Senotherapy : A Potential Pharmacological Strategy for Prolonging Human Lifespan and Healthspan

• Autore: Bennett Gabriel
• Pubblicazione: Singapore : , : Springer, , 2024; ©2024
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (113 pages)
• Nota di contenuto: Intro -- Statement About the Usage of Artificial Intelligence -- Contents -- About the Author -- Abbreviations -- List of Figures -- Chapter 1: Introduction to Senotherapies -- 1.1 Hallmarks of Biological Ageing -- 1.2 Senescent Cells and Age-Associated Diseases -- 1.2.1 Senescent Cell Accumulation -- 1.2.2 Increased Amounts of SASPs Contribute to Senescent Cell Development -- 1.3 Senotherapeutics: Treating Senescent Cells -- 1.3.1 An Introduction to Senotherapeutics -- 1.3.2 Senolytics -- 1.3.3 Senomorphics -- 1.4 Relevance of This Book to the Modern Perspectives on Disability Research SpringerBrief Series -- 1.5 Intended Audience of This Book -- 1.6 Pedagogical Features of This Book -- 1.7 Description of Upcoming Chapters -- 1.7.1 Chapter 2: The Accumulation of Senescent Cells and Disease -- 1.7.2 Chapter 3: Current Research About Senotherapeutics -- 1.7.3 Chapter 4: Final Comments -- Further Reading -- References -- Chapter 2: The Accumulation of Senescent Cells and Diseases -- 2.1 Causational Relationship Between Senescent Cell Accumulation and Age-Associated Diseases -- 2.1.1 Type 2 Diabetes -- 2.1.2 Type 1 Diabetes -- 2.1.3 Idiopathic Pulmonary Fibrosis (IPF) -- 2.1.4 Viral Infections -- 2.1.5 Ophthalmic Diseases -- 2.1.6 Multiple Sclerosis -- 2.1.7 Parkinson's Disease -- 2.1.8 Obesity-Related Diseases -- 2.1.9 Non-alcoholic Fatty Liver Disease (NAFLD) -- 2.1.10 Non-alcoholic Steatohepatitis (NASH) -- 2.1.11 Periodontitis -- 2.2 Conclusion -- Further Reading -- References -- Chapter 3: Current Research About Senotherapeutics -- 3.1 Senolytic Potential of Dasatinib and Quercetin (D + Q) -- 3.1.1 Learning and Memory -- 3.1.2 Reduced Adipose Tissue Inflammation and Improved Systemic Metabolic Function -- 3.1.3 Muscle Wasting in Chronic Kidney Disease (CKD) -- 3.1.4 Age-Dependent Intervertebral Disc Degeneration. ; 3.1.5 Non-alcoholic Fatty Liver Disease (NAFLD) -- 3.1.6 Cardiovascular Diseases -- 3.1.7 Obesity-Induced Metabolic Disorders -- 3.2 Senomorphic Potential of Metformin -- 3.3 Senomorphic Potential of Rapamycin -- 3.4 Human Trials of Senotherapeutic Candidates -- 3.5 Future Opportunities for Senotherapeutic Research -- 3.5.1 Evaluating the Toxicity of Senotherapeutics -- 3.5.2 Defining and Classifying Ageing as a Disease -- 3.5.3 Performing More Studies About Treatment Regimen and Frequency -- 3.5.4 Combining Senotherapies with Other Anti-Ageing Treatments -- 3.5.5 Addressing the Heterogeneity of Senescent Cells -- 3.5.6 Validating if Senotherapies Slow Ageing -- 3.5.7 Preventing Senotherapies from Inhibiting the Therapeutic Benefits of Senescent Cells -- 3.5.8 Examining the Long-Term Therapeutic Benefits of Senotherapies -- 3.5.9 Conducting More Research About Senotherapeutics -- 3.6 Conclusion -- Further Reading -- References -- Chapter 4: Final Comments -- References -- Appendices -- Appendix 1: History of the Discovery and Development of Metformin to Treat Diabetes -- Appendix 2: Summary of Key Targets and Pathways Impacted by Metformin as Evidenced by Their Modulation in Cell Lines, C. elegans, Drosophila, and Rodents -- Appendix 3: Clinical Trials Using Metformin for Targeting Biological Ageing on https://www.clinicaltrials.gov as of February 18, 2024 -- Appendix 4: Characteristics of Studies Examining the Effects of Rapamycin and Its Derivatives on Healthy Individuals and Individuals with Age-Related Diseases -- Appendix 5: Clinical Trials of Senotherapeutics Registered on https://www.clinicaltrials.gov as of February 18, 2024 -- Glossary -- References.
• Titolo autorizzato: Senotherapy
• ISBN: 9789819736379; 9789819736362
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910872198803321
• Lo trovi qui: Univ. Federico II
• Serie: SpringerBriefs in Modern Perspectives on Disability Research Series