Novel infectious agents and the central nervous system [[electronic resource]]

• Pubblicazione: Chichester ; ; New York, : Wiley, 1988
• Descrizione fisica: 1 online resource (290 p.)
• Disciplina: 616.8; 616.83
• Soggetto topico: Central nervous system - Diseases - Etiology; Scrapie; Prions
• Note generali: "A Wiley-Interscience publication."; Papers and discussions from the Symposium on Novel Infectious Agents and the Central Nervous System, held at the Ciba Foundation, London, June 30-July 2, 1987.
• Nota di bibliografia: Includes bibliographies and indexes.
• Nota di contenuto: NOVEL INFECTIOUS AGENTSANDTHE CENTRAL NERVOUS SYSTEM; Contents; Participants; Introduction; The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases; Neuropathology of unconventional virus infections: molecu lar pathology of spongiform change and amyloid plaque deposit ion; Pathogenesis of experimental scrapie; Genetic aspects of unconventional virus infections: the basis of the virino hypothesis; Genetic control of prion incubation period in mice; Developmental regulation of prion protein mRNA in brain ; Potential involvement of retroviral elements in human dementiasScrapie: a virus-induced amyloidosis of the brain; Scrapie-associated fibrils, PrP protein and the Sinc gene; A modified host protein model of scrapie; Properties of scrapie prion proteins in liposomes and amyloid rods; In vitro expression of cloned PrP cDNA derived from scrapie-infected mouse brain: lack of transmission of scrapie infectivity; Search for a scrapie-specific nucleic acid: a progress report; Pathogenesis of amyloid formation in Alzheimer's disease, Down's syndrome and scrapie ; Novel mechanisms of degeneration of the central newous system - prion structure and biologyFinal general discussion; Summary; Index of contributors; Subject index
• Sommario/riassunto: The term ``unconventional virus'' refers to virus-like agents that differ from conventional viruses in significant respects--resistance to agents that inactivate normal viruses, for example. Certain rare and fatal neurological disorders, such as the Creutzfeldt-Jacob syndrome and the Gerstmann-Straussler syndrome, are clearly produced by virus-like infectious agents, but the nature of these agents is not understood. This volume brings together the latest information on one such disease: Scrapie, a disease occurring in sheep. It discusses the nature of this infectious agent and insights gained
• Titolo autorizzato: Novel infectious agents and the central nervous system
• ISBN: 1-282-34597-4; 9786612345975; 0-470-51361-6; 0-470-51362-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910830012003321
• Lo trovi qui: Univ. Federico II
• Serie: Ciba Foundation symposium ; ; 135.