Immunity to parasitic infections / / edited by Tracey Lamb

• Pubblicazione: Chichester, West Sussex, U.K., : John Wiley & Sons, 2012
• Descrizione fisica: 1 online resource (518 p.)
• Disciplina: 616.9/6071
• Soggetto topico: Parasitic diseases; Immune system - Physiology; Parasitic diseases - Treatment
• Altri autori: LambTracey
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Immunity to Parasitic Infection; Contents; List of Contributors; Introduction Immunoparasitology: the making of a modern immunological science; Origins; Development of immunoparasitology as an experimental science; The immunological renaissance; Early breakthroughs and disappointments in parasite vaccine development; Effector mechanisms and effector choice in parasitic infection; Parasites define roles for regulatory T cells; Parasites help define the roles of regulatory cytokines and the plasticity of CD4+ T cell subsets; Parasites as triggers of the innate immune response ; Lessons from helminth immunology about allergic and fibrotic diseaseReturning from mouse to man; Andrade's challenge and the future of immunoparasitology; Acknowledgments; REFERENCES FOR FURTHER READING; Section 1; 1 Notes on the Immune System; 1.1 The immune system; 1.2 Innate immune processes; 1.2.1 Inflammation; 1.2.2 The acute phase response; 1.2.3 Anti-microbial peptides; 1.3 The complement cascade; 1.4 Innate recognition; 1.5 Pattern recognition receptors; 1.5.1 Signalling events activated upon ligation of PRRs; 1.6 Innate immune cells; 1.6.1 Macrophages; 1.6.2 Granulocytes ; 1.6.3 Dendritic cells1.6.4 Natural killer (NK) cells; 1.7 Communication in the immune system; 1.8 Adaptive immunity; 1.9 The role of the MHC in the immune response; 1.10 T cell activation and cellular-mediated immunity; 1.10.1 Three signals are required for CD4+ T cell activation; 1.10.2 Cross-presentation and cross-priming of CD8+ T cells; 1.10.3 CD4+ T cell phenotypes; 1.10.4 Other T cells of the innate immune system; 1.11 B cells and the humoral response; 1.11.1 B cell activation against T-dependent antigens; 1.11.2 Antibody isotypes; 1.11.3 Fc receptor recognition via Fc receptors ; 1.12 Cell trafficking around the body1.13 Cellular immune effector mechanisms; 1.13.1 Phagocytosis and pathogen digestion; 1.13.2 Cellular-mediated lysis of pathogens; 1.13.3 Granuloma formation as a method of containment; 1.14 Hypersensitivity reactions; 1.14.1 Type 1 hypersensitivity reactions (immediate); 1.14.2 Type 2 hypersensitivity reaction (immediate); 1.14.3 Type 3 hypersensitivity reactions (immediate); 1.14.4 Type 4 hypersensitivity reaction (delayed); REFERENCES FOR FURTHER READING; Section 2; 2 Introduction to Protozoan Infections; 2.1 The protozoa; 2.2 Amoebozoa ; 2.2.1 Entamoebidae2.2.2 Entamaoba histolytica; 2.3 Excavata; 2.3.1 Metamonad,Diplomonadida; 2.3.2 Metamonad, Parabasalia; 2.3.3 Discoba,Euglenozoa; 2.4 Harosa; 2.4.1 Aveolata; 2.5 Protozoa that are now fungi; 2.6 Taxonomy and the evolution of the parasitic protozoa; 2.7 Genomic and post genomic exploration of protozoan biology; 2.8 Summary; 2.9 General information on protozoa; REFERENCES FOR FURTHER READING; 3 Apicomplexa: Malaria; 3.1 Malaria; 3.1.1 The life cycle of malaria; 3.1.2 Mouse models of malaria; 3.2 Recognition of malaria parasites; 3.3 Innate effector mechanisms ; 3.3.1 Pre-erythrocytic stages
• Sommario/riassunto: "Parasitic infections remain a significant cause of morbidity and mortality in the world today. Often endemic in developing countries many parasitic diseases are neglected in terms of research funding and much remains to be understood about parasites and the interactions they have with the immune system. This book examines current knowledge about immune responses to parasitic infections affecting humans, including interactions that occur during co-infections, and how immune responses may be manipulated to develop therapeutic interventions against parasitic infection. For easy reference, the most commonly studied parasites are examined in individual chapters written by investigators at the forefront of their field. An overview of the immune system, as well as introductions to protozoan and helminth parasites, is included to guide background reading. A historical perspective of the field of immunoparasitology acknowledges the contributions of investigators who have been instrumental in developing this field of research"--Provided by publisher.
• Titolo autorizzato: Immunity to parasitic infections
• ISBN: 1-118-39332-5; 1-118-39333-3; 1-283-55044-X; 9786613862891; 1-118-39334-1
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910877408003321
• Lo trovi qui: Univ. Federico II