Asymmetric dearomatization reactions / / edited by Shu-Li You

• Pubblicazione: Weinheim, Germany : , : Wiley-VCH, , 2016; 2016
• Descrizione fisica: 1 online resource (422 p.)
• Disciplina: 541.395
• Soggetto topico: Catalysis; Chemistry
• Soggetto non controllato: Chemical Reactions; Chemistry; Aromatic Compounds; Science
• Persona (resp. second.): YouShu-Li
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references at the end of each chapters and index.
• Nota di contenuto: Cover; Title Page; Copyright; Contents; List of Contributors; Preface; Chapter 1 Introduction; 1.1 Why Asymmetric Dearomatization Reactions?; 1.2 Discovery of Aromatic Compounds and Dearomatization Reactions; 1.3 Development of Dearomatization Reactions; 1.4 Asymmetric Dearomatization Reactions; References; Chapter 2 Asymmetric Dearomatization with Chiral Auxiliaries and Reagents; 2.1 Introduction; 2.2 Chiral -Bound Auxiliaries; 2.2.1 Oxazolines; 2.2.2 Imines, Oxazolidines, and Hydrazones; 2.2.3 Chiral Ethers and Amines; 2.3 Diastereospecific Anionic Cyclizations; 2.4 Use of Chiral Reagents ; 2.4.1 Chiral Bases in Dearomatizing Cyclizations2.4.2 Chiral Nucleophiles; 2.4.3 Chiral Ligands in Enantioselective Nucleophilic Additions; 2.5 Chiral -Complexes; 2.5.1 Planar Chiral 6-Arene Complexes; 2.5.2 6-Arene Complexes with a Chiral Ligand; 2.5.3 Complexes with Stereogenic Metal Centers; 2.6 Conclusion; References; Chapter 3 Organocatalytic Asymmetric Transfer Hydrogenation of (Hetero)Arenes; 3.1 Introduction; 3.2 Organocatalytic Asymmetric Transfer Hydrogenation of Heteroaromatics; 3.2.1 Quinolines; 3.2.1.1 Proof-of-Concept; 3.2.1.2 2-Substituted Quinolines ; 3.2.1.3 4-Substituted Quinolines3.2.1.4 3-Substituted Quinolines; 3.2.1.5 2,3-Disubstituted Quinolines; 3.2.1.6 Spiro-Tetrahydroquinolines; 3.2.2 Benzoxazines, Benzothiazines, and Benzoxazinones; 3.2.3 Benzodiazepines and Benzodiazepinones; 3.2.4 Pyridines; 3.2.5 3H-Indoles; 3.2.6 Quinoxalines and Quinoxalinones; 3.3 Organocatalytic Asymmetric Transfer Hydrogenation in Aqueous Solution; 3.4 Cascade Reactions; 3.4.1 Introduction; 3.4.2 In situ Generation of the Heteroarene; 3.4.3 Dearomatization of Pyridine/Asymmetric aza-Friedel-Crafts Alkylation Cascade ; 3.4.4 Combining Photochemistry and Brønsted Acid Catalysis3.4.4.1 Quinolines; 3.4.4.2 Pyrylium ions; 3.5 Cooperative and Relay Catalysis: Combining Brønsted Acid- and Metal-Catalysis; 3.5.1 Introduction; 3.5.2 Improvements in Transfer Hydrogenation; 3.5.2.1 Regenerable Hydrogen Sources; 3.5.2.2 Asymmetric Relay Catalysis (ARC); 3.5.3 Cooperative Metal-Brønsted Acid Catalysis; 3.6 Summary and Conclusion; References; Chapter 4 Transition-Metal-Catalyzed Asymmetric Hydrogenation of Aromatics; 4.1 Introduction; 4.2 Catalytic Asymmetric Hydrogenation of Five-Membered Heteroarenes ; 4.2.1 Catalytic Asymmetric Hydrogenation of Azoles and Indoles4.2.1.1 Rhodium-Catalyzed Asymmetric Hydrogenation of Indoles; 4.2.1.2 Ruthenium-Catalyzed Asymmetric Hydrogenation of Azoles; 4.2.1.3 Palladium-Catalyzed Asymmetric Hydrogenation of Azoles; 4.2.1.4 Iridium-Catalyzed Asymmetric Hydrogenation of Indoles; 4.2.2 Catalytic Asymmetric Hydrogenation of Oxygen-Containing Heteroarenes; 4.2.3 Catalytic Asymmetric Hydrogenation of Sulfur-Containing Heteroarenes; 4.3 Catalytic Asymmetric Hydrogenation of Six-Membered Heteroarenes; 4.3.1 Catalytic Asymmetric Hydrogenation of Azines ; 4.3.1.1 Iridium-Catalyzed Asymmetric Hydrogenation of Pyridines
• Sommario/riassunto: Annotation The first comprehensive account of the rapidly growing field of asymmetric dearomatization reactions with a focus on catalytic methods. It introduces the concept of dearomatization and describes recent progress in asymmetric reaction procedures with different catalyst systems, such as organocatalysts, transition metal catalysts, and enzymes. Chapters on dearomatizations of electron-deficient aromatic rings, dearomatization reactions via transition metal-catalyzed cross-couplings as well as dearomatization strategies in the synthesis of complex natural products are also included. Written by pioneers in the field, this is a highly valuable source of information not only for professional synthetic chemists in academia and industry but also for all those are interested in asymmetric methodologies and organic synthesis in general.
• Titolo autorizzato: Asymmetric dearomatization reactions
• ISBN: 3-527-69848-5; 3-527-69846-9; 3-527-69847-7
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830798503321
• Lo trovi qui: Univ. Federico II