Exploring Drug Delivery to the Peritoneum

• Autore: Shegokar Ranjita
• Pubblicazione: Cham : , : Springer International Publishing AG, , 2024; ©2023
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (244 pages)
• Disciplina: 616.38061
• Soggetto topico: Peritoneum; Peritoneal Cavity; Drug Delivery Systems; Nanoparticle Drug Delivery System
• Nota di contenuto: Intro -- Preface -- Acknowledgments -- Contents -- Peritoneal Organ-Anatomical and Physiological Considerations -- 1 Introduction -- 1.1 Developmental Considerations -- 1.2 Extraperitoneal Tissue -- 1.3 Anatomy of the Peritoneum -- 1.4 Peritoneal Cavity and Recesses -- 1.5 Physiology of Peritoneal Fluid -- 1.6 Splanchnic Circulation: Blood Supply, Venous Drainage, and Lymphatic Drainage -- 1.7 Innervation -- 1.8 Functional Correlations -- 1.9 Peritoneum in Herniorrhaphy -- 1.10 Peritonitis -- 1.11 Peritoneal Dialysis -- 2 Conclusion -- References -- Intraperitoneal Delivery Systems -- 1 Introduction -- 2 History of Intraperitoneal Delivery Systems -- 3 Principles of Intraperitoneal Delivery Systems -- 3.1 Criteria of Intraperitoneal Drug Delivery Systems -- 4 Methods of Intraperitoneal Delivery (IPD) -- 4.1 Direct Injection/Conventional IP Drug Delivery -- 4.2 Continuous Infusion/Implantable IP Drug Delivery Systems -- 5 Drugs for Intraperitoneal Delivery Systems -- 6 Conclusion -- References -- Liposomes and Lipid Nanoparticles as Peritoneal Drug Delivery Systems -- 1 Introduction -- 2 Anatomy and Physiology of the Peritoneum -- 3 Plura and Peritoneal Drug Delivery Systems -- 4 Lipid-Based Nanoparticles as Peritoneal Drug Delivery: Status and Advances -- 5 Different Types of Liposomes and Lipid Nanoparticles -- 5.1 Liposomes -- 5.2 Solid Lipid Nanoparticles -- 5.3 Nanostructured Lipid Carriers -- 5.4 Nanoemulsions -- 5.5 Exosomes -- 5.6 Lipid Polymer Hybrid Nanoparticles -- 6 Lipid-Drug Conjugate -- 7 Peritoneal Targeting by Nanocarriers -- 8 Cell and Molecular Biology of Peritoneal Drug Delivery -- 9 Clinical Status -- 10 Conclusion -- References -- Nano- and Micromedicines as Intraperitoneal Therapy in Ovarian Cancer: Critical Overview and Focus on Pharmaceutical Manufacturing Under cGMP -- 1 Introduction. ; 1.1 Ovaries: Anatomy, Physiology, and Carcinogenesis -- 1.2 Diagnosis and Epidemiology -- 2 State-of-the-art of Ovarian Cancer Therapies -- 3 Intraperitoneal Route: Characteristics -- 4 Innovative Therapeutic and Diagnostic Tools -- 4.1 Nano- and Microparticles for Intraperitoneal Ovarian Cancer Treatment -- 4.2 Efforts on Nano- and Microparticles Nanomanufacturing -- 5 Conclusion -- References -- Pressurized Intraperitoneal Aerosolized Chemotherapy (PIPAC): Promising Strides from India -- 1 Introduction -- 2 The Burden of Peritoneal Surface Malignancy -- 3 The Evolution of Peritoneal Surface Oncology in India -- 4 Evidence from India Regarding PIPAC -- 4.1 The Initial Experiences -- 4.2 Drug Safety and Efficacy Studies -- 4.3 PIPAC for Ovarian Origin PM -- 4.4 PIPAC for Appendicular Origin PM -- 4.5 PIPAC for Colorectal Origin PM -- 4.6 PIPAC for Gastric Origin PM -- 5 The Indian Healthcare Structure and Its Influence on PIPAC -- 5.1 Treatment Costs -- 5.2 Referral Patterns and Patient Attitudes -- 6 Adaptation of PIPAC Among Clinicians -- 7 Technological Limitations of PIPAC -- 8 Future Directions -- 9 Conclusion -- References -- HIPEC: Concept and Fundamentals in Colorectal Cancer Peritoneal Metastasis Treatment -- 1 Introduction -- 2 Peritoneal Cancer Index -- 3 Eindhoven Index Regimens -- 4 