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Titolo: | Mucus hypersecretion in respiratory disease [[electronic resource]] |
Pubblicazione: | Chichester, West Sussex, England ; ; Hoboken, NJ, USA, : Wiley, 2002 |
Descrizione fisica: | 1 online resource (304 p.) |
Disciplina: | 616.2 |
Soggetto topico: | Mucous membrane |
Respiratory organs - Diseases | |
Soggetto genere / forma: | Electronic books. |
Altri autori: | ChadwickDerek GoodeJamie |
Note generali: | "Editors, Derek J. Chadwick and Jamie A. Goode"--P. [v]. |
"Symposium on Mucus Hypersecretion in Respiratory Disease, held at the Novartis Foundation, London, 26-28 February 2002"--P. [v]. | |
Nota di bibliografia: | Includes bibliographical references and indexes. |
Nota di contenuto: | MUCUS HYPERSECRETION IN RESPIRATORY DISEASE; Contents; Participants; Chair's introduction; Epidemiological studies in mucus hypersecretion; Discussion; Post-secretory fate of host defence components in mucus; Discussion; Mechanisms of submucosal gland morphogenesis in the airway; Discussion; Mucin-producing elements and inflammatory cells; Discussion; Respiratory tract mucins: structure and expression patterns; Discussion; Development and validation of a lectin-based assay for the quantitation of rat respiratory mucin; Discussion; Regulation of mucin secretion from in vitro cellular models |
DiscussionOscillations of pH inside the secretory granule control the gain of Ca(2+) release for signal transduction in goblet cells exocytosis; Discussion; A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction; Discussion; Mechanisms by which Gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR); Discussion; Non-allergic models of mucous cell metaplasia and mucus hypersecretion in rat nasal and pulmonary airways; Discussion | |
Cytokine regulation of mucus production in a model of allergic asthmaDiscussion; The role of apoptotic regulators in metaplastic mucous cells; Discussion; Current and future therapies for airway mucus hypersecretion; Discussion; Clinical evaluation of new therapies for treatment of mucus hypersecretion in respiratory diseases; Discussion; Final general discussion; Index of contributors; Subject index | |
Sommario/riassunto: | A number of chronic respiratory diseases including chronic bronchitis, asthma, cystic fibrosis and bronchiectasis are characterized by mucus hypersecretion. Following damage to the airway epithelium, a repair process of dedifferentiation, regenerative proliferation and redifferentiation takes place that is invariably accompanied by mucus hypersecretion as a key element in the host defence mechanism. In chronic respiratory diseases, however, excessive mucus production leads to a pathological state with increased risk of infection, hospitalization and morbidity. An understanding of the mechanism |
Titolo autorizzato: | Mucus hypersecretion in respiratory disease |
ISBN: | 1-280-27111-6 |
9786610271115 | |
0-470-66827-X | |
0-470-85929-6 | |
0-470-86079-0 | |
Formato: | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910143168603321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |