Golgi apparatus [[electronic resource] ] : structure, functions and mechanisms / / Christopher J. Hawkins, editor

• Pubblicazione: New York, : Nova Science Publishers, c2011
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (181 p.)
• Disciplina: 571.6/56
• Soggetto topico: Golgi apparatus; Protoplasm
• Altri autori: HawkinsChristopher J
• Note generali: Description based upon print version of record.
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- GOLGI APPARATUS STRUCTURE, FUNCTIONS AND MECHANISMS -- GOLGI APPARATUS STRUCTURE, FUNCTIONS AND MECHANISMS -- CONTENTS -- PREFACE -- Chapter 1 GOLGI ORGANIZATION AND STRESS SENSING -- ABSTRACT -- 1. INTRODUCTION -- 2. GOLGI STRUCTURE -- 2.a. The Intricacies of the Mammalian Golgi Apparatus -- 2.b. Golgi Ribbon Structure and Interaction with Other Organelles -- 2.c. Golgi Structure and Stacking -- 2.d. The Cytoskeleton and Maintenance of Golgi Ribbon Structure -- 2.d.1. Microtubules Maintain Golgi Ribbon Structure -- 2.d.2. The Actin Cytoskeleton and Golgi Structure -- 2.e. Contribution of Lipids to Golgi Structure and Function -- 2.e.1. Importance Of Glycerophospholipids In Golgi Structure And Function -- 2.e.2. Role of Sphingolipids and Lipid Transfer Proteins in Golgi Structure and Function -- 2.e.2.1. CERT and Stabilization of ER-Golgi Contact Sites -- 2.e.2.2. Role of FAPP2 and Transport of GlcCer Within the Golgi Apparatus -- 2.e.2.3. OSBP, Cholesterol Sensing and Maintainence of ER-Golgi Contact Sites -- 2.e.2.4. Sphingomyelin and CERT Function in Flies and Mammals -- 3. APOPTOSIS AND GOLGI STRUCTURAL ORGANIZATION -- 3.a. The Cellular Machinery for Apoptosis -- 3.b. Ceramide Mediated Apoptosis And Golgi Ribbon Architecture -- 3.b.1. Ceramide Biosynthesis and Metabolism -- 3.b.2. Ceramide Regulation and Golgi Structure -- 3.b.3. Ceramide and Apoptosis -- 4. CELLULAR LOCATION OF THE GOLGI APPARATUS IN STRESS SENSING -- CONCLUSION -- REFERENCES -- Chapter 2 FUNCTIONAL RELATIONSHIPS BETWEEN GOLGI DYNAMICS AND LIPID METABOLISM AND TRANSPORT -- ABSTRACT -- ABBREVIATIONS -- 1. INTRODUCTION -- 2. LIPIDS AND PROTEINS INVOLVED IN MEMBRANE BUDDING -- 2.1. Adaptor/Clathrin-Coat Vesicle Formation at the Golgi -- 2.2. Formation of COPI Vesicles -- 2.3. Lipid Functions In Membrane Trafficking. ; 2.3.1. PtdOH, DAG, and Lyso-Phospholipids -- 2.3.1.1. PtdOH and DAG Synthesis and Interconversion -- 2.3.1.2. Roles for PtdOH and DAG in Vesicular Fission at the Golgi -- 2.3.1.3. Role of Lyso-PtdOH in Golgi Secretion -- 2.3.2. PtdIns-Polyphosphates -- 2.3.2.1. Roles of PtdInsP in Golgi Trafficking -- 2.3.2.2. PtdInsP Metabolism in the Golgi Apparatus -- 2.3.3. Cholesterol and Sphingolipids -- 2.3.3.1. Roles of the Golgi Apparatus in Cholesterol and Sphingolipid Homeostasis -- 2.3.3.2. Cholesterol Flux and Biosynthesis -- 2.3.3.3. Sphingolipid Biosynthesis -- 