9.1 Introduction -- 9.2 Point-of-Care Diagnosis and Nanobiosensors -- 9.2.1 Biosensors -- 9.2.2 Nanobiosensor -- 9.3 Novel Approaches for Development of Nanobiosensor-Based Diagnostics.
9.3.1 Lateral Flow Biosensors -- 9.3.2 Optic Based Sensors -- 9.3.3 Microfluidics-Based Nanobiosensors -- 9.3.4 Microarray-Based Nanobiosensor -- 9.4 Nanobiosensors and Diagnostic Landscape of Neurodegenerative Diseases -- 9.4.1 Nanobiosensor Technology in Diagnostic of Acute Stroke -- 9.4.2 Nanobiosensor Technology in Diagnostic of Alzheimer´s Disease -- 9.4.3 Nanobiosensor Technology in Diagnostic of Parkinson´s Disease (PD) -- 9.5 Translational Challenges of POC Nanobiosensors for Diagnosis of Neurological Disease -- 9.6 Conclusions -- References -- Chapter 10: Point-of-Care Testing and Diagnostics for Sexually Transmitted Disease -- 10.1 Introduction -- 10.2 Sexually Transmitted Disease and Infection (STD/STIs) -- 10.2.1 STD/STI Epidemiology -- 10.2.2 Disease Organisms and Laboratory Based Evaluation -- 10.2.2.1 Gonorrhea -- 10.2.2.2 Chlamydia -- 10.2.2.3 Trichomoniasis -- 10.2.2.4 Syphilis -- 10.2.2.5 Chancroid -- 10.2.2.6 Herpes Simplex Virus -- 10.2.2.7 Lymphogranuloma Venereum (LGV) -- 10.3 POCT and STD/STI -- 10.3.1 Basic of POCT -- 10.3.2 Nano Sensors in POCT -- 10.3.2.1 Biosensors POCTs -- 10.3.2.2 Microfluidics Bases POCTs -- 10.3.3 POCT in Monitoring STD/STI -- 10.3.3.1 Gonorrhea -- 10.3.3.2 Chlamydia -- 10.3.3.3 Trichomoniasis -- 10.3.3.4 Syphilis -- 10.3.3.5 Chancroid -- 10.3.3.6 Herpes Simplex Virus -- 10.4 Present Challenges and Future of POCT in STD/STI Spread and Diagnosis -- 10.5 Conclusions -- References -- Chapter 11: Nanobiosensor-Based Microfluidic Point-of-Care Platforms: Fabrication, Characterization, and Applications -- 11.1 Introduction -- 11.1.1 Point-of-Care: Definition, Concept, and Evolution -- 11.2 Noble Metal Nanoparticles as a Sensing Element in Point-of-Care -- 11.2.1 AgNPs and AuNPs as Nanoprobes for Detection of Cancerous Cells -- 11.3 Lab-on-Chip Based Biosensing -- 11.3.1 Microfluidic ELISA Chip.
11.3.2 Fabrication of Microfluidic POCs.
Titolo autorizzato: Nanobiosensors for point-of-care medical diagnostics  Visualizza cluster
ISBN: 981-19-5141-1
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910637713903321
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