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Solid-phase organic synthesis [[electronic resource] ] : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam



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Titolo: Solid-phase organic synthesis [[electronic resource] ] : concepts, strategies, and applications / / edited by Patrick H. Toy, Yulin Lam Visualizza cluster
Pubblicazione: Hoboken, NJ, : Wiley, 2012
Edizione: 1st ed.
Descrizione fisica: 1 online resource (562 p.)
Disciplina: 547/.2
Soggetto topico: Solid-phase synthesis
Organic compounds - Synthesis
Classificazione: SCI013050
Altri autori: ToyPatrick H  
LamYulin  
Note generali: Description based upon print version of record.
Nota di bibliografia: Includes bibliographical references and index.
Nota di contenuto: SOLID-PHASE ORGANIC SYNTHESIS: Concepts, Strategies, and Applications; CONTENTS; Preface; Acknowledgments; Contributors; Part I: CONCEPTS AND STRATEGIES; 1 LINKER STRATEGIES IN MODERN SOLID-PHASE ORGANIC SYNTHESIS; 1.1 Introduction; 1.2 Classical Linker Strategies; 1.2.1 Acid and Base Cleavable Linker Units; 1.2.2 Cyclorelease Linker Units; 1.2.3 Traceless Linker Units; 1.2.4 Photolabile Linker Units; 1.2.5 Safety-Catch Linker Units; 1.3 Multifunctional Linker Strategies; 1.3.1 Nitrogen Linker Units; 1.3.1.1 Triazene Linker Units; 1.3.1.2 Hydrazone Linker Units
1.3.1.3 Benzotriazole Linker Units1.3.2 Sulfur Linker Units; 1.3.3 Phosphorus Linker Units; 1.3.4 Selenium and Tellurium Linker Units; 1.3.5 Silyl and Germyl Linker Units; 1.3.6 Boron and Stannane Linker Units; 1.3.7 Bismuth Linker Units; 1.3.8 Alkene Linker Units; 1.4 Conclusions; References; 2 COLORIMETRIC TEST FOR SOLID-PHASE ORGANIC SYNTHESIS; 2.1 Introduction; 2.2 Functional Group Tests; 2.2.1 Amine Groups; 2.2.1.1 Ninhydrin (Kaiser) Test; 2.2.1.2 TNBSA Test; 2.2.1.3 Bromophenol Blue Test; 2.2.1.4 Chloranil Test; 2.2.1.5 DABITC Test; 2.2.1.6 MGI Test; 2.2.1.7 Isatin Test
2.2.1.8 DESC Test2.2.1.9 NPIT Test; 2.2.1.10 NF31 Test; 2.2.1.11 Nondestructive NF31 Test; 2.2.1.12 Naphthol Test; 2.2.1.13 2-Amino-3-chloro-1,4-naphthoquinone Test; 2.2.2 Alcohols; 2.2.2.1 PNBP Test; 2.2.2.2 TCT-AliR and TCT-Fluorescein Test; 2.2.2.3 Diphenyldichlorosilane-Methyl Red Test; 2.2.2.4 9-Anthronylnitrile Test; 2.2.2.5 NMA Test; 2.2.2.6 Protecting Group NPB Test; 2.2.2.7 Methyl Red/DIC Test; 2.2.2.8 Other Methods; 2.2.3 Thiol Groups; 2.2.3.1 Ellman's Test; 2.2.3.2 Other Methods; 2.2.4 Halogen Groups; 2.2.4.1 Fluorescein Test; 2.2.4.2 Other Methods; 2.2.5 Carboxylic Acid Groups
2.2.5.1 Malachite Green Test2.2.5.2 PDAM Test; 2.2.6 Aldehyde and Ketone Groups; 2.2.6.1 Fluorescent Dansylhydrazine Test; 2.2.6.2 p-Anisaldehyde Test; 2.2.6.3 Purpald Test; 2.3 Conclusions; References; 3 PRACTICAL ASPECTS OF COMBINATORIAL SOLID-PHASE SYNTHESIS; 3.1 Introduction; 3.1.1 What Is Combinatorial Chemistry; 3.1.2 What Is Not Combinatorial Chemistry; 3.1.3 History of Combinatorial Chemistry: Breakthrough Discoveries That Shaped the Future of the Combinatorial Chemistry Field; 3.1.3.1 Solid-Phase Synthesis; 3.1.3.2 Pooling Strategy; 3.1.3.3 Parallel Synthesis
3.2 Strategies in Combinatorial Solid-Phase Synthesis3.2.1 Random Split-and-Pool Method; 3.2.1.1 One-Bead-One-Compound Concept; 3.2.1.2 Encoding Methods for the OBOC Technique; 3.2.1.3 Organized Mixtures; 3.2.2 Directed Split-and-Pool Method in Practice; 3.2.2.1 Formulation of Solid-Phase Supports for the Directed Split-and-Pool Technique; 3.2.2.2 Chemical History of the Resin Formulations; 3.3 Equipment and Instrumentation; 3.3.1 Manual Solid-Phase Synthesis; 3.3.2 Integrated Semiautomated Synthesis; 3.3.3 Fully Automated Synthesizers (Gone with the Wind); 3.3.4 Instruments for Sorting
3.4 Characterization and Purification
Sommario/riassunto: Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications,
Titolo autorizzato: Solid-phase organic synthesis  Visualizza cluster
ISBN: 1-283-40957-7
9786613409577
1-118-14163-6
1-118-14164-4
1-118-14162-8
Formato: Materiale a stampa
Livello bibliografico Monografia
Lingua di pubblicazione: Inglese
Record Nr.: 9910141164703321
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