Estrogen prevention for breast cancer [[electronic resource] /] / Zsuzsanna Suba, editor

• Pubblicazione: New York, : Nova Science Publishers, 2013
• Edizione: 1st ed.
• Descrizione fisica: 1 online resource (170 p.)
• Disciplina: 616.99/449
• Soggetto topico: Cancer - Hormone therapy; Estrogen; Breast - Cancer
• Altri autori: SubaZsuzsanna
• Note generali: "Nova biomedical."
• Nota di bibliografia: Includes bibliographical references and index.
• Nota di contenuto: Intro -- ESTROGEN PREVENTION FOR BREAST CANCER -- ESTROGEN PREVENTION FOR BREAST CANCER -- Library of Congress Cataloging-in-Publication Data -- Contents -- Preface -- Acknowledgements -- Chapter I: Discovery of Estrogen Deficiency as Common Cancer Risk Factor for Highly and Moderately Estrogen Dependent Organs -- Abstract -- Introduction -- Risk Factors for Cancers of Highly Hormone Related Organs -- Controversial Associations of Hormone Replacement Therapy and Cancer Risk -- Shortcomings of Studies on the Correlations between HRT Use and Cancer Risk -- Estrogen Deficiency and Cancer Risk in Postmenopausal Women -- Moderate Estrogen Deficiency and Cancer Risk in Premenopausal Women -- Conspicuous Differences between Cancer Epidemiology of Highly and Moderately Estrogen Dependent Organs -- Extraovarian Estrogen Synthesis -- Estrogen Deficiency in Men -- Conclusion -- References -- Chapter II: Interaction between Insulin and Estrogen in the Regulation of Cell Proliferation and Carcinogenesis -- Abstract -- Introduction -- Correlations between Insulin Resistance and Cancer Risk -- Historical Review of Associations between Estrogen and Cancer Development -- Molecular Mechanism of Interplay between the Actions of Estrogen and Insulin -- Clinical Correlations between Estrogen Deficiency, Insulin Resistance and Cancer Risk -- Conclusion -- References -- Chapter III: Dose Dependent Biphasic Effect of Alcohol on Estrogen Level and Cancer Risk -- Abstract -- Introduction -- Ambiguous Biphasic Metabolic and Hormonal Effects of Moderate and Excessive Alcohol Consumption -- Associations of Alcohol Consumption, Estrogen Level and Breast Cancer Risk -- Alcohol Consumption, Hormonal Changes and Risk for Oral Cancer -- Conclusion -- References -- Chapter IV: Estrogen Level May Be Protective for Breast Cancer in Obese Women -- Abstract -- Introduction. ; Grade and Distribution of Fat Deposition and Breast Cancer Risk -- Age-Related Role of Obesity in the Prediction of Breast Cancer Risk -- Effects of Reproductive Data and Menstrual Factors on Obesity-Associated Breast Cancer Risk -- Effects of Exogenous Hormone Treatment on Breast Cancer Risk -- Obesity Related Metabolic and Hormonal Disorders as Mediators of Breast Cancer Risk -- Counteraction between Obesity Associated Insulin Resistance and Protective Circulatory Estrogen Level -- Conclusion -- References -- Chapter V: Newly Recognized Player in Breast Cancer Risk: Light Deficiency -- Abstract -- Introduction -- Differences in Breast Cancer Incidence and Mortality between African-American and White American Women -- Excessive Cancer Risk of African-Americans and Dark Skinned Immigrants in Northern Geographic Regions -- Traditional Concept Concerning the Oncostatic Capacity of Melatonin Hormone -- Correlations between Excessive Melatonin Level, Other Endocrine Functions and Cancer Risk -- Correlations among Light Exposure, Melatonin Level and Breast Cancer Risk -- Conclusion -- References -- Chapter VI: Estrogen Prevention of Breast Cancer: A Critical Review -- Abstract -- Background: Randomized HRT WHI Trials -- Critique of the WHI HRT Trial Reporting -- Estrogen and the Rates of Invasive Breast Cancer -- Estrogen Benefit in Human Breast Cancer - Clinical Stage IV Breast Cancer -- Estrogen Benefit in Breast Cancer: Basic Research Data and Mechanism of Action -- Estrogen in Prevention of Breast Cancer? The Final 2000 - 2012 Reports -- Conclusion -- References -- Chapter VII: Failures and Controversies of the Antiestrogen Treatment of Breast Cancer -- Abstract -- Introduction -- Molecular Mechanisms of Estrogen Action -- Estrogen Receptors and Their Actions. ; Interplay between Alpha and Beta Estrogen Receptor Isoforms in the Regulation of Cell Proliferation and of Apoptotic Cell Death -- Cross Talk between Receptor Signals of Estrogen and Growth Factors -- Estrogen Receptors and Human Cancers -- Estrogen Synthesis in Tumors -- Antiestrogen and Estrogen in Cancer Therapy -- Conclusion -- References -- Chapter VIII: Evolution of Estrogen Action in Breast Cancer: From Culprit to Killer -- Abstract -- Introduction -- Evolution of Fashions in Breast Cancer Treatment and Prevention -- Selective ER Modulation: Translation from the Laboratory to Clinical Practice -- A Roadmap to Use SERMS to Prevent Multiple Diseases in Women -- Raloxifene in Clinical Practice -- Summary of SERMs -- The Evolution of Acquired Resistance to Antihormonal Therapies -- Molecular Mechanisms of the Apoptotic Action of Estrogens -- Clinical Significance of Estrogen Induced Apoptosis -- Conclusion -- Acknowledgments -- References -- Index.
• Titolo autorizzato: Estrogen prevention for breast cancer
• ISBN: 1-62417-393-4
• Formato: Materiale a stampa
• Livello bibliografico: Monografia
• Lingua di pubblicazione: Inglese
• Record Nr.: 9910816826603321
• Lo trovi qui: Univ. Federico II
• Serie: Cancer etiology, diagnosis, and treatments.