Current and Future Advances in Male Infertility : A Compendium for Clinicians and Researchers

• Autore: Agarwal Ashok
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (405 pages)
• Altri autori: SalehRamadan BoitrelleFlorence ShahRupin
• Nota di contenuto: Intro -- Foreword -- Preface -- Contents -- About the Editors -- Part I: Declining Male Reproductive Health -- Chapter 1: Clinical Implications of the WHO 6th Edition on Human Semen Analysis -- Introduction -- Sperm Analysis as Part of the Initial Workup for Infertile Couples -- Basic Sperm Parameters -- Extended Examination -- Multiple Sperm Defect Indices -- Sperm DNA Fragmentation -- Sperm Fluorescence In Situ Hybridization (FISH) -- Leukocytospermia -- Anti-sperm Antibodies (ASAs) -- Seminal Biochemistry -- Ejaculate Fraction -- Advanced Tests -- Seminal Oxidative Stress -- Acrosome Reaction -- Sperm Chromatin Condensation -- Transmembrane Ion Flow -- CASA Systems -- Conclusion -- References -- Chapter 2: Endocrine-Disrupting Chemicals (EDCs) and Male Infertility -- Introduction -- Endocrine-Disrupting Chemicals (EDCs) -- Polychlorinated Biphenyls (PCBs) -- Dichlorodiphenyltrichloroethane (DDT) and Its Main Metabolite (DDE) -- Bisphenol A (BPA) -- Phthalates (DBP, DEHP) -- EDCs and Semen Quality -- Mechanism(s) of Action on EDCs on the Male Reproductive System -- Disorders Associated with EDCs in the Male -- Cryptorchidism -- Hypospadias -- Testicular Cancer -- Transgenerational Effects of EDCs -- Epigenetic Alterations to the Fetus -- Genetic Disruptions of Spermatogenesis -- Limitations of Research on EDCs -- Future Research on EDCs and Male Infertility -- Summary -- References -- Chapter 3: Lifestyle Modifications and Male Infertility -- Introduction -- Lifestyle Factors Affecting Male Infertility -- Obesity -- Diet -- Smoking -- Alcohol Consumption -- Caffeine -- Performance-Enhancing Drug Usage -- Recreational Substance Abuse -- Sport/Physical Activity -- Electromagnetic/Radiofrequency Exposure -- Heat Stress -- Psychological Stress and Anxiety -- Mechanisms by Which Lifestyle Factors Affect Male Fertility -- Seminal Oxidative Stress. ; Direct Testicular Toxicity -- Germ Cell Changes -- Histopathological Changes -- Hormonal Mechanisms -- Nutritional Imbalances -- Genetic Mechanisms -- Effects of Lifestyle Changes on Semen Quality and Male Fertility -- Conclusion -- References -- Chapter 4: Impact of Testicular Cancer on Male Fertility -- Introduction -- Mechanisms of Infertility in TC -- Direct Parenchymal Damage and Replacement by the Tumor -- Correlative Etiologies -- Cryptorchidism -- Testicular Dysgenesis Syndrome -- Causative Mechanisms -- Endocrine Disruption and Hypogonadism -- Systemic Inflammation due to TC -- Antisperm Antibodies -- Elevated DNA Fragmentation -- Prior to the Treatment with Chemotherapy and/or Radiation Therapy -- Posttreatment with Radiation Therapy and/or Chemotherapy -- Relationship of Testicular Cancer Treatment and Infertility -- Orchidectomy/RPLND and Fertility -- Chemotherapy and Fertility -- Radiation Therapy and Fertility -- Sexual Dysfunction in Survivors of TC -- Contraception During Treatment: Paternity After Treatment -- Summary -- References -- Part II: Sperm Chromatin Integrity and Fertility -- Chapter 5: Impact of Sperm DNA Fragmentation on Natural and Assisted Conception -- Introduction -- Sperm DNA Natural Repair Mechanisms -- Origin of SDF -- Defective Sperm Chromatin Packaging -- Abortive Apoptosis -- Oxidative Stress-Mediated Damage -- Types of SDF -- What Causes SDF? -- Impact of SDF on Fertility Outcome -- Spontaneous Pregnancy Outcomes -- Outcomes of Assisted Reproductive Techniques -- Selecting a Test for SDF Evaluation -- Terminal Deoxynucleotidyl Transferase-Mediated Deoxyuridine Triphosphate Nick End Labeling (TUNEL) Assay -- Sperm Chromatin Structure Assay (SCSA) -- Sperm Chromatin Dispersion (SCD) Test -- Comet Assay -- Implementing SDF Test into Clinical Practice -- The SDF Test in the WHO Manual of Semen Analysis. ; The SDF Test in the Guidelines of Professional Societies -- Limitations of SDF Test -- Strategies to Reduce SDF -- Limiting Exposures and Lifestyle Change -- Control of Male Genital Tract Infections/Inflammation -- Varicocele Repair -- Antioxidant Supplementation -- Management of Persistently High SDF -- Use of Testicular Sperm -- Use of Sperm Selection Techniques -- Summary -- References -- Part III: Male Oxidative Stress Infertility (MOSI) -- Chapter 6: Pathophysiology of Seminal Oxidative Stress -- Introduction -- Role of Reactive Oxygen Species and Oxidative Stress in Male Infertility -- The Physiological Role of ROS in Sperm Cells -- Maturation -- Capacitation -- Acrosome Reaction -- Sperm-Oocyte Fusion -- Pathological Role of ROS in Sperm Cells -- Lipid Peroxidation -- Sperm DNA Fragmentation -- Apoptosis -- Mitochondrial Dysfunction -- ROS Sources in Seminal Plasma -- Redox Status in Semen -- Methods to Assess Redox Status -- Redox Biomarkers of Male Infertility -- Treatment of OS-Related Male Infertility -- Insights into Future Redox Biomarker Research -- Summary -- References -- Chapter 7: Management of Male Oxidative Stress Infertility (MOSI) -- Introduction -- Causes of OS and Male Infertility -- Intrinsic Causes -- Extrinsic Causes -- Diagnosis of MOSI -- Semen Analysis -- ROS Assays -- Total Antioxidant Capacity -- ROS-TAC Score -- Oxidative Reduction Potential -- Treatment of Male Oxidative Stress Infertility -- Empiric Medical Therapy -- Antioxidants -- Arginine -- Carnitines -- Coenzyme Q10 -- Folic Acid -- Glutathione -- Lycopene -- Selenium -- Vitamin A -- Vitamin C -- Vitamin E -- Zinc -- Lifestyle and Dietary Modification -- Obesity -- Antibiotics -- Varicocele Repair -- New Strategies -- Summary -- References -- Part IV: Genetics and Epigenetics of Male Infertility -- Chapter 8: Advances in Genetics of Male Infertility. ; Introduction -- Chromosomal Alterations -- Epigenetic Factors -- Advances in Genetic Testing for Male Infertility -- Chromosomal Alteration Testing -- Gene Panel Testing and Next-Generation Sequencing Approaches -- Impact of Genetic Mutations on Male Infertility Management -- Congenital Hypogonadotropic Hypogonadism (cHH) -- Congenital Absent Vas Deferens (CAVD) -- Teratozoospermia and Asthenozoospermia -- Impaired Sperm Capacitation and Fertilizing Capacity -- Quantitative Spermatogenic Disturbances -- Gene Therapy -- Conclusion -- References -- Chapter 9: Epigenetic Alterations in Male Infertility -- Narrative Review -- Introduction -- Epigenetic Mechanisms -- DNA Methylation (CpG Sites) -- Histone Modification -- Chromatin Remodelling -- Small Non-coding RNAs -- Epigenetics and Sperm -- Epigenetics in Spermatogenesis -- Factors Contributing to Epigenetic Changes in Sperm -- Techniques to Assess Sperm Epigenetics -- Epigenetic Alterations in Male Infertility -- Impact on Fertility -- Impact on Semen Parameters -- Impact on ART Outcomes -- Epigenetic Inheritance and Impact on Offspring Health -- Insights into the Future Research of Epigenetic Alterations in Male Infertility -- SWOT (Strengths, Weaknesses, Opportunities and Threats) Analysis of the Current Research on Epigenetics -- Prospects for Future Research on Epigenetics -- Summary -- References -- Part V: Varicocele Revisited -- Chapter 10: New Insights into the Pathophysiology of Varicocele in Male Infertility -- Introduction -- Animal Models to Study the Pathophysiology of Varicoceles -- Laboratory Finding Associated with the Pathophysiology of Varicoceles -- Anatomic Hypotheses of Origin of Varicoceles -- Scrotal Hyperthermia -- Hormonal Disturbances -- Hypoperfusion of the Testis -- Metabolic Reflux to the Testis -- Genetics of Varicocele Pathophysiology -- Sperm Proteomics. ; Effect of Varicocele on Testicular Function -- Varicocele and Conventional Semen Analysis -- Varicocele and Oxidative Stress -- Varicocele and Antisperm Antibodies -- Varicocele and Sperm Vitality -- Varicocele and Sperm Capacitation -- Varicocele and Sperm Binding to Zona Pellucida -- Varicocele and Sperm DNA Fragmentation -- Summary -- References -- Chapter 11: Clinical Dilemmas and Controversies in Varicocele Management -- Controversies in Diagnosis -- Clinical Versus Ultrasonographic Diagnosis and Grading -- Guidelines for Varicocele Diagnosis -- Controversies in Counseling -- Evaluating the Real Impact of Varicocele on Male Fertility -- Clinical Varicocele in the Context of Normal Conventional Semen Parameters -- Role of Varicocele Repair (VR) in the Context of ART -- Varicocele and Hypogonadism -- Varicocele and NOA -- Varicocele in Adolescence -- Varicocele and Scrotal Pain -- Controversies in Therapy -- Indications for Intervention -- Other Indications -- Elevated SDF -- Prior to ART -- NOA and Prior to Sperm Retrieval -- Hypogonadism -- Intervention: Which Technique to Select? -- Reference Technique (Subinguinal Microsurgical Varicocelectomy) -- Subclinical Varicocele: To Treat or Not to Treat? -- Bilateral Versus Unilateral VR -- Age of the Couple -- Role of Medical and AOX-Based Therapy -- Controversies in Posttreatment Evaluation -- Role of Ultrasound in Post-VR Evaluation -- Optimal Duration to Assess Post-VR Changes in Semen Parameters -- Managing Recurrent and Persistent Varicocele -- Future Perspectives -- Clinical Case Scenario -- Answer -- Clinical Case Scenario 2 -- Answer -- Summary -- References -- Part VI: Management of Male Accessory Gland Infection (MAGI) -- Chapter 12: Challenges in the Diagnosis and Treatment of Male Accessory Gland Infection (MAGI) -- Introduction -- Microbiological Investigations in MAGI. ; Diagnostic Workup of MAGI.
• Titolo autorizzato: Current and Future Advances in Male Infertility
• ISBN: 3-031-62648-6
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910878974203321
• Lo trovi qui: Univ. Federico II