2.3.4. Lipid Transport Proteins Involved in Cholesterol and Sphingolipid Metabolism -- 2.3.4.1. Glycolipid Transfer by FAPP -- 2.3.4.2. Ceramide Transfer Protein -- 2.3.4.3. Golgi Cholesterol Transfer by OSBPs -- 3. PROTEINS INVOLVED IN MEMBRANE TETHERING AND FUSION -- 3.1. Vesicle Tethering at the Golgi -- 3.2. Vesicle Fusion Mediated by SNAREs -- 4. DISEASES RELATED TO LIPID METABOLISM AND GOLGI FUNCTION -- 4.1. Lowe Syndrome -- 4.2. Congenital Disorders of Glycosylation -- 4.3. Tangier Disease -- CONCLUSION -- REFERENCES -- Chapter 3 SIGNALING PATHWAYS CONTROLLING MITOTIC GOLGI BREAKDOWN IN MAMMALIAN CELLS -- ABSTRACT -- 1. INTRODUCTION -- 2. UNLINKING OF THE GOLGI RIBBON IN LATE G2 PHASE -- 3. GOLGI STACKS DISASSEMBLY AND VESICULATION -- 4. GOLGI APPARATUS INHERITANCE AND THE MITOTIC SPINDLE -- 5. GOLGI APPARATUS REASSEMBLY -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- Chapter 4 GOLGI APPARATUS AND HYPERICIN-MEDIATED PHOTODYNAMIC ACTION -- ABSTRACT -- 1. AN ALTERNATIVE THERAPEUTIC MODALITY: PHOTODYNAMIC THERAPY -- 2. A PROMISING SECOND-GENERATION PHOTOSENSITIVE DRUG: HYPERICIN -- 3. THE MECHANISMS OF HYPERICIN-MEDIATED PDT AND GOLGI APPARATUS'S ROLE -- ACKNOWLEDGMENTS -- REFERENCES. ; Chapter 5 ROLE OF THE TRANS-GOLGI NETWORK (TGN) IN THE SORTING OF NONENZYMIC LYSOSOMAL PROTEINS -- ABSTRACT -- I. EVOLUTIONARY SORTING SYSTEMS IN THE TGN -- II. THE FUNCTION OF LYSOSOMAL PROTEINS -- Overview -- Lysosomal Functions of Sphingolipid Activator Proteins (SAPs) -- III. SORTING OF LYSOSOMAL PROTEINS -- The Mannose-6-Phosphate Receptors (MPRs) -- Sortilin -- Adaptor Proteins - Overview -- Adaptor Proteins - Anterograde Transport -- Adaptor Proteins - Retrograde Transport -- IV. PROSAPOSIN TRAFFICKING -- Overview -- Sortilin-Mediated Sorting of Prosaposin -- Prosaposin Processing in the Golgi Apparatus -- Effect of Endo H Treatment -- Effect of Brefeldin A (BFA) Treatment -- Effects of Sequential Truncations of the Prosaposin C-Terminus -- V. GM2AP TRAFFICKING -- VI. THE ROLE OF LIPID RAFTS IN LYSOSOMAL TRAFFICKING -- VII. THE SORTILIN MODEL -- Inactivation of the Sortilin Gene -- VIII. SIGNIFICANCE OF THIS STUDY -- REFERENCES -- Chapter 6 GOLGI APPARATUS FUNCTIONS IN MANGANESE HOMEOSTASIS AND DETOXIFICATION -- ABSTRACT -- INTRODUCTION -- METHODS -- Cell Culture -- Treatment and Sample Preparation for Nano-Imaging -- Synchrotron X-Ray Fluorescence Nano-Imaging -- Golgi Apparatus Labeling -- RESULTS -- DISCUSSION -- Manganese Accumulation in GA -- Role of GA in Mn Detoxification -- Manganese Alteration of GA and Neurodegenerative Diseases -- CONCLUSION -- ACKNOWLEDGMENTS -- REFERENCES -- INDEX -- Blank Page.
• Titolo autorizzato: Golgi apparatus
• ISBN: 1-61122-611-2
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910807386303321
• Lo trovi qui: Univ. Federico II
• Serie: Cell Biology Research Progress