HIPEC Contraindications -- 5 HIPEC Mechanisms and Role of the Temperature -- 6 Types of HIPEC -- 7 HIPEC Procedure -- 8 1st Stage of a HIPEC Procedure -- 9 2nd Stage of a HIPEC Procedure -- 10 3rd Stage of a HIPEC Procedure -- 11 Last Stage of a HIPEC Procedure -- 12 Final Assessment of Classic HIPEC for Colorectal Cancer Peritoneal Metastasis -- 13 Futuristic Electro - HIPEC -- 14 Conclusion -- References -- Peritoneal Implants and Drug Delivery -- 1 Introduction -- 2 Physiological and Anatomical Considerations -- 3 Permeation Through Peritoneal Membrane. ; 4 Drug Delivery Implants -- 4.1 Intraperitoneal Injection -- 4.2 Nanocarriers -- 4.3 Liposomes -- 4.4 Hydrogels -- 4.5 Nanofibers -- 4.6 3D Printed Thermosensitive Disks and Thermosensitive Sol-Gels -- 4.7 Nanotextiles -- 5 Methodologies for Evaluating Peritoneal Depots -- 5.1 Particle Size and Entrapment Efficiency -- 5.2 In Vitro Drug Release -- 5.3 Permeation Studies -- 5.4 Microscopy -- 5.5 Fluorescent Testing -- 5.6 Peritoneal Concentration and Pharmacokinetic Estimation -- 6 Peritoneal Depot Portal as Therapeutic Alternative -- 7 Conclusion -- References -- Importance of Computational Models in the Development of Intraperitoneal Administration-Based Drug Delivery Systems for Solid Tumors -- 1 Introduction -- 2 Transport Mechanisms in IP Drug Delivery -- 3 Different Barriers against IP Delivery -- 4 Computational Models -- 4.1 Compartment Models -- 4.2 Spatiotemporal Distribution Models -- 4.2.1 Interstitial Fluid Flow -- 4.2.2 Mass Transport -- 4.2.3 Geometry -- 4.3 Cell-Based Model -- 5 Nanoparticles in Intraperitoneal Chemotherapy -- 5.1 Magnetic Nanoparticle-Based IP Chemotherapy -- 5.2 Thermosensitive Liposome-Mediated IP Chemotherapy -- 6 Discussion and Concluding Remarks -- Abbreviations -- References -- Drug Delivery Systems to the Peritoneum: Current Status and Future Perspectives -- 1 Drug Delivery: Overview -- 2 Anatomy of Peritoneal Cavity and Membrane -- 3 Malignancies in Peritoneal Cavity and Current Therapy -- 4 Intraperitoneal Drug Administration -- 5 Types of Peritoneal Drug Delivery Systems -- 5.1 Microspheres -- 5.2 Nanoparticles -- 5.3 Liposomes -- 5.4 Micelles -- 5.5 Injectable System -- 5.6 Implantable System -- 6 Preclinical Studies -- 6.1 In-Vitro Model -- 6.2 In-Vivo Animal Model -- 6.3 Human Clinical Studies -- 7 Toxicity -- 8 Regulatory Guidelines -- 8.1 Material and Manufacturing -- 8.2 Safety -- 8.3 Efficacy. ; 8.4 Pharmacokinetic-Pharmacodynamic Correlation -- 9 Pharmacokinetic of Peritoneal Drug Delivery -- 10 Advantages of Peritoneal Drug Delivery -- 11 Future Perspectives on IP Drug Delivery Systems -- 12 Conclusion -- References -- Exploring the Intraperitoneal Route in a New Way for Preclinical Testing -- 1 Introduction -- 2 History of IP Drug Delivery -- 3 The Peritoneum: Anatomy and Histophysiology -- 4 Circulation Dynamics of Peritoneum -- 5 Gross and Histopathology of Peritoneum -- 6 Pharmacokinetics of the Drug Given Intraperitoneally -- 7 Factors Influencing Preclinical IP Route Drug Delivery -- 7.1 The Type of Drugs Used -- 7.2 The Dose of Drug Used -- 7.3 The Volume of Drug -- 7.4 Intra-abdominal Pressure -- 7.5 Hyperthermia -- 7.6 Vehicle Used -- 7.7 Type of Carrier Solutions (Hydrophilic vs Lipophilic) -- 8 Animal Models of IP Drug Delivery -- 9 Conclusion -- References -- Index.
• Titolo autorizzato: Exploring Drug Delivery to the Peritoneum
• ISBN: 3-031-31694-0
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910767503803321
• Lo trovi qui: Univ. Federico II