Vai al contenuto principale della pagina
Titolo: |
Oligonucleotide-based drugs and therapeutics : preclinical and clinical considerations for development / / edited by Nicolay Ferrari, Rosanne Seguin
![]() |
Pubblicazione: | John Wiley & Sons, Inc |
Disciplina: | 572.8/5 |
Soggetto topico: | Oligonucleotides - Therapeutic use |
Antisense nucleic acids - Therapeutic use | |
Persona (resp. second.): | FerrariNicolay <1969-> |
SeguinRosanne | |
Nota di contenuto: | Mechanisms of oligonucleotide actions -- The medicinal chemistry of antisense oligonucleotides -- Cellular pharmacology of antisense oligonucleotides -- Pharmacokinetics and pharmacodynamics of antisense oligonucleotides -- Tissue distribution, metabolism and clearance -- Hybridization-independent effects : principles and specific considerations for oligonucleotide drugs -- Hybridization-dependent effects : the prediction, evaluation and consequences of unintended target hybridization -- Class-related proinflammatory effects -- Exaggerated pharmacology -- Genotoxicity tests for novel oligonucleotide-based therapeutics -- Reproductive and developmental toxicity testing strategies for oligonucleotide-based therapeutics -- Specific considerations for preclinical development of inhaled oligonucleotides -- Lessons learned in oncology programs -- Inhaled antisense for treatment of respiratory disease -- Antisense oligonucleotides for treatment of neurology diseases -- Nucleic acids as adjuvants -- Splice-switching oligonucleotides -- CMC aspects for the clinical development of spiegelmers. |
Titolo autorizzato: | Oligonucleotide-based drugs and therapeutics ![]() |
ISBN: | 1-119-07030-9 |
1-119-07029-5 | |
1-119-07015-5 | |
Formato: | Materiale a stampa ![]() |
Livello bibliografico | Monografia |
Lingua di pubblicazione: | Inglese |
Record Nr.: | 9910830042603321 |
Lo trovi qui: | Univ. Federico II |
Opac: | Controlla la disponibilità qui |